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PMID:20018936

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Citation

Wang, B, Chen, J, Santiago, FS, Janes, M, Kavurma, MM, Chong, BH, Pimanda, JE and Khachigian, LM (2010) Phosphorylation and acetylation of histone H3 and autoregulation by early growth response 1 mediate interleukin 1beta induction of early growth response 1 transcription. Arterioscler. Thromb. Vasc. Biol. 30:536-45

Abstract

The transcription factor early growth response (EGR)-1 has been implicated as a key vascular phenotypic switch through its control of inducible transcription. EGR-1 autoregulation, and histone modification in the EGR-1 promoter, represent key mechanisms in EGR-1 control, but have not been explored.

Links

PubMed Online version:10.1161/ATVBAHA.109.193821

Keywords

Acetylation; Animals; Base Sequence; Cells, Cultured; Early Growth Response Protein 1/genetics; Early Growth Response Protein 1/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Histones/metabolism; Homeostasis/physiology; Humans; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Models, Animal; Molecular Sequence Data; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/metabolism; Phosphorylation; Promoter Regions, Genetic/physiology; Rats; Signal Transduction/physiology; Transcription, Genetic/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:KS6A5

involved_in

GO:0016572: histone phosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A5

involved_in

GO:0033129: positive regulation of histone phosphorylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A5

involved_in

GO:0070498: interleukin-1-mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A5

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A5

involved_in

GO:0035066: positive regulation of histone acetylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A4

involved_in

GO:0016572: histone phosphorylation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A4

involved_in

GO:0033129: positive regulation of histone phosphorylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A4

involved_in

GO:0070498: interleukin-1-mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A4

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KS6A4

involved_in

GO:0035066: positive regulation of histone acetylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:EGR1

enables

GO:0000981: DNA-binding transcription factor activity, RNA polymerase II-specific

ECO:0000314: direct assay evidence used in manual assertion

F

  • occurs_at:(SO:0001952)

Seeded From UniProt

complete

HUMAN:EGR1

enables

GO:0035035: histone acetyltransferase binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q09472

F

Seeded From UniProt

complete

HUMAN:EGR1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:EGR1

involved_in

GO:0070498: interleukin-1-mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:EGR1

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:ELK1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:EP300

enables

GO:0061629: RNA polymerase II-specific DNA-binding transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P18146

F

Seeded From UniProt

complete

HUMAN:MK03

involved_in

GO:0000165: MAPK cascade

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK03

involved_in

GO:0035066: positive regulation of histone acetylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK03

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK03

involved_in

GO:0033129: positive regulation of histone phosphorylation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MK03

involved_in

GO:0070498: interleukin-1-mediated signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL1B

involved_in

GO:0033129: positive regulation of histone phosphorylation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IL1B

involved_in

GO:0035066: positive regulation of histone acetylation

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

HUMAN:EP300

enables

GO:0001102: RNA polymerase II activating transcription factor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P18146

F

Seeded From UniProt

complete

MOUSE:EGR1

enables

GO:0000981: DNA-binding transcription factor activity, RNA polymerase II-specific

ECO:0000314: direct assay evidence used in manual assertion

F

occurs_at:(SO:0001952)

Seeded From UniProt

complete

MOUSE:EGR1

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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