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PMID:10508611
| Citation |
Weinkove, D, Neufeld, TP, Twardzik, T, Waterfield, MD and Leevers, SJ (1999) Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr. Biol. 9:1019-29 |
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| Abstract |
Class I(A) phosphoinositide 3-kinases (PI 3-kinases) have been implicated in the regulation of several cellular processes including cell division, cell survival and protein synthesis. The size of Drosophila imaginal discs (epithelial structures that give rise to adult organs) is maintained by factors that can compensate for experimentally induced changes in these PI 3-kinase-regulated processes. Overexpression of the gene encoding the Drosophila class I(A) PI 3-kinase, Dp110, in imaginal discs, however, results in enlarged adult organs. These observations have led us to investigate the role of Dp100 and its adaptor, p60, in the control of imaginal disc cell size, cell number and organ size. |
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| Keywords |
Animals; Cell Count; Cell Size; Drosophila Proteins; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Drosophila melanogaster/physiology; Embryo, Nonmammalian/cytology; Gene Expression Regulation, Developmental; Gene Targeting; Genetic Complementation Test; Insect Proteins/genetics; Insect Proteins/physiology; Isoenzymes/genetics; Isoenzymes/physiology; Larva/cytology; Larva/growth & development; Morphogenesis/genetics; Morphogenesis/physiology; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/physiology; Recombinant Fusion Proteins/physiology; Signal Transduction; Wing/embryology; src Homology Domains |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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