DROME:TIM

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	tim
Protein Name(s)	Protein timeless
External Links
UniProt	P49021
EMBL	U37018 AF032401 AF032400 AE014134 AE014134 AE014134 AE014134 AE014134 AE014134 AE014134 AE014134 AE014134 Y09930 Y09931 Y09932 Y09933 Y09934 Y09935 AY058278 BT001424 BT024951 BT099999 AF038501
PIR	A57655
RefSeq	NP_001014463.2 NP_001033872.2 NP_001137780.2 NP_001137781.2 NP_001188686.2 NP_722912.3 NP_722913.3 NP_722914.3
UniGene	Dm.2663
BioGrid	59781
DIP	DIP-29425N
MINT	MINT-344208
EnsemblMetazoa	FBtr0333253 FBtr0333254 FBtr0333255 FBtr0333258 FBtr0333259
GeneID	33571
KEGG	dme:Dmel_CG3234
UCSC	CG3234-RA
CTD	107698
FlyBase	FBgn0014396
eggNOG	NOG257888
GeneTree	ENSGT00390000015124
InParanoid	P49021
KO	K12074
OMA	LHIPETH
OrthoDB	EOG7SXW2F
GenomeRNAi	33571
NextBio	784249
Proteomes	UP000000803
Bgee	P49021
ExpressionAtlas	P49021
GO	GO:0005737 GO:0005634 GO:0048471 GO:0043234 GO:0046982 GO:0008134 GO:0071482 GO:0048512 GO:0007623 GO:0060086 GO:0007620 GO:0008062 GO:0009649 GO:0045475 GO:0007617 GO:0046957 GO:0000122 GO:2000678 GO:0009648 GO:0006606 GO:0042749 GO:0045187 GO:0042306 GO:0007622 GO:0030431
InterPro	IPR006906
Pfam	PF04821

