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PMID:17600215
| Citation |
Tauber, E, Zordan, M, Sandrelli, F, Pegoraro, M, Osterwalder, N, Breda, C, Daga, A, Selmin, A, Monger, K, Benna, C, Rosato, E, Kyriacou, CP and Costa, R (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science 316:1895-8 |
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| Abstract |
Circadian and other natural clock-like endogenous rhythms may have evolved to anticipate regular temporal changes in the environment. We report that a mutation in the circadian clock gene timeless in Drosophila melanogaster has arisen and spread by natural selection relatively recently in Europe. We found that, when introduced into different genetic backgrounds, natural and artificial alleles of the timeless gene affect the incidence of diapause in response to changes in light and temperature. The natural mutant allele alters an important life history trait that may enhance the fly's adaptation to seasonal conditions. |
| Links |
PubMed Online version:10.1126/science.1138412 |
| Keywords |
Alleles; Amino Acid Sequence; Animals; Base Sequence; Circadian Rhythm/genetics; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Europe; Evolution, Molecular; Female; Geography; Haplotypes; Molecular Sequence Data; Mutation; Photoperiod; Phylogeny; Polymorphism, Genetic; Protein Isoforms/genetics; Protein Isoforms/physiology; Reproduction; Seasons; Selection, Genetic; Temperature; Transformation, Genetic |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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