HUMAN:MK03

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPK3 (synonyms: ERK1, PRKM3)
Protein Name(s)	Mitogen-activated protein kinase 3 MAP kinase 3 MAPK 3 ERT2 Extracellular signal-regulated kinase 1 ERK-1 Insulin-stimulated MAP2 kinase MAP kinase isoform p44 p44-MAPK Microtubule-associated protein 2 kinase p44-ERK1
External Links
UniProt	P27361
EMBL	X60188 AY033607 DQ399291 EU332853 AC012645 CH471238 CH471238 BC013992 M84490 Z11696
CCDS	CCDS10672.1 CCDS42148.1 CCDS42149.1
PIR	A48082
RefSeq	NP_001035145.1 NP_001103361.1 NP_002737.2
UniGene	Hs.861
PDB	2ZOQ 4QTB
PDBsum	2ZOQ 4QTB
ProteinModelPortal	P27361
SMR	P27361
BioGrid	111581
DIP	DIP-30985N
IntAct	P27361
MINT	MINT-99599
STRING	9606.ENSP00000263025
BindingDB	P27361
ChEMBL	CHEMBL1907606
DrugBank	DB01169 DB00605
GuidetoPHARMACOLOGY	1494
PhosphoSite	P27361
DMDM	232066
MaxQB	P27361
PaxDb	P27361
PRIDE	P27361
DNASU	5595
Ensembl	ENST00000263025 ENST00000322266 ENST00000395199 ENST00000395202
GeneID	5595
KEGG	hsa:5595
UCSC	uc002dwr.3 uc002dwt.3 uc002dwv.4
CTD	5595
GeneCards	GC16M030125
HGNC	HGNC:6877
HPA	CAB002683 HPA003995 HPA005700
MIM	601795
neXtProt	NX_P27361
PharmGKB	PA30622
eggNOG	COG0515
GeneTree	ENSGT00550000074298
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P27361
KO	K04371
OMA	QETAPFQ
OrthoDB	EOG7M3J0K
PhylomeDB	P27361
TreeFam	TF105097
BRENDA	2.7.11.24
Reactome	REACT_1100 REACT_111133 REACT_111184 REACT_115831 REACT_120966 REACT_12436 REACT_12599 REACT_1391 REACT_160086 REACT_163701 REACT_169168 REACT_169325 REACT_169436 REACT_18334 REACT_200780 REACT_21326 REACT_21384 REACT_22272 REACT_2232 REACT_25195 REACT_508 REACT_9470
SignaLink	P27361
EvolutionaryTrace	P27361
GeneWiki	MAPK3
GenomeRNAi	5595
NextBio	21714
PRO	PR:P27361
Proteomes	UP000005640
Bgee	P27361
CleanEx	HS_MAPK3
ExpressionAtlas	P27361
Genevestigator	P27361
GO	GO:0005901 GO:0005856 GO:0005829 GO:0005769 GO:0070062 GO:0005925 GO:0005794 GO:0005770 GO:0015630 GO:0005739 GO:0005654 GO:0005634 GO:0031143 GO:0005524 GO:0004707 GO:0019902 GO:0000187 GO:0000186 GO:0006915 GO:0007411 GO:0007596 GO:0030509 GO:0051216 GO:0072584 GO:0007049 GO:0071260 GO:0019221 GO:0006975 GO:0007173 GO:0038095 GO:0038096 GO:0008543 GO:0010467 GO:0045087 GO:0008286 GO:0070498 GO:0060397 GO:0031663 GO:0000165 GO:0002755 GO:0002756 GO:2000657 GO:0048011 GO:0009887 GO:0038083 GO:0016310 GO:0030168 GO:0070374 GO:0035066 GO:0033129 GO:0001934 GO:0045944 GO:0006468 GO:0007265 GO:0051493 GO:2000641 GO:0090170 GO:0051090 GO:0032872 GO:0070849 GO:0043330 GO:0019233 GO:0007264 GO:0051403 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0006360 GO:0006361 GO:0035666 GO:0016032
InterPro	IPR011009 IPR003527 IPR008349 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01770
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070849	response to epidermal growth factor stimulus	PMID:21968647^[1]	ECO:0000314			P		Overexpression of PAQR10 or PAQR11 also significantly enhanced and prolonged the phosphorylation of ERK upon EGF treatment (Figure 1D).	complete CACAO 2194
	GO:0051247	positive regulation of protein metabolic process	PMID:22027397^[2]	ECO:0000315			P		Fig. 5C	complete CACAO 2989
	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[2]	ECO:0000315			P		Fig. 5D	complete CACAO 2990
involved_in	GO:0071276	cellular response to cadmium ion	PMID:26514923^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:26514923^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:11096076^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	PMID:11096076^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:24136195^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24136195^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P0DMM9) has_regulation_target:(UniProtKB:P50225)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21708	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21708	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P21708	C		Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21531765^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032212) part_of:(GO:0051973)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:21531765^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:21531765^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0031281	positive regulation of cyclase activity	PMID:22027397^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	PMID:21968647^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005635	nuclear envelope	PMID:20455999^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	PMID:20018936^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:19664780^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20018936^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035066	positive regulation of histone acetylation	PMID:20018936^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	PMID:20018936^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030509	BMP signaling pathway	PMID:19664780^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:19664780^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:20018936^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	PMID:18794356^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:8388392^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	PMID:19494114^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	PMID:15950189^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:17560175^[15]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P23396)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:7687743^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:8388392^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7687743^[16]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22307056^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27361	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16627622^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27361	F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	F		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
