DROME:FOXO

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	foxo (ECO:0000312 with EMBL:AAS65148.1) (synonyms: Afx)
Protein Name(s)	Forkhead box protein O (ECO:0000303 with PMID:12893776^[1]) dFOXO (ECO:0000303 with PMID:12893776^[1]) Protein FKHR
External Links
UniProt	Q95V55
EMBL	AF426831 AF416728 AE014297 AE014297 AE014297 AE014297 AY058718 AY089542
RefSeq	NP_001262557.1 NP_650330.3 NP_996204.1 NP_996205.1
UniGene	Dm.3957
ProteinModelPortal	Q95V55
SMR	Q95V55
BioGrid	66786
IntAct	Q95V55
MINT	MINT-831229
PaxDb	Q95V55
PRIDE	Q95V55
EnsemblMetazoa	FBtr0082886 FBtr0082887
GeneID	41709
KEGG	dme:Dmel_CG3143
UCSC	CG3143-RB
CTD	41709
FlyBase	FBgn0038197
eggNOG	NOG302607
GeneTree	ENSGT00390000000589
HOGENOM	HOG000229954
InParanoid	Q95V55
OrthoDB	EOG79GT6N
Reactome	REACT_181688 REACT_184384 REACT_235896 REACT_250535
SignaLink	Q95V55
ChiTaRS	foxo
GenomeRNAi	41709
NextBio	825163
Proteomes	UP000000803
Bgee	Q95V55
GO	GO:0005737 GO:0005829 GO:0005634 GO:0031490 GO:0003677 GO:0001077 GO:0043565 GO:0003700 GO:0006171 GO:0007049 GO:0034198 GO:0006974 GO:0034599 GO:0009267 GO:0007623 GO:0001745 GO:0048813 GO:0008340 GO:0036099 GO:0042593 GO:0005977 GO:0007476 GO:0008286 GO:0045475 GO:0001578 GO:0010259 GO:0007520 GO:0030308 GO:0008285 GO:0045792 GO:0046627 GO:0010888 GO:0040015 GO:0045892 GO:1900078 GO:2000253 GO:2000130 GO:0045944 GO:0045893 GO:0032925 GO:0010506 GO:0001558 GO:0040008 GO:0035206 GO:0046626 GO:0019216 GO:0016241 GO:0006355 GO:0009617 GO:0006979 GO:0007525
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	17686972	ECO:0000314			C		Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls	Missing: reference
	GO:0005737	cytoplasm	17686972	ECO:0000314			C		Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls	Missing: reference
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:12893776^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:18234213^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:18234213^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010259	multicellular organism aging	PMID:15175753^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12893776^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12893776^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:12893776^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:12893776^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:12893776^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:12893776^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:22242005^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010898	positive regulation of triglyceride catabolic process	PMID:21565616^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21565616^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21565616^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21565616^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21565616^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:21565616^[7]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	PMID:25421296^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040014	regulation of multicellular organism growth	PMID:25421296^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006697	ecdysone biosynthetic process	PMID:25421296^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:25421296^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:25232726^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0000097	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:25232726^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003118	P		Seeded From UniProt	complete
involved_in	GO:2000130	positive regulation of octopamine signaling pathway	PMID:24690889^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045475	locomotor rhythm	PMID:24690889^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283499	P		Seeded From UniProt	complete
involved_in	GO:0007520	myoblast fusion	PMID:24191061^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007525	somatic muscle development	PMID:24191061^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24244197^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24244197^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:24244197^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032925	regulation of activin receptor signaling pathway	PMID:24244197^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010888	negative regulation of lipid storage	PMID:24035390^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036099	female germ-line stem cell population maintenance	PMID:23895933^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	PMID:23977298^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000253	positive regulation of feeding behavior	PMID:22876196^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000253	positive regulation of feeding behavior	PMID:22876196^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0259168	P		Seeded From UniProt	complete
involved_in	GO:0001578	microtubule bundle formation	PMID:22312004^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:17895391^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:17895391^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:19237508^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035206	regulation of hemocyte proliferation	PMID:20688956^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20888228^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:20888228^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20888228^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19651894^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:19651894^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:17363962^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16564014^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001745	compound eye morphogenesis	PMID:15843412^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:15192154^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:15175753^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:15175753^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0024248	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010379	