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PMID:17055976
Citation |
Dionne, MS, Pham, LN, Shirasu-Hiza, M and Schneider, DS (2006) Akt and FOXO dysregulation contribute to infection-induced wasting in Drosophila. Curr. Biol. 16:1977-85 |
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Abstract |
Studies in Drosophila have taught us a great deal about how animals regulate the immediate innate immune response, but we still know little about how infections cause pathology. Here, we examine the pathogenesis associated with Mycobacterium marinum infection in the fly. M. marinum is closely related to M. tuberculosis, which causes tuberculosis in people. |
Links |
PubMed Online version:10.1016/j.cub.2006.08.052 |
Keywords |
Animals; Blotting, Western; DNA Primers; Drosophila Proteins/metabolism; Drosophila melanogaster/immunology; Drosophila melanogaster/metabolism; Drosophila melanogaster/microbiology; Energy Metabolism/physiology; Forkhead Transcription Factors/metabolism; Gene Expression Regulation/physiology; Insulin/metabolism; Longevity; Microarray Analysis; Mycobacterium marinum; Proto-Oncogene Proteins c-akt/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Weight Loss/physiology |
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Significance
Annotations
Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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