DROME:AUB

Species (Taxon ID)	Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s)	aub
Protein Name(s)	Protein aubergine (ECO:0000312 with EMBL:AGA18944.1) Protein sting (ECO:0000312 with EMBL:AAD38655.1)
External Links
UniProt	O76922
EMBL	X94613 KC116210 KC116211 KC116212 KC116213 KC116214 KC116215 KC116216 KC116217 AE014134 AE014134 AF145680 JX656893 JX656894 JX656895
RefSeq	NP_001097144.1 NP_476734.1
UniGene	Dm.3112
PDB	3NTH 3NTI
PDBsum	3NTH 3NTI
ProteinModelPortal	O76922
SMR	O76922
IntAct	O76922
MINT	MINT-1628903
STRING	7227.FBpp0079754
PRIDE	O76922
EnsemblMetazoa	FBtr0080165
GeneID	34524
KEGG	dme:Dmel_CG6137
UCSC	CG6137-RA
CTD	34524
FlyBase	FBgn0000146
GeneTree	ENSGT00760000119148
InParanoid	O76922
KO	K02156
OMA	YANMCEN
OrthoDB	EOG712TVQ
PhylomeDB	O76922
EvolutionaryTrace	O76922
GenomeRNAi	34524
NextBio	788894
Proteomes	UP000000803
ExpressionAtlas	O76922
GO	GO:0071013 GO:0005737 GO:0005875 GO:0043186 GO:0071011 GO:0034584 GO:0003723 GO:0006342 GO:0050829 GO:0046843 GO:0030717 GO:0046594 GO:0007076 GO:0000398 GO:0010529 GO:0001556 GO:0048477 GO:0007279 GO:0007318 GO:0045089 GO:0060213 GO:0046012 GO:0046011 GO:0007317 GO:0006446 GO:0016246 GO:0035282 GO:0030423
Gene3D	3.30.420.10
InterPro	IPR003100 IPR003165 IPR012337
Pfam	PF02170 PF02171
SMART	SM00949 SM00950
SUPFAM	SSF101690 SSF53098
PROSITE	PS50821 PS50822

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:12154120^[1]	ECO:0000315			P	Figure 3	complete CACAO 7605
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:12154120^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:30260314^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22902557^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007076	mitotic chromosome condensation	PMID:21185189^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:20980675^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035282	segmentation	PMID:20937269^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0002962	P	Seeded From UniProt	complete
involved_in	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	PMID:20953170^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:19520911^[8]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:19520911^[8]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:18590813^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:18590813^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0283442	P	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:18590813^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003891	P	Seeded From UniProt	complete
part_of	GO:0071013	catalytic step 2 spliceosome	PMID:18981222^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000398	mRNA splicing, via spliceosome	PMID:18981222^[10]	ECO:0000305	curator inference used in manual assertion	GO:0071011,GO:0071013	P	Seeded From UniProt	complete
part_of	GO:0071011	precatalytic spliceosome	PMID:18981222^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0010529	negative regulation of transposition	PMID:17603126^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17346786^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:17346786^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0046843	dorsal appendage formation	PMID:17199040^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007318	pole plasm protein localization	PMID:17199040^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:16530043^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016246	RNA interference	PMID:15035985^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007317	regulation of pole plasm oskar mRNA localization	PMID:15035984^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:14752161^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046012	positive regulation of oskar mRNA translation	PMID:12655640^[18]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:12154120^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0001556	oocyte maturation	PMID:12154120^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007279	pole cell formation	PMID:11526087^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	FB:FBgn0003015	P	Seeded From UniProt	complete
involved_in	GO:0006446	regulation of translational initiation	PMID:11526087^[19]	ECO:0000250	sequence similarity evidence used in manual assertion	protein_id:AAC24323.1	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11526087^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:11526087^[19]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0046843	dorsal appendage formation	PMID:1783295^[20]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:1783295^[20]	ECO:0007001	high throughput mutant phenotypic evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034584	piRNA binding	PMID:26295961^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26295961^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:26295961^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0043186	P granule	PMID:25908854^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	PMID:25908854^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003165 InterPro:IPR036397	F	Seeded From UniProt	complete
involved_in	GO:0016246	RNA interference	PMID:15102435^[23] PMID:12493247^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046594	maintenance of pole plasm mRNA location	PMID:11700288^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030717	oocyte karyosome formation	PMID:11700288^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046011	regulation of oskar mRNA translation	PMID:11700288^[25] PMID:10449356^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046012	positive regulation of oskar mRNA translation	PMID:11131516^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	PMID:10449356^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0896	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kennerdell, JR et al. (2002) RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16 1884-9 PubMed GONUTS page
↑ Kistler, KE et al. (2018) Phase transitioned nuclear Oskar promotes cell division of primordial germ cells. Elife 7 PubMed GONUTS page
↑ Olivieri, D et al. (2012) The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 47 954-69 PubMed GONUTS page
↑ Pek, JW & Kai, T (2011) A role for vasa in regulating mitotic chromosome condensation in Drosophila. Curr. Biol. 21 39-44 PubMed GONUTS page
↑ Nagao, A et al. (2010) Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA 16 2503-15 PubMed GONUTS page
↑ Becalska, AN et al. (2011) Aubergine is a component of a nanos mRNA localization complex. Dev. Biol. 349 46-52 PubMed GONUTS page
↑ Rouget, C et al. (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467 1128-32 PubMed GONUTS page
↑ ^8.0 ^8.1 Cronin, SJ et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325 340-3 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
↑ Simmons, MJ et al. (2007) Cytotype regulation by telomeric P elements in Drosophila melanogaster: evidence for involvement of an RNA interference gene. Genetics 176 1945-55 PubMed GONUTS page
↑ ^12.0 ^12.1 Brennecke, J et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128 1089-103 PubMed GONUTS page
↑ ^13.0 ^13.1 Klattenhoff, C et al. (2007) Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12 45-55 PubMed GONUTS page
↑ Grimaud, C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124 957-71 PubMed GONUTS page
↑ Tomari, Y et al. (2004) RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116 831-41 PubMed GONUTS page
↑ Cook, HA et al. (2004) The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell 116 817-29 PubMed GONUTS page
↑ Pal-Bhadra, M et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303 669-72 PubMed GONUTS page
↑ Leatherman, JL & Jongens, TA (2003) Transcriptional silencing and translational control: key features of early germline development. Bioessays 25 326-35 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Harris, AN & Macdonald, PM (2001) Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128 2823-32 PubMed GONUTS page
↑ ^20.0 ^20.1 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Webster, A et al. (2015) Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol. Cell 59 564-75 PubMed GONUTS page
↑ ^22.0 ^22.1 Bozzetti, MP et al. (2015) The Drosophila fragile X mental retardation protein participates in the piRNA pathway. J. Cell. Sci. 128 2070-84 PubMed GONUTS page
↑ Lavorgna, G et al. (2004) In search of antisense. Trends Biochem. Sci. 29 88-94 PubMed GONUTS page
↑ Cerutti, H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet. 19 39-46 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page
↑ ^26.0 ^26.1 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
↑ Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page

