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DROME:AUB

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) aub
Protein Name(s) Protein aubergine (ECO:0000312 with EMBL:AGA18944.1)

Protein sting (ECO:0000312 with EMBL:AAD38655.1)

External Links
UniProt O76922
EMBL X94613
KC116210
KC116211
KC116212
KC116213
KC116214
KC116215
KC116216
KC116217
AE014134
AE014134
AF145680
JX656893
JX656894
JX656895
RefSeq NP_001097144.1
NP_476734.1
UniGene Dm.3112
PDB 3NTH
3NTI
PDBsum 3NTH
3NTI
ProteinModelPortal O76922
SMR O76922
IntAct O76922
MINT MINT-1628903
STRING 7227.FBpp0079754
PRIDE O76922
EnsemblMetazoa FBtr0080165
GeneID 34524
KEGG dme:Dmel_CG6137
UCSC CG6137-RA
CTD 34524
FlyBase FBgn0000146
GeneTree ENSGT00760000119148
InParanoid O76922
KO K02156
OMA YANMCEN
OrthoDB EOG712TVQ
PhylomeDB O76922
EvolutionaryTrace O76922
GenomeRNAi 34524
NextBio 788894
Proteomes UP000000803
ExpressionAtlas O76922
GO GO:0071013
GO:0005737
GO:0005875
GO:0043186
GO:0071011
GO:0034584
GO:0003723
GO:0006342
GO:0050829
GO:0046843
GO:0030717
GO:0046594
GO:0007076
GO:0000398
GO:0010529
GO:0001556
GO:0048477
GO:0007279
GO:0007318
GO:0045089
GO:0060213
GO:0046012
GO:0046011
GO:0007317
GO:0006446
GO:0016246
GO:0035282
GO:0030423
Gene3D 3.30.420.10
InterPro IPR003100
IPR003165
IPR012337
Pfam PF02170
PF02171
SMART SM00949
SM00950
SUPFAM SSF101690
SSF53098
PROSITE PS50821
PS50822

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3

complete
CACAO 7605

GO:0000398

mRNA splicing, via spliceosome

PMID:18981222[2]

IC: Inferred by Curator

GO:0071011
GO:0071013

P

Seeded From UniProt

complete

GO:0001556

oocyte maturation

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003165
InterPro:IPR012337

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:17346786[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19959991[4]

IPI: Inferred from Physical Interaction

UniProtKB:P25823

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11526087[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:17346786[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:22902557[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:18433294[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:14752161[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:16530043[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

GO:0006446

regulation of translational initiation

PMID:11526087[5]

ISS: Inferred from Sequence or Structural Similarity

protein_id:AAC24323.1

P

Seeded From UniProt

complete

GO:0007076

mitotic chromosome condensation

PMID:21185189[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:11526087[5]

IGI: Inferred from Genetic Interaction

FB:FBgn0003015

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:18590813[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0003891

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:18590813[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0283442

P

Seeded From UniProt

complete

GO:0007317

regulation of pole plasm oskar mRNA localization

PMID:15035984[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007318

pole plasm protein localization

PMID:17199040[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010529

negative regulation of transposition

PMID:17603126[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:12493247[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:15035985[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:15102435[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030717

karyosome formation

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031047

gene silencing by RNA

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

GO:0034584

piRNA binding

PMID:20980675[19]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035282

segmentation

PMID:20937269[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0002962

P

Seeded From UniProt

complete

GO:0043186

P granule

PMID:11526087[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043186

P granule

PMID:18590813[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045089

positive regulation of innate immune response

PMID:19520911[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046011

regulation of oskar mRNA translation

PMID:10449356[22]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046011

regulation of oskar mRNA translation

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046012

positive regulation of oskar mRNA translation

PMID:11131516[23]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046012

positive regulation of oskar mRNA translation

PMID:12655640[24]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046594

maintenance of pole plasm mRNA location

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:17199040[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:1783295[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:10449356[22]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:1783295[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:19520911[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

PMID:20953170[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071011

precatalytic spliceosome

PMID:18981222[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071013

catalytic step 2 spliceosome

PMID:18981222[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Kennerdell, JR et al. (2002) RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16 1884-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
  3. 3.0 3.1 Brennecke, J et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128 1089-103 PubMed GONUTS page
  4. Nishida, KM et al. (2009) Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J. 28 3820-31 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Harris, AN & Macdonald, PM (2001) Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128 2823-32 PubMed GONUTS page
  6. Olivieri, D et al. (2012) The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 47 954-69 PubMed GONUTS page
  7. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  8. Pal-Bhadra, M et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303 669-72 PubMed GONUTS page
  9. Grimaud, C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124 957-71 PubMed GONUTS page
  10. Pek, JW & Kai, T (2011) A role for vasa in regulating mitotic chromosome condensation in Drosophila. Curr. Biol. 21 39-44 PubMed GONUTS page
  11. 11.0 11.1 11.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
  12. Cook, HA et al. (2004) The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell 116 817-29 PubMed GONUTS page
  13. 13.0 13.1 Klattenhoff, C et al. (2007) Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12 45-55 PubMed GONUTS page
  14. Simmons, MJ et al. (2007) Cytotype regulation by telomeric P elements in Drosophila melanogaster: evidence for involvement of an RNA interference gene. Genetics 176 1945-55 PubMed GONUTS page
  15. Cerutti, H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet. 19 39-46 PubMed GONUTS page
  16. Tomari, Y et al. (2004) RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116 831-41 PubMed GONUTS page
  17. Lavorgna, G et al. (2004) In search of antisense. Trends Biochem. Sci. 29 88-94 PubMed GONUTS page
  18. 18.0 18.1 18.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page
  19. Nagao, A et al. (2010) Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA 16 2503-15 PubMed GONUTS page
  20. Becalska, AN et al. (2011) Aubergine is a component of a nanos mRNA localization complex. Dev. Biol. 349 46-52 PubMed GONUTS page
  21. 21.0 21.1 Cronin, SJ et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325 340-3 PubMed GONUTS page
  22. 22.0 22.1 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
  23. Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page
  24. Leatherman, JL & Jongens, TA (2003) Transcriptional silencing and translational control: key features of early germline development. Bioessays 25 326-35 PubMed GONUTS page
  25. 25.0 25.1 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
  26. Rouget, C et al. (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467 1128-32 PubMed GONUTS page