HUMAN:HDAC1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HDAC1 (synonyms: RPD3L1)
Protein Name(s)	Histone deacetylase 1 HD1
External Links
UniProt	Q13547
EMBL	U50079 D50405 BC000301
CCDS	CCDS360.1
RefSeq	NP_004955.2
UniGene	Hs.88556
PDB	1TYI 4BKX
PDBsum	1TYI 4BKX
ProteinModelPortal	Q13547
SMR	Q13547
BioGrid	109315
DIP	DIP-24184N
IntAct	Q13547
MINT	MINT-90475
STRING	9606.ENSP00000362649
BindingDB	Q13547
ChEMBL	CHEMBL2093865
DrugBank	DB02546
GuidetoPHARMACOLOGY	2658
PhosphoSite	Q13547
DMDM	2498443
MaxQB	Q13547
PaxDb	Q13547
PeptideAtlas	Q13547
PRIDE	Q13547
DNASU	3065
Ensembl	ENST00000373548
GeneID	3065
KEGG	hsa:3065
UCSC	uc001bvb.1
CTD	3065
GeneCards	GC01P032757
HGNC	HGNC:4852
HPA	CAB005017 HPA029693
MIM	601241
neXtProt	NX_Q13547
PharmGKB	PA29226
eggNOG	COG0123
HOGENOM	HOG000225180
HOVERGEN	HBG057112
InParanoid	Q13547
KO	K06067
OMA	LTQGTKR
OrthoDB	EOG7DNNTW
PhylomeDB	Q13547
TreeFam	TF106171
Reactome	REACT_111214 REACT_118780 REACT_120734 REACT_121111 REACT_13695 REACT_160243 REACT_160254 REACT_200731 REACT_200753 REACT_200856 REACT_228106 REACT_228222 REACT_24970 REACT_953
SABIO-RK	Q13547
ChiTaRS	HDAC1
GeneWiki	HDAC1
GenomeRNAi	3065
NextBio	12125
PRO	PR:Q13547
Proteomes	UP000005640
Bgee	Q13547
CleanEx	HS_HDAC1
ExpressionAtlas	Q13547
Genevestigator	Q13547
GO	GO:0000785 GO:0005737 GO:0005829 GO:0000118 GO:0000790 GO:0005654 GO:0005634 GO:0016581 GO:0043234 GO:0016580 GO:0033613 GO:0001047 GO:0019213 GO:0019899 GO:0004407 GO:0042826 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0033558 GO:0070491 GO:0001103 GO:0001106 GO:0003700 GO:0008134 GO:0044212 GO:0000976 GO:0043044 GO:0007596 GO:0016568 GO:0006338 GO:0032922 GO:0042733 GO:0009913 GO:0061029 GO:0061198 GO:0010467 GO:0060789 GO:0016575 GO:0070932 GO:0070933 GO:0000278 GO:0043922 GO:0060766 GO:0043066 GO:0045786 GO:0000122 GO:0045892 GO:0048011 GO:0007219 GO:0042475 GO:0008284 GO:0010870 GO:0045944 GO:0045893 GO:0006476 GO:0006367 GO:0006351 GO:0007179 GO:0016032
Gene3D	3.40.800.20
InterPro	IPR000286 IPR003084 IPR023801
PANTHER	PTHR10625
Pfam	PF00850
PIRSF	PIRSF037913
PRINTS	PR01270 PR01271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0016581	NuRD complex	PMID:22926524^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900221	regulation of amyloid-beta clearance	PMID:19057576^[2]	ECO:0000305	curator inference used in manual assertion	GO:0000979,GO:0006357,GO:0052548	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:19057576^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000097,UniProtKB:P05067:PRO_0000000098	P	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)\|has_input(ENSEMBL:ENSG00000196549) occurs_in:(CL:0002618)	Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	PMID:19057576^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(ENSEMBL:ENSG00000196549) occurs_in:(CL:0000540)\|has_input(ENSEMBL:ENSG00000196549) occurs_in:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:0052548	regulation of endopeptidase activity	PMID:19057576^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P08473)	Seeded From UniProt	complete
	GO:0010629	negative regulation of gene expression	PMID:16581785^[3]	ECO:0000315			P		Figure 3: Acts as a repressor of INF-beta gene expression	complete CACAO 8834
part_of	GO:0000790	nuclear chromatin	PMID:23770133^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000206075) coincident_with:(SO:0000170)	Seeded From UniProt	complete
involved_in	GO:0006346	methylation-dependent chromatin silencing	PMID:23770133^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9UBB5	P	regulates_transcription_of:(ENSEMBL:ENSG00000206075)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:28046085^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:28046085^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N108	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:28046085^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8N344	F	has_direct_input:(InterPro:IPR000949)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:23629966^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001046	core promoter sequence-specific DNA binding	PMID:23629966^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:23629966^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:23629966^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:23629966^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:18936100^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04426,UniProtKB:Q9NYF0	P	occurs_in:(GO:0005634)	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18936100^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P04426,UniProtKB:Q9NYF0	P	occurs_in:(GO:0005634)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18936100^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJU2	F	occurs_in:(GO:0005634)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18936100^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	PMID:17785205^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q04206	F		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:16581785^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:16731528^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16731528^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P07101)	Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	PMID:16731528^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23246	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043044	ATP-dependent chromatin remodeling	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0031492	nucleosomal DNA binding	