DROME:P91634

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	No Information Provided. (synonyms: dp110 (ECO:0000313 with EMBL:ABG88073.1))
Protein Name(s)	PI-3 kinase (ECO:0000313 with EMBL:ABG88073.1) Phosphoinositide 3-kinase, Dp110 (ECO:0000313 with EMBL:CAA70291.1) Pi3K92E, isoform A (ECO:0000313 with EMBL:AAF55792.1) Pi3K92E, isoform B (ECO:0000313 with EMBL:AAN14359.1) Pi3K92E, isoform C (ECO:0000313 with EMBL:AGB96150.1) Putative uncharacterized protein Pi3K92E (ECO:0000313 with EMBL:CCB63076.1) SD05105p (ECO:0000313 with EMBL:AAO24928.1)
External Links
UniProt	P91634
EMBL	AE014297 AE014297 BT003173 DQ792599 DQ792600 AE014297 Y09070 FR870118 FR870119 FR870121 FR870122 FR870124 FR870125 FR870126 FR870127 FR870128
PIR	T13950
RefSeq	NP_001262770.1 NP_650902.1 NP_732536.1
UniGene	Dm.1876
DIP	DIP-21625N
MINT	MINT-935585
STRING	7227.FBpp0083348
EnsemblMetazoa	FBtr0083940 FBtr0083941 FBtr0334643
GeneID	42446
KEGG	dme:Dmel_CG4141
UCSC	CG4141-RA
CTD	42446
FlyBase	FBgn0015279
eggNOG	COG5032 KOG0904
GeneTree	ENSGT00760000119110
KO	K00922
OMA	DIFHELP
OrthoDB	EOG70CR65
BRENDA	2.7.1.137
Reactome	R-DME-109704 R-DME-114604 R-DME-1257604 R-DME-1660499 R-DME-198203 R-DME-210993 R-DME-2730905 R-DME-4420097 R-DME-912631 R-DME-983695
GenomeRNAi	42446
NextBio	828825
Proteomes	UP000000803
GO	GO:0005622 GO:0005943 GO:0016303 GO:0035005 GO:0001727 GO:0035004 GO:0046934 GO:0017124 GO:0006914 GO:0005975 GO:0016049 GO:0009267 GO:0048813 GO:0055115 GO:0007390 GO:0002168 GO:0008286 GO:0036335 GO:0002164 GO:0030536 GO:0007436 GO:0006629 GO:0007552 GO:0035264 GO:0010507 GO:0042059 GO:0016322 GO:0048477 GO:0030707 GO:0046854 GO:0036092 GO:0048015 GO:0016310 GO:0030307 GO:0045793 GO:0045927 GO:0045572 GO:0046622 GO:0045727 GO:0042127 GO:0008361 GO:0050773 GO:0048169 GO:0007346 GO:0040014 GO:0046620 GO:2000377 GO:0051823 GO:0006979 GO:0060074 GO:0051124
Gene3D	1.10.1070.11 1.25.40.70 2.60.40.150
InterPro	IPR016024 IPR000008 IPR011009 IPR000403 IPR018936 IPR003113 IPR002420 IPR000341 IPR015433 IPR001263 IPR029071
PANTHER	PTHR10048
Pfam	PF00454 PF00792 PF02192 PF00794 PF00613
SMART	SM00142 SM00143 SM00144 SM00145 SM00146
SUPFAM	SSF48371 SSF49562 SSF54236 SSF56112
PROSITE	PS00915 PS00916 PS50290 PS51544 PS51547 PS51546 PS51545