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0050764	regulation of phagocytosis	PMID:22253593^[1]	ECO:0000315			P	Figure 5: Tim mutant flies do not express increased phagocytosis during circadian cycles when exposed to S. aureus	complete CACAO 6721
	GO:0050766	positive regulation of phagocytosis	PMID:22253593^[1]	ECO:0000315			P	Figure 5: Tim mutant flies do not express increased phagocytosis during circadian cycles when exposed to S. aureus	complete CACAO 7035
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:22253593^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050764	regulation of phagocytosis	PMID:22253593^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048478	replication fork protection	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 PomBase:SPBC216.06c SGD:S000005217	P	Seeded From UniProt	complete
involved_in	GO:0043111	replication fork arrest	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 PomBase:SPBC216.06c SGD:S000005217	P	Seeded From UniProt	complete
part_of	GO:0031298	replication fork protection complex	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 SGD:S000005217	C	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014396 FB:FBgn0038118 PANTHER:PTN000533816	P	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 SGD:S000005217	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014396 MGI:MGI:1321393 PANTHER:PTN000533813 PomBase:SPBC216.06c RGD:620939 SGD:S000005217 UniProtKB:Q9UNS1 WB:WBGene00006571	C	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 PomBase:SPBC216.06c	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 PomBase:SPBC216.06c UniProtKB:Q9UNS1	C	Seeded From UniProt	complete
involved_in	GO:0000076	DNA replication checkpoint	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000533813 SGD:S000005217	P	Seeded From UniProt	complete
involved_in	GO:0003053	circadian regulation of heart rate	PMID:25766238^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:25165772^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:25148297^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060086	circadian temperature homeostasis	PMID:22981774^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046957	negative phototaxis	PMID:19285485^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17369364^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17369364^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009648	photoperiodism	PMID:17600215^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:17068124^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0031652	P	Seeded From UniProt	complete
involved_in	GO:0042749	regulation of circadian sleep/wake cycle	PMID:16938867^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16410523^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16410523^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:11178250^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007620	copulation	PMID:15324667^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12944510^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12944510^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:12015613^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12015613^[16]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:12015613^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12015613^[16]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:12015603^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030431	sleep	PMID:11715043^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008062	eclosion rhythm	PMID:11715043^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:11715043^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:11715043^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007617	mating behavior	PMID:11470898^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	PMID:11333398^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000678	negative regulation of transcription regulatory region DNA binding	PMID:10409723^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10409723^[21]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0023076	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10409723^[21]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0023076	F	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:10409723^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10417378^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:10417378^[22]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0025680	C	Seeded From UniProt	complete
involved_in	GO:0071482	cellular response to light stimulus	PMID:9697866^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:27489346^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:27489346^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	Reactome:R-DME-432626 PMID:11178250^[13] PMID:15312644^[25] PMID:12154068^[26] PMID:12490253^[27] PMID:12015613^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-538832 Reactome:R-DME-538824 Reactome:R-DME-538822 Reactome:R-DME-432647 Reactome:R-DME-432642 Reactome:R-DME-432590 Reactome:R-DME-432535 Reactome:R-DME-432533 Reactome:R-DME-432507 Reactome:R-DME-432464 Reactome:R-DME-432427 Reactome:R-DME-432426 Reactome:R-DME-432401	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-DME-538904 Reactome:R-DME-538900 Reactome:R-DME-538891 Reactome:R-DME-432642 Reactome:R-DME-432527 Reactome:R-DME-432521 Reactome:R-DME-432513 Reactome:R-DME-432424 Reactome:R-DME-432371	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0042306	regulation of protein import into nucleus	PMID:11178250^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009649	entrainment of circadian clock	PMID:11178250^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:11178250^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15312644^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045187	regulation of circadian sleep/wake cycle, sleep	PMID:12486704^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008062	eclosion rhythm	PMID:12486701^[29] PMID:12111533^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007622	rhythmic behavior	PMID:12486701^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12486701^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Stone, EF et al. (2012) The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 8 e1002445 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Gill, S et al. (2015) Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science 347 1265-9 PubMed GONUTS page
↑ Goda, T et al. (2014) Temperature-dependent resetting of the molecular circadian oscillator in Drosophila. Proc. Biol. Sci. 281 PubMed GONUTS page
↑ Liu, Z & Zhao, Z (2014) Effects of light interruption on sleep and viability of Drosophila melanogaster. PLoS ONE 9 e105678 PubMed GONUTS page
↑ Kaneko, H et al. (2012) Circadian rhythm of temperature preference and its neural control in Drosophila. Curr. Biol. 22 1851-7 PubMed GONUTS page
↑ Gong, Z (2009) Behavioral dissection of Drosophila larval phototaxis. Biochem. Biophys. Res. Commun. 382 395-9 PubMed GONUTS page
↑ ^8.0 ^8.1 Fernández, MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc. Natl. Acad. Sci. U.S.A. 104 5650-5 PubMed GONUTS page
↑ Tauber, E et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316 1895-8 PubMed GONUTS page
↑ Peschel, N et al. (2006) Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc. Natl. Acad. Sci. U.S.A. 103 17313-8 PubMed GONUTS page
↑ Koh, K et al. (2006) A Drosophila model for age-associated changes in sleep:wake cycles. Proc. Natl. Acad. Sci. U.S.A. 103 13843-7 PubMed GONUTS page
↑ ^12.0 ^12.1 Meyer, P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311 226-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Hardin, PE (2000) From biological clock to biological rhythms. Genome Biol. 1 REVIEWS1023 PubMed GONUTS page
↑ Beaver, LM & Giebultowicz, JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14 1492-7 PubMed GONUTS page
↑ ^15.0 ^15.1 Ashmore, LJ et al. (2003) Novel insights into the regulation of the timeless protein. J. Neurosci. 23 7810-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Panda, S et al. (2002) Circadian rhythms from flies to human. Nature 417 329-35 PubMed GONUTS page
↑ Shaw, PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417 287-91 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page
↑ Sakai, T & Ishida, N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 98 9221-5 PubMed GONUTS page
↑ Wang, GK et al. (2001) Regulation of the cycling of timeless (tim) RNA. J. Neurobiol. 47 161-75 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Lee, C et al. (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol. Cell. Biol. 19 5316-25 PubMed GONUTS page
↑ ^22.0 ^22.1 Ceriani, MF et al. (1999) Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 285 553-6 PubMed GONUTS page
↑ Suri, V et al. (1998) Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron 21 225-34 PubMed GONUTS page
↑ ^24.0 ^24.1 Lee, E et al. (2016) Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc. Natl. Acad. Sci. U.S.A. 113 E4904-13 PubMed GONUTS page
↑ ^25.0 ^25.1 Emery, P & Reppert, SM (2004) A rhythmic Ror. Neuron 43 443-6 PubMed GONUTS page
↑ Glossop, NR & Hardin, PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell. Sci. 115 3369-77 PubMed GONUTS page
↑ Rothenfluh, A & Heberlein, U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr. Opin. Neurobiol. 12 639-45 PubMed GONUTS page
↑ Shaw, PJ & Franken, P (2003) Perchance to dream: solving the mystery of sleep through genetic analysis. J. Neurobiol. 54 179-202 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page
↑ Stanewsky, R (2002) Clock mechanisms in Drosophila. Cell Tissue Res. 309 11-26 PubMed GONUTS page

[PMID:22253593-1] 1.0 ^1.1 ^1.2 ^1.3 Stone, EF et al. (2012) The circadian clock protein timeless regulates phagocytosis of bacteria in Drosophila. PLoS Pathog. 8 e1002445 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25766238-3] Gill, S et al. (2015) Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Science 347 1265-9 PubMed GONUTS page

[PMID:25165772-4] Goda, T et al. (2014) Temperature-dependent resetting of the molecular circadian oscillator in Drosophila. Proc. Biol. Sci. 281 PubMed GONUTS page