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:22720776^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:16217013^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:12590135^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:12590135^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	PMID:15919722^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16762839^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16762839^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:12590135^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UKV0	F		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:17827154^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	PMID:17827154^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:18316616^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0010832	negative regulation of myotube differentiation	PMID:10983972^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:18347167^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18850004^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08047	F		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:17827154^[15]	ECO:0000305	curator inference used in manual assertion	GO:0004407	P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:16762839^[14]	ECO:0000305	curator inference used in manual assertion	GO:0004407	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:22926524^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18347167^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:16762839^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:15919722^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:22926524^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96BF6	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22926524^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18850004^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:18854353^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18247378^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P36952)	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18974119^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P49767)	Seeded From UniProt	complete
involved_in	GO:0043922	negative regulation by host of viral transcription	PMID:16540471^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:20590529^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14814	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:20590529^[24]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02078	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:19182791^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:17172643^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11641274^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NWT6	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11062478^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02880	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11062478^[28]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11136718^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02880	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11136718^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	F		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:19644445^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:19182791^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16569215^[31]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01101	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:18974119^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99801	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15509593^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35680-1	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:17172643^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18326024^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10846170^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:17996965^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:19182791^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:18974119^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q99801	F	has_input:(UniProtKB:P49767)	Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O09106	F		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 MGI:MGI:1343091 PANTHER:PTN002578320 PomBase:SPAC3G9.07c SGD:S000005274 SGD:S000006272 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 RGD:1309799 RGD:619976 RGD:619977 SGD:S000005274 TAIR:locus:2098115 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 PANTHER:PTN000066122 PomBase:SPBC36.05c SGD:S000005274 UniProtKB:Q13547 UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002578320 PomBase:SPBC36.05c SGD:S000005274 SGD:S000006272 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 FB:FBgn0025825 MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c RGD:1309799 SGD:S000003162 SGD:S000005274 TAIR:locus:2162017 UniProtKB:G5EB64 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q7K6A1 UniProtKB:Q92769 WB:WBGene00001834 dictyBase:DDB_G0270338	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:21873635^[36]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 MGI:MGI:108086 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c SGD:S000003162 SGD:S000005274 SGD:S000006272 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:17150957^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
enables	GO:0035851	Krueppel-associated box domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
involved_in	GO:0007492	endoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	P		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09106 ensembl:ENSMUSP00000099657	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	P		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
