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DROME:FOXO

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) foxo (ECO:0000312 with EMBL:AAS65148.1) (synonyms: Afx)
Protein Name(s) Forkhead box protein O (ECO:0000303 with PMID:12893776[1])

dFOXO (ECO:0000303 with PMID:12893776[1]) Protein FKHR

External Links
UniProt Q95V55
EMBL AF426831
AF416728
AE014297
AE014297
AE014297
AE014297
AY058718
AY089542
RefSeq NP_001262557.1
NP_650330.3
NP_996204.1
NP_996205.1
UniGene Dm.3957
ProteinModelPortal Q95V55
SMR Q95V55
BioGrid 66786
IntAct Q95V55
MINT MINT-831229
PaxDb Q95V55
PRIDE Q95V55
EnsemblMetazoa FBtr0082886
FBtr0082887
GeneID 41709
KEGG dme:Dmel_CG3143
UCSC CG3143-RB
CTD 41709
FlyBase FBgn0038197
eggNOG NOG302607
GeneTree ENSGT00390000000589
HOGENOM HOG000229954
InParanoid Q95V55
OrthoDB EOG79GT6N
Reactome REACT_181688
REACT_184384
REACT_235896
REACT_250535
SignaLink Q95V55
ChiTaRS foxo
GenomeRNAi 41709
NextBio 825163
Proteomes UP000000803
Bgee Q95V55
GO GO:0005737
GO:0005829
GO:0005634
GO:0031490
GO:0003677
GO:0001077
GO:0043565
GO:0003700
GO:0006171
GO:0007049
GO:0034198
GO:0006974
GO:0034599
GO:0009267
GO:0007623
GO:0001745
GO:0048813
GO:0008340
GO:0036099
GO:0042593
GO:0005977
GO:0007476
GO:0008286
GO:0045475
GO:0001578
GO:0010259
GO:0007520
GO:0030308
GO:0008285
GO:0045792
GO:0046627
GO:0010888
GO:0040015
GO:0045892
GO:1900078
GO:2000253
GO:2000130
GO:0045944
GO:0045893
GO:0032925
GO:0010506
GO:0001558
GO:0040008
GO:0035206
GO:0046626
GO:0019216
GO:0016241
GO:0006355
GO:0009617
GO:0006979
GO:0007525
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005634

nucleus

17686972

IDA: Inferred from Direct Assay

C

Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls


Missing: reference

GO:0005737

cytoplasm

17686972

IDA: Inferred from Direct Assay

C

Fig 4A & 4B shows increased nuclear dFoxO localization in DN-Dmp53 expressing cells comparing to cytoplasmic localization in controls


Missing: reference

GO:0001558

regulation of cell growth

PMID:12893776[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0001745

compound eye morphogenesis

PMID:15843412[2]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0003677

DNA binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

complete

GO:0003690

double-stranded DNA binding

GO_REF:0000033

PANTHER:PTHR11829_AN0

F

Missing: evidence

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

F

complete

GO:0003700

sequence-specific DNA binding transcription factor activity

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0003705

sequence-specific enhancer binding RNA polymerase II transcription factor activity

GO_REF:0000033

PANTHER:PTHR11829_AN0

F

Missing: evidence

GO:0005515

protein binding

PMID:16054033[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VS24

F

complete

GO:0005634

nucleus

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0539

C

complete

GO:0005634

nucleus

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0191

C

complete

GO:0005634

nucleus

PMID:12893776[1]

IDA: Inferred from Direct Assay

C

complete

GO:0005667

transcription factor complex

GO_REF:0000033

PANTHER:PTHR11829_AN0

C

Missing: evidence

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

complete

GO:0005737

cytoplasm

PMID:12893776[1]

IDA: Inferred from Direct Assay

C

complete

GO:0005737

cytoplasm

PMID:16564014[5]

IDA: Inferred from Direct Assay

C

complete

GO:0005829

cytosol

GO_REF:0000033

PANTHER:PTHR11829_AN111

C

Missing: evidence

GO:0005829

cytosol

Reactome:REACT_6263

TAS: Traceable Author Statement

C

complete

GO:0005977

glycogen metabolic process

PMID:17055976[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006351

transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0804

P

complete

GO:0006351

transcription, DNA-dependent

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

P

complete

GO:0006355

regulation of transcription, DNA-dependent

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0805

P

complete

GO:0006355

regulation of transcription, DNA-dependent

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006974

response to DNA damage stimulus

PMID:19543366[7]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0007049

cell cycle

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

complete

GO:0007275

multicellular organismal development

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0217

P

complete

GO:0007389

pattern specification process

GO_REF:0000033

PANTHER:PTHR11829_AN1

P

Missing: evidence

GO:0008134

transcription factor binding

GO_REF:0000033

PANTHER:PTHR11829_AN0

F

Missing: evidence

GO:0008285

negative regulation of cell proliferation

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008285

negative regulation of cell proliferation

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0010379

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IPI: Inferred from Physical Interaction