[PMID:12154120-1] 1.0 ^1.1 ^1.2 ^1.3 Kennerdell, JR et al. (2002) RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16 1884-9 PubMed GONUTS page

[PMID:30260314-2] Kistler, KE et al. (2018) Phase transitioned nuclear Oskar promotes cell division of primordial germ cells. Elife 7 PubMed GONUTS page

[PMID:22902557-3] Olivieri, D et al. (2012) The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 47 954-69 PubMed GONUTS page

[PMID:21185189-4] Pek, JW & Kai, T (2011) A role for vasa in regulating mitotic chromosome condensation in Drosophila. Curr. Biol. 21 39-44 PubMed GONUTS page

[PMID:20980675-5] Nagao, A et al. (2010) Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA 16 2503-15 PubMed GONUTS page

[PMID:20937269-6] Becalska, AN et al. (2011) Aubergine is a component of a nanos mRNA localization complex. Dev. Biol. 349 46-52 PubMed GONUTS page

[PMID:20953170-7] Rouget, C et al. (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467 1128-32 PubMed GONUTS page

[PMID:19520911-8] 8.0 ^8.1 Cronin, SJ et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325 340-3 PubMed GONUTS page

[PMID:18590813-9] 9.0 ^9.1 ^9.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page

[PMID:18981222-10] 10.0 ^10.1 ^10.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page

[PMID:17603126-11] Simmons, MJ et al. (2007) Cytotype regulation by telomeric P elements in Drosophila melanogaster: evidence for involvement of an RNA interference gene. Genetics 176 1945-55 PubMed GONUTS page

[PMID:17346786-12] 12.0 ^12.1 Brennecke, J et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128 1089-103 PubMed GONUTS page

[PMID:17199040-13] 13.0 ^13.1 Klattenhoff, C et al. (2007) Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12 45-55 PubMed GONUTS page

[PMID:16530043-14] Grimaud, C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124 957-71 PubMed GONUTS page

[PMID:15035985-15] Tomari, Y et al. (2004) RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116 831-41 PubMed GONUTS page

[PMID:15035984-16] Cook, HA et al. (2004) The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell 116 817-29 PubMed GONUTS page

[PMID:14752161-17] Pal-Bhadra, M et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303 669-72 PubMed GONUTS page

[PMID:12655640-18] Leatherman, JL & Jongens, TA (2003) Transcriptional silencing and translational control: key features of early germline development. Bioessays 25 326-35 PubMed GONUTS page

[PMID:11526087-19] 19.0 ^19.1 ^19.2 ^19.3 Harris, AN & Macdonald, PM (2001) Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128 2823-32 PubMed GONUTS page

[PMID:1783295-20] 20.0 ^20.1 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page

[PMID:26295961-21] 21.0 ^21.1 ^21.2 Webster, A et al. (2015) Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol. Cell 59 564-75 PubMed GONUTS page

[PMID:25908854-22] 22.0 ^22.1 Bozzetti, MP et al. (2015) The Drosophila fragile X mental retardation protein participates in the piRNA pathway. J. Cell. Sci. 128 2070-84 PubMed GONUTS page

[PMID:15102435-23] Lavorgna, G et al. (2004) In search of antisense. Trends Biochem. Sci. 29 88-94 PubMed GONUTS page

[PMID:12493247-24] Cerutti, H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet. 19 39-46 PubMed GONUTS page

[PMID:11700288-25] 25.0 ^25.1 ^25.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page

[PMID:10449356-26] 26.0 ^26.1 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page

[PMID:11131516-27] Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page

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DROME:AUB

Contents

Annotations

Notes

References

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