acts_upstream_of	GO:0043066	negative regulation of apoptotic process	PMID:10777477^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:12711221^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12711221^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12711221^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:12711221^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:12711221^[39]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904837	beta-catenin-TCF complex assembly	Reactome:R-HSA-201722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045652	regulation of megakaryocyte differentiation	Reactome:R-HSA-8936459	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-3299567 Reactome:R-HSA-996727 Reactome:R-HSA-9023461 Reactome:R-HSA-9009065 Reactome:R-HSA-9005995 Reactome:R-HSA-8943780 Reactome:R-HSA-8937118 Reactome:R-HSA-8937113 Reactome:R-HSA-8937022 Reactome:R-HSA-8936989 Reactome:R-HSA-8936608 Reactome:R-HSA-8936599 Reactome:R-HSA-8936584 Reactome:R-HSA-8935732 Reactome:R-HSA-8935730 Reactome:R-HSA-6805650 Reactome:R-HSA-4615889 Reactome:R-HSA-3769447 Reactome:R-HSA-3361751 Reactome:R-HSA-3299569 Reactome:R-HSA-2220982 Reactome:R-HSA-2186607 Reactome:R-HSA-1227671 Reactome:R-HSA-1227670	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	Reactome:R-HSA-2173795	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Belyaev, ND et al. (2009) Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 10 94-100 PubMed GONUTS page
↑ ^3.0 ^3.1 Nusinzon, I & Horvath, CM (2006) Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol. Cell. Biol. 26 3106-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Yuan, K et al. (2013) Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology 145 853-64.e9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Derwish, R et al. (2017) Differential HDAC1 and 2 Recruitment by Members of the MIER Family. PLoS ONE 12 e0169338 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Gao, X et al. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J. Biol. Chem. 283 35679-88 PubMed GONUTS page
↑ Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Zhong, N et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem. 281 20940-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page
↑ Todd, MA & Picketts, DJ (2012) PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J. Proteome Res. 11 4326-37 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Petrie, K et al. (2003) The histone deacetylase 9 gene encodes multiple protein isoforms. J. Biol. Chem. 278 16059-72 PubMed GONUTS page
↑ ^13.0 ^13.1 Hong, CY et al. (2005) Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol. Endocrinol. 19 2245-57 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Qiu, Y et al. (2006) HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol. Cell 22 669-79 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page
↑ Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page
↑ Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page
↑ ^18.0 ^18.1 Weichert, W et al. (2008) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res. 14 1669-77 PubMed GONUTS page
↑ ^19.0 ^19.1 Mottet, D et al. (2009) HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene 28 243-56 PubMed GONUTS page
↑ Jahnke, P et al. (2008) The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications. Nucleic Acids Res. 36 6450-8 PubMed GONUTS page
↑ Yamaguchi, H et al. (2008) Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol. Carcinog. 47 739-43 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Zhang, H et al. (2008) Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer. Cancer Res. 68 8770-8 PubMed GONUTS page
↑ Imai, K & Okamoto, T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J. Biol. Chem. 281 12495-505 PubMed GONUTS page
↑ ^24.0 ^24.1 Aude-Garcia, C et al. (2010) Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression. Biochem. J. 430 237-44 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Oh, YM et al. (2009) Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat. Cell Biol. 11 295-302 PubMed GONUTS page
↑ ^26.0 ^26.1 Shimazu, T et al. (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J. Biol. Chem. 282 4470-8 PubMed GONUTS page
↑ Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page
↑ ^28.0 ^28.1 Tsai, SC et al. (2000) Histone deacetylase interacts directly with DNA topoisomerase II. Nat. Genet. 26 349-53 PubMed GONUTS page
↑ ^29.0 ^29.1 Johnson, CA et al. (2001) Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. J. Biol. Chem. 276 4539-42 PubMed GONUTS page
↑ Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page
↑ Liu, WD et al. (2006) INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem. J. 397 169-77 PubMed GONUTS page
↑ Barbacci, E et al. (2004) HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment. Hum. Mol. Genet. 13 3139-49 PubMed GONUTS page
↑ Ishii, S et al. (2008) Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment. Proc. Natl. Acad. Sci. U.S.A. 105 4179-84 PubMed GONUTS page
↑ Cai, RL et al. (2000) HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. J. Biol. Chem. 275 27909-16 PubMed GONUTS page
↑ Wang, J et al. (2008) The orphan nuclear receptor Rev-erbbeta recruits Tip60 and HDAC1 to regulate apolipoprotein CIII promoter. Biochim. Biophys. Acta 1783 224-36 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 ^36.3 ^36.4 ^36.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Shen, Y et al. (2007) Functional architecture of atrophins. J. Biol. Chem. 282 5037-44 PubMed GONUTS page
↑ Juan, LJ et al. (2000) Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem. 275 20436-43 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