involved_in	GO:0019369	arachidonic acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21708 ensembl:ENSRNOP00000070784	P		Seeded From UniProt	complete
involved_in	GO:2000657	negative regulation of apolipoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:1905050	positive regulation of metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:1904417	positive regulation of xenophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0061308	cardiac neural crest cell development involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0042473	outer ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0030641	regulation of cellular pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0010759	positive regulation of macrophage chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F		Seeded From UniProt	complete
involved_in	GO:0002741	positive regulation of cytokine secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63844 ensembl:ENSMUSP00000051619	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008349	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008349 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008349	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090170	regulation of Golgi inheritance	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051493	regulation of cytoskeleton organization	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19565474^[20] Reactome:R-HSA-6802933 Reactome:R-HSA-6802932 Reactome:R-HSA-6802926 Reactome:R-HSA-6802925 Reactome:R-HSA-6802922 Reactome:R-HSA-6802921 Reactome:R-HSA-6802919 Reactome:R-HSA-6802918 Reactome:R-HSA-6802914 Reactome:R-HSA-6802912 Reactome:R-HSA-6802911 Reactome:R-HSA-6802910 Reactome:R-HSA-5675376 Reactome:R-HSA-5675206 Reactome:R-HSA-5675198 Reactome:R-HSA-5675194 Reactome:R-HSA-5674496 Reactome:R-HSA-5674387 Reactome:R-HSA-5674385 Reactome:R-HSA-5674373 Reactome:R-HSA-5674366 Reactome:R-HSA-5674132 Reactome:R-HSA-5674130 Reactome:R-HSA-5672980 Reactome:R-HSA-5672978 Reactome:R-HSA-5672973 Reactome:R-HSA-5672972 Reactome:R-HSA-5654566 Reactome:R-HSA-5654565 Reactome:R-HSA-5654562 Reactome:R-HSA-5654560 Reactome:R-HSA-418200 Reactome:R-HSA-418176 Reactome:R-HSA-418170 Reactome:R-HSA-418163 Reactome:R-HSA-418158 Reactome:R-HSA-3371531 Reactome:R-HSA-2029469 Reactome:R-HSA-1678841 Reactome:R-HSA-1169406 Reactome:R-HSA-1168459 Reactome:R-HSA-109863 Reactome:R-HSA-109860 Reactome:R-HSA-109857 Reactome:R-HSA-109823 Reactome:R-HSA-109822 Reactome:R-HSA-9627089 Reactome:R-HSA-9626832 Reactome:R-HSA-6811472 Reactome:R-HSA-6811454 Reactome:R-HSA-6803234 Reactome:R-HSA-6803233 Reactome:R-HSA-6803230 Reactome:R-HSA-6803227 Reactome:R-HSA-6802943 Reactome:R-HSA-6802942 Reactome:R-HSA-6802935 Reactome:R-HSA-6802934	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19565474^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9032751 Reactome:R-HSA-73722 Reactome:R-HSA-5675373 Reactome:R-HSA-5674387 Reactome:R-HSA-450325 Reactome:R-HSA-3857329 Reactome:R-HSA-3132737 Reactome:R-HSA-203797 Reactome:R-HSA-199959 Reactome:R-HSA-198756 Reactome:R-HSA-198746	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-112409	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	Reactome:R-HSA-169893	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	Reactome:R-HSA-450341	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-6811558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654743 Reactome:R-HSA-5654741 Reactome:R-HSA-5654738 Reactome:R-HSA-5654736	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006361	transcription initiation from RNA polymerase I promoter	Reactome:R-HSA-73728	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Jin, T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res. 22 661-76 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page
↑ ^3.0 ^3.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^4.0 ^4.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wang, B et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30 536-45 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Yang, X et al. (2009) Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J. Thorac. Cardiovasc. Surg. 138 1008-15 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ Vomastek, T et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol. Cell. Biol. 28 6954-66 PubMed GONUTS page
↑ ^12.0 ^12.1 Zheng, CF & Guan, KL (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 11435-9 PubMed GONUTS page
↑ Sacco, F et al. (2009) Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J. Biol. Chem. 284 22048-58 PubMed GONUTS page
↑ Kim, HD et al. (2005) Erk phosphorylates threonine 42 residue of ribosomal protein S3. Biochem. Biophys. Res. Commun. 333 110-5 PubMed GONUTS page
↑ Yadavilli, S et al. (2007) Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. DNA Repair (Amst.) 6 1453-62 PubMed GONUTS page
↑ ^16.0 ^16.1 Charest, DL et al. (1993) Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol. Cell. Biol. 13 4679-90 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Kim, MO et al. (2012) ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat. Struct. Mol. Biol. 19 283-90 PubMed GONUTS page
↑ Kauppinen, TM et al. (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. U.S.A. 103 7136-41 PubMed GONUTS page
↑ ^20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 ^20.12 ^20.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[PMID:21968647-1] 1.0 ^1.1 Jin, T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res. 22 661-76 PubMed GONUTS page

