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PMID:12908874
| Citation |
Jünger, MA, Rintelen, F, Stocker, H, Wasserman, JD, Végh, M, Radimerski, T, Greenberg, ME and Hafen, E (2003) The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2:20 |
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| Abstract |
Forkhead transcription factors belonging to the FOXO subfamily are negatively regulated by protein kinase B (PKB) in response to signaling by insulin and insulin-like growth factor in Caenorhabditis elegans and mammals. In Drosophila, the insulin-signaling pathway regulates the size of cells, organs, and the entire body in response to nutrient availability, by controlling both cell size and cell number. In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog. |
| Links |
PubMed PMC333403 Online version:10.1186/1475-4924-2-20 |
| Keywords |
Amino Acid Sequence/genetics; Animals; Caenorhabditis elegans Proteins/genetics; Cell Death/genetics; Cell Death/physiology; Cells, Cultured; Drosophila/cytology; Drosophila/embryology; Drosophila/enzymology; Drosophila/genetics; Drosophila Proteins/biosynthesis; Drosophila Proteins/deficiency; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Energy Intake/genetics; Energy Intake/physiology; Female; Forkhead Transcription Factors; Genes, Insect/physiology; Insulin/physiology; Intracellular Signaling Peptides and Proteins/deficiency; Male; Molecular Sequence Data; Mutation/physiology; Nuclear Proteins/genetics; Organ Size/genetics; Organ Size/physiology; Oxidative Stress/physiology; Phenotype; Protein Biosynthesis/physiology; Protein-Serine-Threonine Kinases/deficiency; Sequence Homology, Amino Acid; Signal Transduction/physiology; Transcription Factors/biosynthesis; Transcription Factors/deficiency; Transcription Factors/genetics; Transcription Factors/physiology; Transcription, Genetic/physiology; Up-Regulation/genetics |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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