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PMID:17055976

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Citation

Dionne, MS, Pham, LN, Shirasu-Hiza, M and Schneider, DS (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 16:1977-85

Abstract

Studies in Drosophila have taught us a great deal about how animals regulate the immediate innate immune response, but we still know little about how infections cause pathology. Here, we examine the pathogenesis associated with Mycobacterium marinum infection in the fly. M. marinum is closely related to M. tuberculosis, which causes tuberculosis in people.

Links

PubMed Online version:10.1016/j.cub.2006.08.052

Keywords

Animals; Blotting, Western; DNA Primers; Drosophila Proteins/metabolism; Drosophila melanogaster/immunology; Drosophila melanogaster/metabolism; Drosophila melanogaster/microbiology; Energy Metabolism/physiology; Forkhead Transcription Factors/metabolism; Gene Expression Regulation/physiology; Insulin/metabolism; Longevity; Microarray Analysis; Mycobacterium marinum; Proto-Oncogene Proteins c-akt/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Weight Loss/physiology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

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