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PMID:19237508

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Citation

Wagner, C, Isermann, K and Roeder, T (2009) Infection induces a survival program and local remodeling in the airway epithelium of the fly. FASEB J. 23:2045-54

Abstract

Although the prevalence of inflammatory airway diseases is steadily growing, our knowledge regarding the underlying molecular and cellular mechanisms is fragmentary. The striking simplicity of the fruit fly's airway epithelium, which is composed of epithelial cells only, justifies its use as a model to study general features and response characteristics of airway epithelia in general. Infection with the gram-negative pathogen Erwinia carotovora induces an immune response in all epithelial cells via activation of the immune deficiency (IMD) pathway, but the transcriptional profile differs significantly from that observed after ectopic activation of this signaling pathway. After strong infections, genes controlling central aspects of tracheal development are reactivated, a response that is not seen after ectopic IMD pathway activation. Presumably to counteract infection-induced cell death-promoting signals, a survival response is launched, characterized by the concurrent expression and activation of the longevity genes dfoxo and dthor. Regions of the airways featuring the strongest immune reactions show substantial remodeling, which is characterized by a significant thickening of the epithelial cells. In conclusion, features related to those observed in inflammatory diseases of the human airways are apparently part of the normal response repertoire of airway epithelia to infection.

Links

PubMed Online version:10.1096/fj.08-114223

Keywords

Animals; Cell Survival/immunology; Drosophila/immunology; Drosophila/microbiology; Epithelial Cells; Epithelium/immunology; Epithelium/microbiology; Epithelium/pathology; Infection/immunology; Infection/pathology; Pectobacterium carotovorum; Respiratory System/immunology; Respiratory System/microbiology; Respiratory System/pathology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:DEFI

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DROS

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:MTK

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PGPLF

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:NFKB1

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:PGPLA

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:4EBP

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FOXO

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DMYC

involved_in

GO:0009617: response to bacterium

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

Notes

See also

References

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