GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:15324667
| Citation |
Beaver, LM and Giebultowicz, JM (2004) Regulation of copulation duration by period and timeless in Drosophila melanogaster. Curr. Biol. 14:1492-7 |
|---|---|
| Abstract |
The circadian clock involves several clock genes encoding interacting transcriptional regulators. Mutations in clock genes in Drosophila melanogaster, period (per), timeless (tim), Clock (Clk), and cycle (cyc), produce multiple phenotypes associated with physiology, behavior, development, and morphology. It is not clear whether these genes always work as clock components or may also act in some unknown pleiotropic fashion. We report here that per and tim are involved in a novel, male-specific phenotype that affects behavioral timing on the order of minutes. Males lacking per or tim copulate significantly longer than males with normal per or tim function, while females do not show this effect. No correlation between fertility and extended copulation duration was found. Several lines of evidence suggest that the time in copula (TIC) is not regulated by the known clock mechanism. First, the period of free-running clock oscillations does not appear to affect this phenotype. Second, constant light, which abolishes the clock function, does not alter TIC. Finally, mutations in the positively acting clock transcription factors, Clk and cyc, do not affect TIC. Our study extends the repertoire of behavioral functions involving per and tim genes and uncovers another time scale over which these genes may act. |
| Links |
PubMed Online version:10.1016/j.cub.2004.08.022 |
| Keywords |
ARNTL Transcription Factors; Age Factors; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks/genetics; Biological Clocks/physiology; CLOCK Proteins; Circadian Rhythm/genetics; Circadian Rhythm/physiology; Copulation/physiology; Drosophila Proteins/genetics; Drosophila melanogaster/physiology; Fertility/physiology; Male; Mutation/genetics; Nuclear Proteins/genetics; Period Circadian Proteins; Time Factors; Trans-Activators/genetics; Transcription Factors/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