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:17021175^[1]	ECO:0000314			P		Figure 2A shows an increase in synapse number after expression of PI3K	complete CACAO 11249
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:30540251^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9VA37	P		Seeded From UniProt	complete
involved_in	GO:0048167	regulation of synaptic plasticity	PMID:30540251^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:620899 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015277 FB:FBgn0015278 FB:FBgn0015279 FB:FBgn0267350 MGI:MGI:2448506 PANTHER:PTN000005673 RGD:620916 RGD:620917 SGD:S000004230 SGD:S000004296 SGD:S000005211 UniProtKB:A0A1D8PDV7 UniProtKB:P32871	P		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203729 MGI:MGI:2685045 PANTHER:PTN000005674 WB:WBGene00009552	P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 PANTHER:PTN000005674 RGD:620231	F		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1922019 PANTHER:PTN000799655	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 UniProtKB:O42391	P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015278 FB:FBgn0015279 MGI:MGI:1203729 MGI:MGI:1206581 MGI:MGI:1922019 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P42336	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 PomBase:SPAC458.05 TAIR:locus:2164401 UniProtKB:P48736	C		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015279 PANTHER:PTN000005674 UniProtKB:O00329 UniProtKB:P42338 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 MGI:MGI:1353576 PANTHER:PTN000799655	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1206581 PANTHER:PTN000005674 RGD:620916 RGD:620917 UniProtKB:P32871 WB:WBGene00000090	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005674 RGD:620231 UniProtKB:O00443 UniProtKB:P48736 dictyBase:DDB_G0278727 dictyBase:DDB_G0283081	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000005673 RGD:621214 UniProtKB:O00443 UniProtKB:P42356 UniProtKB:P48736 WB:WBGene00000090 WB:WBGene00006932 WB:WBGene00009552 dictyBase:DDB_G0291093	C		Seeded From UniProt	complete
involved_in	GO:0035099	hemocyte migration	PMID:16651377^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0009611)	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:29514084^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:19216764^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003079	P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:19216764^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003079	P		Seeded From UniProt	complete
involved_in	GO:0036099	female germ-line stem cell population maintenance	PMID:29549109^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:22242005^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	PMID:10962553^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(FB:FBgn0010379)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10962553^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:14645523^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10823906^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:10823906^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PMID:8978685^[12]	ECO:0000353	physical interaction evidence used in manual assertion	FB:FBgn0020622	C		Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PMID:8978685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045572	positive regulation of imaginal disc growth	PMID:29719260^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12841848^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904263	positive regulation of TORC1 signaling	PMID:28829944^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:21951762^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:11832249^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:11832249^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000252	negative regulation of feeding behavior	PMID:11832249^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:11832249^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:11832249^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020622,FB:FBgn0026379	P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:9169420^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035004	phosphatidylinositol 3-kinase activity	PMID:9169420^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PMID:9169420^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:25994086^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:27500738^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035212	cell competition in a multicellular organism	PMID:26287461^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030707	ovarian follicle cell development	PMID:26205122^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036335	intestinal stem cell homeostasis	PMID:25367037^[23]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0262458	P		Seeded From UniProt	complete
involved_in	GO:1904801	positive regulation of neuron remodeling	PMID:24068890^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051823	regulation of synapse structural plasticity	PMID:22954894^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	PMID:22555456^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:22319582^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007346	regulation of mitotic cell cycle	PMID:21516128^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	PMID:21464442^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	PMID:21464442^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	PMID:21464442^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:20203043^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283499	P		Seeded From UniProt	complete
involved_in	GO:0050773	regulation of dendrite development	PMID:19778508^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:19540338^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:19540338^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:17371599^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007390	germ-band shortening	PMID:16774996^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:17041587^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:17041587^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045572	positive regulation of imaginal disc growth	PMID:17041587^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:17021175^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:17021175^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060074	synapse maturation	PMID:17021175^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055115	entry into diapause	PMID:17043223^[36]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:16155123^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007552	metamorphosis	PMID:16182527^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002164	larval development	PMID:16182527^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	PMID:16182527^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	PMID:16182526^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002168	instar larval development	PMID:16182526^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030536	larval feeding behavior	PMID:16150727^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007436	larval salivary gland morphogenesis	PMID:15963974^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:15296715^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	PMID:10962553^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008361	regulation of cell size	PMID:10508611^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	PMID:10508611^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045572	positive regulation of imaginal disc growth	PMID:8978685^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	PMID:8978685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:8978685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	PMID:8978685^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:8978685^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008290 InterPro:IPR015433	P		Seeded From UniProt	complete
enables	GO:0052812	phosphatidylinositol-3,4-bisphosphate 5-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F		Seeded From UniProt	complete
enables	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.154	F		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.137	F		Seeded From UniProt	complete
enables	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.153	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000415644	F		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000399976	P		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	Reactome:R-DME-110453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-110453 Reactome:R-DME-110446	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Martín-Peña, A et al. (2006) Age-independent synaptogenesis by phosphoinositide 3 kinase. J. Neurosci. 26 10199-208 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Oswald, MC et al. (2018) Reactive oxygen species regulate activity-dependent neuronal plasticity in . Elife 7 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wood, W et al. (2006) Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J. Cell Biol. 173 405-16 PubMed GONUTS page
↑ Roth, SW et al. (2018) Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P Production and Akt Activation. Cell Rep 22 2550-2556 PubMed GONUTS page
↑ ^6.0 ^6.1 Sims, D et al. (2009) PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 10 R20 PubMed GONUTS page
↑ Su, YH et al. (2018) Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling. Development 145 PubMed GONUTS page
↑ Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page
↑ Miron, M et al. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23 9117-26 PubMed GONUTS page
↑ ^11.0 ^11.1 Clemens, JC et al. (2000) Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. U.S.A. 97 6499-503 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Leevers, SJ et al. (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15 6584-94 PubMed GONUTS page
↑ Gerlach, SU et al. (2018) Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure. Cell Rep 23 1491-1503 PubMed GONUTS page
↑ Lizcano, JM et al. (2003) Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374 297-306 PubMed GONUTS page
↑ Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page
↑ Parisi, F et al. (2011) Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 9 65 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Britton, JS et al. (2002) Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2 239-49 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Weinkove, D et al. (1997) p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110. J. Biol. Chem. 272 14606-10 PubMed GONUTS page
↑ Ugrankar, R et al. (2015) Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Nat Commun 6 7102 PubMed GONUTS page
↑ Cinnamon, E et al. (2016) Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet. 12 e1006154 PubMed GONUTS page
↑ Levayer, R et al. (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature 524 476-80 PubMed GONUTS page
↑ Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page
↑ Foronda, D et al. (2014) Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. Genes Dev. 28 2421-31 PubMed GONUTS page
↑ Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page
↑ Mozer, BA & Sandstrom, DJ (2012) Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase. Mol. Cell. Neurosci. 51 89-100 PubMed GONUTS page
↑ Denton, D et al. (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 19 1299-307 PubMed GONUTS page
↑ Dimitroff, B et al. (2012) Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS ONE 7 e30722 PubMed GONUTS page
↑ Willecke, M et al. (2011) Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. Oncogene 30 4067-74 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Murillo-Maldonado, JM et al. (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60 1632-6 PubMed GONUTS page
↑ Lee, JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327 1223-8 PubMed GONUTS page
↑ Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page
↑ ^32.0 ^32.1 Wu, H et al. () JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126 624-37 PubMed GONUTS page
↑ Hall, DJ et al. (2007) Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol. 5 10 PubMed GONUTS page
↑ Herranz, H et al. (2006) calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development 133 2617-25 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Orme, MH et al. (2006) Input from Ras is required for maximal PI(3)K signalling in Drosophila. Nat. Cell Biol. 8 1298-302 PubMed GONUTS page
↑ Williams, KD et al. (2006) Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103 15911-5 PubMed GONUTS page
↑ Yang, Y et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U.S.A. 102 13670-5 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Mirth, C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 1796-807 PubMed GONUTS page
↑ ^39.0 ^39.1 Caldwell, PE et al. (2005) Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release. Curr. Biol. 15 1785-95 PubMed GONUTS page
↑ Wu, Q et al. (2005) Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 102 13289-94 PubMed GONUTS page
↑ Takeo, S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284 204-18 PubMed GONUTS page
↑ Rusten, TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 179-92 PubMed GONUTS page
↑ ^43.0 ^43.1 Weinkove, D et al. (1999) Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol. 9 1019-29 PubMed GONUTS page