[PMID:22027397-2] 2.0 ^2.1 ^2.2 Mamik, MK et al. (2011) HIV-1 and IL-1β regulate astrocytic CD38 through mitogen-activated protein kinases and nuclear factor-κB signaling mechanisms. J Neuroinflammation 8 145 PubMed GONUTS page

[PMID:26514923-3] 3.0 ^3.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page

[PMID:11096076-4] 4.0 ^4.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page

[PMID:24136195-5] 5.0 ^5.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page

[PMID:21531765-6] 6.0 ^6.1 ^6.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:20455999-7] Kwon, H et al. (2011) A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2. J. Cell. Mol. Med. 15 888-908 PubMed GONUTS page

[PMID:20018936-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Wang, B et al. (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30 536-45 PubMed GONUTS page

[PMID:19664780-9] 9.0 ^9.1 ^9.2 Yang, X et al. (2009) Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J. Thorac. Cardiovasc. Surg. 138 1008-15 PubMed GONUTS page

[PMID:19593445-10] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:18794356-11] Vomastek, T et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol. Cell. Biol. 28 6954-66 PubMed GONUTS page

[PMID:8388392-12] 12.0 ^12.1 Zheng, CF & Guan, KL (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268 11435-9 PubMed GONUTS page

[PMID:19494114-13] Sacco, F et al. (2009) Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J. Biol. Chem. 284 22048-58 PubMed GONUTS page

[PMID:15950189-14] Kim, HD et al. (2005) Erk phosphorylates threonine 42 residue of ribosomal protein S3. Biochem. Biophys. Res. Commun. 333 110-5 PubMed GONUTS page

[PMID:17560175-15] Yadavilli, S et al. (2007) Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress. DNA Repair (Amst.) 6 1453-62 PubMed GONUTS page

[PMID:7687743-16] 16.0 ^16.1 Charest, DL et al. (1993) Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. Mol. Cell. Biol. 13 4679-90 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 ^17.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22307056-18] Kim, MO et al. (2012) ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4. Nat. Struct. Mol. Biol. 19 283-90 PubMed GONUTS page

[PMID:16627622-19] Kauppinen, TM et al. (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. U.S.A. 103 7136-41 PubMed GONUTS page

[PMID:19565474-20] 20.00 ^20.01 ^20.02 ^20.03 ^20.04 ^20.05 ^20.06 ^20.07 ^20.08 ^20.09 ^20.10 ^20.11 ^20.12 ^20.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

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