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0026379	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0015279	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283499	P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:12908874^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12908874^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0026317	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12893776^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:12893776^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0010379	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	PMID:18665908^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0020238	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:18650956^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18234213^[2]	ECO:0000305	curator inference used in manual assertion	GO:0001228	C		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:18234213^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:18234213^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18177722^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009267	cellular response to starvation	PMID:18177722^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:18177722^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	PMID:17055976^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	PMID:17055976^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:17363962^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	PMID:12844367^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12844367^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040015	negative regulation of multicellular organism growth	PMID:12844367^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:27525480^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(FB:FBgn0261560)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:27525480^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:29529025^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061965	positive regulation of entry into reproductive diapause	PMID:27689881^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070345	negative regulation of fat cell proliferation	PMID:19822665^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-DME-110475	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Puig, O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 2006-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Vihervaara, T & Puig, O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J. Mol. Biol. 376 1215-23 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Jünger, MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2 20 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Hwangbo, DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 562-6 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Wang, B et al. (2011) A hormone-dependent module regulating energy balance. Cell 145 596-606 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Koyama, T et al. (2014) Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis. Elife 3 PubMed GONUTS page
↑ ^9.0 ^9.1 Alic, N et al. (2014) Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster. PLoS Genet. 10 e1004619 PubMed GONUTS page
↑ ^10.0 ^10.1 Metaxakis, A et al. (2014) Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila. PLoS Biol. 12 e1001824 PubMed GONUTS page
↑ ^11.0 ^11.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Bai, H et al. (2013) Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. PLoS Genet. 9 e1003941 PubMed GONUTS page
↑ Karpac, J et al. (2013) Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep 4 1250-61 PubMed GONUTS page
↑ Yang, SA et al. (2013) FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Dev. Biol. 382 124-35 PubMed GONUTS page
↑ Iyer, EP et al. (2013) Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. PLoS ONE 8 e72434 PubMed GONUTS page
↑ ^16.0 ^16.1 Hong, SH et al. (2012) Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 8 e1002857 PubMed GONUTS page
↑ Nechipurenko, IV & Broihier, HT (2012) FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. J. Cell Biol. 196 345-62 PubMed GONUTS page
↑ ^18.0 ^18.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page
↑ Wagner, C et al. (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23 2045-54 PubMed GONUTS page
↑ Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Francis, VA et al. (2010) dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr. Biol. 20 1799-808 PubMed GONUTS page
↑ ^22.0 ^22.1 Mattila, J et al. (2009) Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Mol. Cell. Biol. 29 5357-65 PubMed GONUTS page
↑ ^23.0 ^23.1 Juhász, G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 14 1181-90 PubMed GONUTS page
↑ Betschinger, J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124 1241-53 PubMed GONUTS page
↑ Goberdhan, DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132 2365-75 PubMed GONUTS page
↑ Giannakou, ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 361 PubMed GONUTS page
↑ Nielsen, MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7 688-99 PubMed GONUTS page
↑ Kramer, JM et al. (2008) foxo is required for resistance to amino acid starvation in Drosophila. Genome 51 668-72 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Teleman, AA et al. (2008) Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 7 21-32 PubMed GONUTS page
↑ ^30.0 ^30.1 Dionne, MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 16 1977-85 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Kramer, JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3 5 PubMed GONUTS page
↑ ^32.0 ^32.1 Mahoney, RE et al. (2016) Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery. Elife 5 PubMed GONUTS page
↑ Tas, D et al. (2018) Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons. PLoS Genet. 14 e1007271 PubMed GONUTS page
↑ Schiesari, L et al. () The Insulin-Like Proteins dILPs-2/5 Determine Diapause Inducibility in Drosophila. PLoS ONE 11 e0163680 PubMed GONUTS page
↑ DiAngelo, JR & Birnbaum, MJ (2009) Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol. Cell. Biol. 29 6341-52 PubMed GONUTS page