[PMID:17021175-1] 1.0 ^1.1 ^1.2 ^1.3 Martín-Peña, A et al. (2006) Age-independent synaptogenesis by phosphoinositide 3 kinase. J. Neurosci. 26 10199-208 PubMed GONUTS page

[PMID:30540251-2] 2.0 ^2.1 ^2.2 Oswald, MC et al. (2018) Reactive oxygen species regulate activity-dependent neuronal plasticity in . Elife 7 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16651377-4] Wood, W et al. (2006) Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J. Cell Biol. 173 405-16 PubMed GONUTS page

[PMID:29514084-5] Roth, SW et al. (2018) Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P Production and Akt Activation. Cell Rep 22 2550-2556 PubMed GONUTS page

[PMID:19216764-6] 6.0 ^6.1 Sims, D et al. (2009) PDGF/VEGF signaling controls cell size in Drosophila. Genome Biol. 10 R20 PubMed GONUTS page

[PMID:29549109-7] Su, YH et al. (2018) Diet regulates membrane extension and survival of niche escort cells for germline homeostasis via insulin signaling. Development 145 PubMed GONUTS page

[PMID:22242005-8] Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page

[PMID:10962553-9] 9.0 ^9.1 ^9.2 Scanga, SE et al. (2000) The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila. Oncogene 19 3971-7 PubMed GONUTS page

[PMID:14645523-10] Miron, M et al. (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol. Cell. Biol. 23 9117-26 PubMed GONUTS page

[PMID:10823906-11] 11.0 ^11.1 Clemens, JC et al. (2000) Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc. Natl. Acad. Sci. U.S.A. 97 6499-503 PubMed GONUTS page

[PMID:8978685-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 Leevers, SJ et al. (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15 6584-94 PubMed GONUTS page