FB:FBgn0013984

P

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IPI: Inferred from Physical Interaction

FB:FBgn0261560

P

complete

GO:0008301

DNA bending activity

GO_REF:0000033

PANTHER:PTHR11829_AN1

F

Missing: evidence

GO:0008340

determination of adult lifespan

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008340

determination of adult lifespan

PMID:15192154[10]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009267

cellular response to starvation

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009617

response to bacterium

PMID:17055976[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0009790

embryo development

GO_REF:0000033

PANTHER:PTHR11829_AN1

P

Missing: evidence

GO:0009888

tissue development

GO_REF:0000033

PANTHER:PTHR11829_AN1

P

Missing: evidence

GO:0010259

multicellular organismal aging

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0010506

regulation of autophagy

PMID:17363962[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0016241

regulation of macroautophagy

PMID:17363962[11]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0019216

regulation of lipid metabolic process

PMID:18234213[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0019901

protein kinase binding

GO_REF:0000033

PANTHER:PTHR11829_AN111

F

Missing: evidence

GO:0030154

cell differentiation

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0221

P

complete

GO:0030308

negative regulation of cell growth

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0034599

cellular response to oxidative stress

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0040008

regulation of growth

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0341

P

complete

GO:0040008

regulation of growth

PMID:18665908[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0020238

P

complete

GO:0040015

negative regulation of multicellular organism growth

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0040027

negative regulation of vulval development

GO_REF:0000033

PANTHER:PTHR11829_AN217

P

Missing: evidence

GO:0042593

glucose homeostasis

PMID:18234213[12]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018122

F

complete

GO:0045792

negative regulation of cell size

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

GO_REF:0000033

PANTHER:PTHR11829_AN111

P

Missing: evidence

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0010379

P

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0015279

P

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0024248

P

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0026317

P

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0026379

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:12893776[1]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0051090

regulation of sequence-specific DNA binding transcription factor activity

GO_REF:0000033

PANTHER:PTHR11829_AN0

P

Missing: evidence

GO:0001077

transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding

PMID:18234213[12]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0001558

regulation of cell growth

PMID:12893776[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0001578

microtubule bundle formation

PMID:22312004[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0001745

compound eye morphogenesis

PMID:15843412[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003677

DNA binding

PMID:19651894[15]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:18177722[16]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:20888228[17]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16054033[4]

IPI: Inferred from Physical Interaction

UniProtKB:Q9VS24

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:21565616[18]

IPI: Inferred from Physical Interaction

UniProtKB:Q8I9J6

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:12893776[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:18234213[12]

IC: Inferred by Curator

GO:0001077

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:12893776[1]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:16564014[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005977

glycogen metabolic process

PMID:17055976[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006171

cAMP biosynthetic process

PMID:19651894[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006171

cAMP biosynthetic process

PMID:19651894[15]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006366

transcription from RNA polymerase II promoter

PMID:18234213[12]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:19543366[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006979

response to oxidative stress

PMID:17895391[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007049

cell cycle

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:21635778[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007520

myoblast fusion

PMID:24191061[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007525

somatic muscle development

PMID:24191061[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007623

circadian rhythm

PMID:17895391[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008285

negative regulation of cell proliferation

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IGI: Inferred from Genetic Interaction

FB:FBgn0010379

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IPI: Inferred from Physical Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:12893776[1]

IPI: Inferred from Physical Interaction

FB:FBgn0261560

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:15192154[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:25232726[22]

IGI: Inferred from Genetic Interaction

FB:FBgn0000097

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:25232726[22]

IGI: Inferred from Genetic Interaction

FB:FBgn0003118

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18177722[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009267

cellular response to starvation

PMID:18234213[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009617

response to bacterium

PMID:17055976[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0009617

response to bacterium

PMID:19237508[23]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0010259

multicellular organismal aging

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010506

regulation of autophagy

PMID:17363962[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010888

negative regulation of lipid storage

PMID:24035390[24]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0016241

regulation of macroautophagy

PMID:17363962[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0019216

regulation of lipid metabolic process

PMID:18234213[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030308

negative regulation of cell growth

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0031490

chromatin DNA binding

PMID:24244197[25]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0032925

regulation of activin receptor signaling pathway

PMID:24244197[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0034198

cellular response to amino acid starvation

PMID:18650956[26]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0034599

cellular response to oxidative stress

PMID:12908874[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0035206

regulation of hemocyte proliferation

PMID:20688956[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0036099

female germ-line stem cell maintenance

PMID:23895933[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040008

regulation of growth

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

GO:0040008

regulation of growth

PMID:18665908[13]