[PMID:12893776-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Puig, O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 2006-20 PubMed GONUTS page

[PMID:18234213-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Vihervaara, T & Puig, O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J. Mol. Biol. 376 1215-23 PubMed GONUTS page

[PMID:12908874-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Jünger, MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2 20 PubMed GONUTS page

[PMID:15175753-4] 4.0 ^4.1 ^4.2 Hwangbo, DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 562-6 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22242005-6] Zhang, W et al. (2011) MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 7 e1002429 PubMed GONUTS page

[PMID:21565616-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Wang, B et al. (2011) A hormone-dependent module regulating energy balance. Cell 145 596-606 PubMed GONUTS page

[PMID:25421296-8] 8.0 ^8.1 ^8.2 ^8.3 Koyama, T et al. (2014) Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis. Elife 3 PubMed GONUTS page

[PMID:25232726-9] 9.0 ^9.1 Alic, N et al. (2014) Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster. PLoS Genet. 10 e1004619 PubMed GONUTS page

[PMID:24690889-10] 10.0 ^10.1 Metaxakis, A et al. (2014) Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila. PLoS Biol. 12 e1001824 PubMed GONUTS page

[PMID:24191061-11] 11.0 ^11.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page

[PMID:24244197-12] 12.0 ^12.1 ^12.2 ^12.3 Bai, H et al. (2013) Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. PLoS Genet. 9 e1003941 PubMed GONUTS page

[PMID:24035390-13] Karpac, J et al. (2013) Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep 4 1250-61 PubMed GONUTS page

[PMID:23895933-14] Yang, SA et al. (2013) FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Dev. Biol. 382 124-35 PubMed GONUTS page

[PMID:23977298-15] Iyer, EP et al. (2013) Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. PLoS ONE 8 e72434 PubMed GONUTS page

[PMID:22876196-16] 16.0 ^16.1 Hong, SH et al. (2012) Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 8 e1002857 PubMed GONUTS page

[PMID:22312004-17] Nechipurenko, IV & Broihier, HT (2012) FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. J. Cell Biol. 196 345-62 PubMed GONUTS page

[PMID:17895391-18] 18.0 ^18.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page

[PMID:19237508-19] Wagner, C et al. (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23 2045-54 PubMed GONUTS page

[PMID:20688956-20] Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page

[PMID:20888228-21] 21.0 ^21.1 ^21.2 Francis, VA et al. (2010) dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr. Biol. 20 1799-808 PubMed GONUTS page

[PMID:19651894-22] 22.0 ^22.1 Mattila, J et al. (2009) Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Mol. Cell. Biol. 29 5357-65 PubMed GONUTS page

[PMID:17363962-23] 23.0 ^23.1 Juhász, G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 14 1181-90 PubMed GONUTS page

[PMID:16564014-24] Betschinger, J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124 1241-53 PubMed GONUTS page

[PMID:15843412-25] Goberdhan, DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132 2365-75 PubMed GONUTS page

[PMID:15192154-26] Giannakou, ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 361 PubMed GONUTS page

[PMID:18665908-27] Nielsen, MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7 688-99 PubMed GONUTS page

[PMID:18650956-28] Kramer, JM et al. (2008) foxo is required for resistance to amino acid starvation in Drosophila. Genome 51 668-72 PubMed GONUTS page

[PMID:18177722-29] 29.0 ^29.1 ^29.2 Teleman, AA et al. (2008) Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 7 21-32 PubMed GONUTS page

[PMID:17055976-30] 30.0 ^30.1 Dionne, MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 16 1977-85 PubMed GONUTS page

[PMID:12844367-31] 31.0 ^31.1 ^31.2 Kramer, JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3 5 PubMed GONUTS page

[PMID:27525480-32] 32.0 ^32.1 Mahoney, RE et al. (2016) Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery. Elife 5 PubMed GONUTS page

[PMID:29529025-33] Tas, D et al. (2018) Parallel roles of transcription factors dFOXO and FER2 in the development and maintenance of dopaminergic neurons. PLoS Genet. 14 e1007271 PubMed GONUTS page

[PMID:27689881-34] Schiesari, L et al. () The Insulin-Like Proteins dILPs-2/5 Determine Diapause Inducibility in Drosophila. PLoS ONE 11 e0163680 PubMed GONUTS page

[PMID:19822665-35] DiAngelo, JR & Birnbaum, MJ (2009) Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol. Cell. Biol. 29 6341-52 PubMed GONUTS page

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