[PMID:29719260-13] Gerlach, SU et al. (2018) Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure. Cell Rep 23 1491-1503 PubMed GONUTS page

[PMID:12841848-14] Lizcano, JM et al. (2003) Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374 297-306 PubMed GONUTS page

[PMID:28829944-15] Kim, W et al. (2017) Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye. Dev. Cell 42 363-375.e4 PubMed GONUTS page

[PMID:21951762-16] Parisi, F et al. (2011) Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo. BMC Biol. 9 65 PubMed GONUTS page

[PMID:11832249-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Britton, JS et al. (2002) Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2 239-49 PubMed GONUTS page

[PMID:9169420-18] 18.0 ^18.1 ^18.2 Weinkove, D et al. (1997) p60 is an adaptor for the Drosophila phosphoinositide 3-kinase, Dp110. J. Biol. Chem. 272 14606-10 PubMed GONUTS page

[PMID:25994086-19] Ugrankar, R et al. (2015) Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism. Nat Commun 6 7102 PubMed GONUTS page

[PMID:27500738-20] Cinnamon, E et al. (2016) Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet. 12 e1006154 PubMed GONUTS page

[PMID:26287461-21] Levayer, R et al. (2015) Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature 524 476-80 PubMed GONUTS page

[PMID:26205122-22] Jia, D et al. (2015) A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. Sci Rep 5 12328 PubMed GONUTS page

[PMID:25367037-23] Foronda, D et al. (2014) Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. Genes Dev. 28 2421-31 PubMed GONUTS page

[PMID:24068890-24] Wong, JJ et al. (2013) A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning. PLoS Biol. 11 e1001657 PubMed GONUTS page

[PMID:22954894-25] Mozer, BA & Sandstrom, DJ (2012) Drosophila neuroligin 1 regulates synaptic growth and function in response to activity and phosphoinositide-3-kinase. Mol. Cell. Neurosci. 51 89-100 PubMed GONUTS page

[PMID:22555456-26] Denton, D et al. (2012) Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. Cell Death Differ. 19 1299-307 PubMed GONUTS page

[PMID:22319582-27] Dimitroff, B et al. (2012) Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS ONE 7 e30722 PubMed GONUTS page

[PMID:21516128-28] Willecke, M et al. (2011) Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. Oncogene 30 4067-74 PubMed GONUTS page

[PMID:21464442-29] 29.0 ^29.1 ^29.2 Murillo-Maldonado, JM et al. (2011) Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 60 1632-6 PubMed GONUTS page

[PMID:20203043-30] Lee, JH et al. (2010) Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science 327 1223-8 PubMed GONUTS page

[PMID:19778508-31] Parrish, JZ et al. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. Neuron 63 788-802 PubMed GONUTS page

[PMID:19540338-32] 32.0 ^32.1 Wu, H et al. () JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy. Mech. Dev. 126 624-37 PubMed GONUTS page

[PMID:17371599-33] Hall, DJ et al. (2007) Rheb-TOR signaling promotes protein synthesis, but not glucose or amino acid import, in Drosophila. BMC Biol. 5 10 PubMed GONUTS page

[PMID:16774996-34] Herranz, H et al. (2006) calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues. Development 133 2617-25 PubMed GONUTS page

[PMID:17041587-35] 35.0 ^35.1 ^35.2 Orme, MH et al. (2006) Input from Ras is required for maximal PI(3)K signalling in Drosophila. Nat. Cell Biol. 8 1298-302 PubMed GONUTS page

[PMID:17043223-36] Williams, KD et al. (2006) Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc. Natl. Acad. Sci. U.S.A. 103 15911-5 PubMed GONUTS page

[PMID:16155123-37] Yang, Y et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U.S.A. 102 13670-5 PubMed GONUTS page

[PMID:16182527-38] 38.0 ^38.1 ^38.2 Mirth, C et al. (2005) The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 1796-807 PubMed GONUTS page

[PMID:16182526-39] 39.0 ^39.1 Caldwell, PE et al. (2005) Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release. Curr. Biol. 15 1785-95 PubMed GONUTS page

[PMID:16150727-40] Wu, Q et al. (2005) Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila. Proc. Natl. Acad. Sci. U.S.A. 102 13289-94 PubMed GONUTS page

[PMID:15963974-41] Takeo, S et al. (2005) Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev. Biol. 284 204-18 PubMed GONUTS page

[PMID:15296715-42] Rusten, TE et al. (2004) Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev. Cell 7 179-92 PubMed GONUTS page

[PMID:10508611-43] 43.0 ^43.1 Weinkove, D et al. (1999) Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol. 9 1019-29 PubMed GONUTS page

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