IGI: Inferred from Genetic Interaction

FB:FBgn0020238

P

Seeded From UniProt

complete

GO:0040015

negative regulation of multicellular organism growth

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0042593

glucose homeostasis

PMID:18234213[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:20888228[17]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0045475

locomotor rhythm

PMID:24690889[29]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:0045792

negative regulation of cell size

PMID:12844367[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045892

negative regulation of transcription, DNA-templated

PMID:24244197[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:19651894[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24244197[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:18177722[16]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:20888228[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0010379

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0015279

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0024248

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0026317

P

Seeded From UniProt

complete

GO:0046626

regulation of insulin receptor signaling pathway

PMID:12908874[3]

IGI: Inferred from Genetic Interaction

FB:FBgn0026379

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:12893776[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:15175753[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048813

dendrite morphogenesis

PMID:23977298[30]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1900078

positive regulation of cellular response to insulin stimulus

PMID:23895933[28]

IGI: Inferred from Genetic Interaction

FB:FBgn0013984

P

Seeded From UniProt

complete

GO:2000130

positive regulation of octopamine signaling pathway

PMID:24690889[29]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:2000253

positive regulation of feeding behavior

PMID:22876196[31]

IGI: Inferred from Genetic Interaction

FB:FBgn0259168

P

Seeded From UniProt

complete

GO:2000253

positive regulation of feeding behavior

PMID:22876196[31]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 Puig, O et al. (2003) Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 2006-20 PubMed GONUTS page
  2. 2.0 2.1 Goberdhan, DC et al. (2005) PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 132 2365-75 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 3.13 3.14 3.15 3.16 3.17 3.18 3.19 3.20 3.21 3.22 3.23 3.24 Jünger, MA et al. (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2 20 PubMed GONUTS page
  4. 4.0 4.1 Teleman, AA et al. (2005) Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9 271-81 PubMed GONUTS page
  5. 5.0 5.1 Betschinger, J et al. (2006) Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell 124 1241-53 PubMed GONUTS page
  6. 6.0 6.1 6.2 6.3 Dionne, MS et al. (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 16 1977-85 PubMed GONUTS page
  7. 7.0 7.1 Ravi, D et al. (2009) A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 5 e1000527 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 Kramer, JM et al. (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3 5 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Hwangbo, DS et al. (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 562-6 PubMed GONUTS page
  10. 10.0 10.1 Giannakou, ME et al. (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 361 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Juhász, G et al. (2007) Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ. 14 1181-90 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 Vihervaara, T & Puig, O (2008) dFOXO regulates transcription of a Drosophila acid lipase. J. Mol. Biol. 376 1215-23 PubMed GONUTS page
  13. 13.0 13.1 Nielsen, MD et al. (2008) 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell 7 688-99 PubMed GONUTS page
  14. Nechipurenko, IV & Broihier, HT (2012) FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. J. Cell Biol. 196 345-62 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Mattila, J et al. (2009) Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Mol. Cell. Biol. 29 5357-65 PubMed GONUTS page
  16. 16.0 16.1 16.2 Teleman, AA et al. (2008) Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab. 7 21-32 PubMed GONUTS page
  17. 17.0 17.1 17.2 Francis, VA et al. (2010) dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr. Biol. 20 1799-808 PubMed GONUTS page
  18. Wang, B et al. (2011) A hormone-dependent module regulating energy balance. Cell 145 596-606 PubMed GONUTS page
  19. 19.0 19.1 Zheng, X et al. (2007) FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 104 15899-904 PubMed GONUTS page
  20. Carreira, VP et al. (2011) Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. BMC Dev. Biol. 11 32 PubMed GONUTS page
  21. 21.0 21.1 Tixier, V et al. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proc. Natl. Acad. Sci. U.S.A. 110 18982-7 PubMed GONUTS page
  22. 22.0 22.1 Alic, N et al. (2014) Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster. PLoS Genet. 10 e1004619 PubMed GONUTS page
  23. Wagner, C et al. (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23 2045-54 PubMed GONUTS page
  24. Karpac, J et al. (2013) Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep 4 1250-61 PubMed GONUTS page
  25. 25.0 25.1 25.2 25.3 Bai, H et al. (2013) Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila. PLoS Genet. 9 e1003941 PubMed GONUTS page
  26. Kramer, JM et al. (2008) foxo is required for resistance to amino acid starvation in Drosophila. Genome 51 668-72 PubMed GONUTS page
  27. Sinenko, SA et al. (2010) Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model. Blood 116 4612-20 PubMed GONUTS page
  28. 28.0 28.1 Yang, SA et al. (2013) FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Dev. Biol. 382 124-35 PubMed GONUTS page
  29. 29.0 29.1 Metaxakis, A et al. (2014) Lowered insulin signalling ameliorates age-related sleep fragmentation in Drosophila. PLoS Biol. 12 e1001824 PubMed GONUTS page
  30. Iyer, EP et al. (2013) Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning. PLoS ONE 8 e72434 PubMed GONUTS page
  31. 31.0 31.1 Hong, SH et al. (2012) Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 8 e1002857 PubMed GONUTS page