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PMID:12844367
| Citation |
Kramer, JM, Davidge, JT, Lockyer, JM and Staveley, BE (2003) Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3:5 |
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| Abstract |
Components of the insulin signaling pathway are important regulators of growth. The FOXO (forkhead box, sub-group "O") transcription factors regulate cellular processes under conditions of low levels of insulin signaling. Studies in mammalian cell culture show that activation of FOXO transcription factors causes cell death or cell cycle arrest. The Caenorhabditis elegans homologue of FOXO, Daf-16, is required for the formation of dauer larvae in response to nutritional stress. In addition, FOXO factors have been implicated in stress resistance and longevity. |
| Links |
PubMed PMC183841 Online version:10.1186/1471-213X-3-5 |
| Keywords |
Amino Acid Sequence; Animals; Apoptosis/physiology; Caenorhabditis elegans Proteins; Cell Cycle/physiology; Cell Division/genetics; Cell Division/physiology; Cell Line; Cell Size; Conserved Sequence/genetics; Conserved Sequence/physiology; Databases, Genetic; Drosophila Proteins/biosynthesis; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Drosophila melanogaster/embryology; Drosophila melanogaster/enzymology; Drosophila melanogaster/genetics; Drosophila melanogaster/growth & development; Feedback, Physiological/genetics; Feedback, Physiological/physiology; Feeding Behavior/physiology; Forkhead Transcription Factors; Humans; Insulin/physiology; Larva/genetics; Larva/growth & development; Larva/physiology; Mice; Molecular Sequence Data; Phenotype; Phosphatidylinositol 3-Kinases/antagonists & inhibitors; Phosphatidylinositol 3-Kinases/physiology; Protein-Serine-Threonine Kinases; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-akt; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction/physiology; Starvation/genetics; Transcription Factors/biosynthesis; Transcription Factors/genetics; Transcription Factors/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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