[PMID:22926524-1] 1.0 ^1.1 ^1.2 ^1.3 Xuan, C et al. (2013) RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene 32 3711-21 PubMed GONUTS page

[PMID:19057576-2] 2.0 ^2.1 ^2.2 ^2.3 Belyaev, ND et al. (2009) Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 10 94-100 PubMed GONUTS page

[PMID:16581785-3] 3.0 ^3.1 Nusinzon, I & Horvath, CM (2006) Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol. Cell. Biol. 26 3106-13 PubMed GONUTS page

[PMID:23770133-4] 4.0 ^4.1 Yuan, K et al. (2013) Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice. Gastroenterology 145 853-64.e9 PubMed GONUTS page

[PMID:28046085-5] 5.0 ^5.1 ^5.2 Derwish, R et al. (2017) Differential HDAC1 and 2 Recruitment by Members of the MIER Family. PLoS ONE 12 e0169338 PubMed GONUTS page

[PMID:23629966-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page

[PMID:18936100-7] 7.0 ^7.1 ^7.2 ^7.3 Gao, X et al. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. J. Biol. Chem. 283 35679-88 PubMed GONUTS page

[PMID:17785205-8] Wang, J et al. (2007) LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. Cancer Cell 12 239-51 PubMed GONUTS page

[PMID:16731528-9] 9.0 ^9.1 ^9.2 Zhong, N et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J. Biol. Chem. 281 20940-8 PubMed GONUTS page

[PMID:16217013-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 Mahajan, MC et al. (2005) Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc. Natl. Acad. Sci. U.S.A. 102 15012-7 PubMed GONUTS page

[PMID:22720776-11] Todd, MA & Picketts, DJ (2012) PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J. Proteome Res. 11 4326-37 PubMed GONUTS page

[PMID:12590135-12] 12.0 ^12.1 ^12.2 Petrie, K et al. (2003) The histone deacetylase 9 gene encodes multiple protein isoforms. J. Biol. Chem. 278 16059-72 PubMed GONUTS page

[PMID:15919722-13] 13.0 ^13.1 Hong, CY et al. (2005) Modulation of the expression and transactivation of androgen receptor by the basic helix-loop-helix transcription factor Pod-1 through recruitment of histone deacetylase 1. Mol. Endocrinol. 19 2245-57 PubMed GONUTS page

[PMID:16762839-14] 14.0 ^14.1 ^14.2 ^14.3 Qiu, Y et al. (2006) HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol. Cell 22 669-79 PubMed GONUTS page

[PMID:17827154-15] 15.0 ^15.1 ^15.2 Sun, JM et al. (2007) Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J. Biol. Chem. 282 33227-36 PubMed GONUTS page

[PMID:18316616-16] Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page

[PMID:10983972-17] Lu, J et al. (2000) Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol. Cell 6 233-44 PubMed GONUTS page

[PMID:18347167-18] 18.0 ^18.1 Weichert, W et al. (2008) Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res. 14 1669-77 PubMed GONUTS page

[PMID:18850004-19] 19.0 ^19.1 Mottet, D et al. (2009) HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene 28 243-56 PubMed GONUTS page

[PMID:18854353-20] Jahnke, P et al. (2008) The Cohesin loading factor NIPBL recruits histone deacetylases to mediate local chromatin modifications. Nucleic Acids Res. 36 6450-8 PubMed GONUTS page

[PMID:18247378-21] Yamaguchi, H et al. (2008) Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol. Carcinog. 47 739-43 PubMed GONUTS page

[PMID:18974119-22] 22.0 ^22.1 ^22.2 Zhang, H et al. (2008) Loss of NKX3.1 favors vascular endothelial growth factor-C expression in prostate cancer. Cancer Res. 68 8770-8 PubMed GONUTS page

[PMID:16540471-23] Imai, K & Okamoto, T (2006) Transcriptional repression of human immunodeficiency virus type 1 by AP-4. J. Biol. Chem. 281 12495-505 PubMed GONUTS page

[PMID:20590529-24] 24.0 ^24.1 Aude-Garcia, C et al. (2010) Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression. Biochem. J. 430 237-44 PubMed GONUTS page

[PMID:19182791-25] 25.0 ^25.1 ^25.2 Oh, YM et al. (2009) Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nat. Cell Biol. 11 295-302 PubMed GONUTS page

[PMID:17172643-26] 26.0 ^26.1 Shimazu, T et al. (2007) Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J. Biol. Chem. 282 4470-8 PubMed GONUTS page

[PMID:11641274-27] Mahon, PC et al. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15 2675-86 PubMed GONUTS page

[PMID:11062478-28] 28.0 ^28.1 Tsai, SC et al. (2000) Histone deacetylase interacts directly with DNA topoisomerase II. Nat. Genet. 26 349-53 PubMed GONUTS page

[PMID:11136718-29] 29.0 ^29.1 Johnson, CA et al. (2001) Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis. J. Biol. Chem. 276 4539-42 PubMed GONUTS page

[PMID:19644445-30] Li, R et al. (2009) ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 28 2763-76 PubMed GONUTS page

[PMID:16569215-31] Liu, WD et al. (2006) INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem. J. 397 169-77 PubMed GONUTS page

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