[PMID:25148297-5] Liu, Z & Zhao, Z (2014) Effects of light interruption on sleep and viability of Drosophila melanogaster. PLoS ONE 9 e105678 PubMed GONUTS page

[PMID:22981774-6] Kaneko, H et al. (2012) Circadian rhythm of temperature preference and its neural control in Drosophila. Curr. Biol. 22 1851-7 PubMed GONUTS page

[PMID:19285485-7] Gong, Z (2009) Behavioral dissection of Drosophila larval phototaxis. Biochem. Biophys. Res. Commun. 382 395-9 PubMed GONUTS page

[PMID:17369364-8] 8.0 ^8.1 Fernández, MP et al. (2007) Impaired clock output by altered connectivity in the circadian network. Proc. Natl. Acad. Sci. U.S.A. 104 5650-5 PubMed GONUTS page

[PMID:17600215-9] Tauber, E et al. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316 1895-8 PubMed GONUTS page

[PMID:17068124-10] Peschel, N et al. (2006) Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock. Proc. Natl. Acad. Sci. U.S.A. 103 17313-8 PubMed GONUTS page

[PMID:16938867-11] Koh, K et al. (2006) A Drosophila model for age-associated changes in sleep:wake cycles. Proc. Natl. Acad. Sci. U.S.A. 103 13843-7 PubMed GONUTS page

[PMID:16410523-12] 12.0 ^12.1 Meyer, P et al. (2006) PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock. Science 311 226-9 PubMed GONUTS page

[PMID:11178250-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Hardin, PE (2000) From biological clock to biological rhythms. Genome Biol. 1 REVIEWS1023 PubMed GONUTS page

[PMID:15324667-14] Beaver, LM & Giebultowicz, JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14 1492-7 PubMed GONUTS page

[PMID:12944510-15] 15.0 ^15.1 Ashmore, LJ et al. (2003) Novel insights into the regulation of the timeless protein. J. Neurosci. 23 7810-9 PubMed GONUTS page

[PMID:12015613-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Panda, S et al. (2002) Circadian rhythms from flies to human. Nature 417 329-35 PubMed GONUTS page

[PMID:12015603-17] Shaw, PJ et al. (2002) Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417 287-91 PubMed GONUTS page

[PMID:11715043-18] 18.0 ^18.1 ^18.2 ^18.3 Sokolowski, MB (2001) Drosophila: genetics meets behaviour. Nat. Rev. Genet. 2 879-90 PubMed GONUTS page

[PMID:11470898-19] Sakai, T & Ishida, N (2001) Circadian rhythms of female mating activity governed by clock genes in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 98 9221-5 PubMed GONUTS page

[PMID:11333398-20] Wang, GK et al. (2001) Regulation of the cycling of timeless (tim) RNA. J. Neurobiol. 47 161-75 PubMed GONUTS page

[PMID:10409723-21] 21.0 ^21.1 ^21.2 ^21.3 Lee, C et al. (1999) PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol. Cell. Biol. 19 5316-25 PubMed GONUTS page

[PMID:10417378-22] 22.0 ^22.1 Ceriani, MF et al. (1999) Light-dependent sequestration of TIMELESS by CRYPTOCHROME. Science 285 553-6 PubMed GONUTS page

[PMID:9697866-23] Suri, V et al. (1998) Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Neuron 21 225-34 PubMed GONUTS page

[PMID:27489346-24] 24.0 ^24.1 Lee, E et al. (2016) Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc. Natl. Acad. Sci. U.S.A. 113 E4904-13 PubMed GONUTS page

[PMID:15312644-25] 25.0 ^25.1 Emery, P & Reppert, SM (2004) A rhythmic Ror. Neuron 43 443-6 PubMed GONUTS page

[PMID:12154068-26] Glossop, NR & Hardin, PE (2002) Central and peripheral circadian oscillator mechanisms in flies and mammals. J. Cell. Sci. 115 3369-77 PubMed GONUTS page

[PMID:12490253-27] Rothenfluh, A & Heberlein, U (2002) Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion. Curr. Opin. Neurobiol. 12 639-45 PubMed GONUTS page

[PMID:12486704-28] Shaw, PJ & Franken, P (2003) Perchance to dream: solving the mystery of sleep through genetic analysis. J. Neurobiol. 54 179-202 PubMed GONUTS page

[PMID:12486701-29] 29.0 ^29.1 ^29.2 Stanewsky, R (2003) Genetic analysis of the circadian system in Drosophila melanogaster and mammals. J. Neurobiol. 54 111-47 PubMed GONUTS page

[PMID:12111533-30] Stanewsky, R (2002) Clock mechanisms in Drosophila. Cell Tissue Res. 309 11-26 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

DROME:TIM

Contents

Annotations

Notes

References

a

b

c

d

e

h

i

l

m

n

o

p

r

s

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools