It is now the 1st OPEN Period for CACAO Fall 2017! It will end on Sunday September 24, 2017 at 11:59 pm CDT
This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:AUB

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) aub
Protein Name(s) Protein aubergine (ECO:0000312 with EMBL:AGA18944.1)

Protein sting (ECO:0000312 with EMBL:AAD38655.1)

External Links
UniProt O76922
EMBL X94613
KC116210
KC116211
KC116212
KC116213
KC116214
KC116215
KC116216
KC116217
AE014134
AE014134
AF145680
JX656893
JX656894
JX656895
RefSeq NP_001097144.1
NP_476734.1
UniGene Dm.3112
PDB 3NTH
3NTI
PDBsum 3NTH
3NTI
ProteinModelPortal O76922
SMR O76922
IntAct O76922
MINT MINT-1628903
STRING 7227.FBpp0079754
PRIDE O76922
EnsemblMetazoa FBtr0080165
GeneID 34524
KEGG dme:Dmel_CG6137
UCSC CG6137-RA
CTD 34524
FlyBase FBgn0000146
GeneTree ENSGT00760000119148
InParanoid O76922
KO K02156
OMA YANMCEN
OrthoDB EOG712TVQ
PhylomeDB O76922
EvolutionaryTrace O76922
GenomeRNAi 34524
NextBio 788894
Proteomes UP000000803
ExpressionAtlas O76922
GO GO:0071013
GO:0005737
GO:0005875
GO:0043186
GO:0071011
GO:0034584
GO:0003723
GO:0006342
GO:0050829
GO:0046843
GO:0030717
GO:0046594
GO:0007076
GO:0000398
GO:0010529
GO:0001556
GO:0048477
GO:0007279
GO:0007318
GO:0045089
GO:0060213
GO:0046012
GO:0046011
GO:0007317
GO:0006446
GO:0016246
GO:0035282
GO:0030423
Gene3D 3.30.420.10
InterPro IPR003100
IPR003165
IPR012337
Pfam PF02170
PF02171
SMART SM00949
SM00950
SUPFAM SSF101690
SSF53098
PROSITE PS50821
PS50822

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Figure 3

complete
CACAO 7605

GO:0000398

mRNA splicing, via spliceosome

PMID:18981222[2]

IC: Inferred by Curator

GO:0071011
GO:0071013

P

Seeded From UniProt

complete

GO:0001556

oocyte maturation

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003165
InterPro:IPR012337

F

Seeded From UniProt

complete

GO:0003723

RNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

GO:0003723

RNA binding

PMID:17346786[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19959991[4]

IPI: Inferred from Physical Interaction

UniProtKB:P25823

F

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11526087[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:17346786[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:22902557[6]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005875

microtubule associated complex

PMID:18433294[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:14752161[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006342

chromatin silencing

PMID:16530043[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0006417

regulation of translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0810

P

Seeded From UniProt

complete

GO:0006446

regulation of translational initiation

PMID:11526087[5]

ISS: Inferred from Sequence or Structural Similarity

protein_id:AAC24323.1

P

Seeded From UniProt

complete

GO:0007076

mitotic chromosome condensation

PMID:21185189[10]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:11526087[5]

IGI: Inferred from Genetic Interaction

FB:FBgn0003015

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:18590813[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0003891

P

Seeded From UniProt

complete

GO:0007279

pole cell formation

PMID:18590813[11]

IGI: Inferred from Genetic Interaction

FB:FBgn0283442

P

Seeded From UniProt

complete

GO:0007317

regulation of pole plasm oskar mRNA localization

PMID:15035984[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007318

pole plasm protein localization

PMID:17199040[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0010529

negative regulation of transposition

PMID:17603126[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:12493247[15]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:15035985[16]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016246

RNA interference

PMID:15102435[17]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030423

targeting of mRNA for destruction involved in RNA interference

PMID:12154120[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0030717

karyosome formation

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0031047

gene silencing by RNA

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

GO:0034584

piRNA binding

PMID:20980675[19]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0035282

segmentation

PMID:20937269[20]

IGI: Inferred from Genetic Interaction

FB:FBgn0002962

P

Seeded From UniProt

complete

GO:0043186

P granule

PMID:11526087[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0043186

P granule

PMID:18590813[11]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045089

positive regulation of innate immune response

PMID:19520911[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046011

regulation of oskar mRNA translation

PMID:10449356[22]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046011

regulation of oskar mRNA translation

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046012

positive regulation of oskar mRNA translation

PMID:11131516[23]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046012

positive regulation of oskar mRNA translation

PMID:12655640[24]

NAS: Non-traceable Author Statement

P

Seeded From UniProt

complete

GO:0046594

maintenance of pole plasm mRNA location

PMID:11700288[18]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:17199040[13]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0046843

dorsal appendage formation

PMID:1783295[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0896

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:10449356[22]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:1783295[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:19520911[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0060213

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

PMID:20953170[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0071011

precatalytic spliceosome

PMID:18981222[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0071013

catalytic step 2 spliceosome

PMID:18981222[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Kennerdell, JR et al. (2002) RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16 1884-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 Herold, N et al. (2009) Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol. Cell. Biol. 29 281-301 PubMed GONUTS page
  3. 3.0 3.1 Brennecke, J et al. (2007) Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128 1089-103 PubMed GONUTS page
  4. Nishida, KM et al. (2009) Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J. 28 3820-31 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 Harris, AN & Macdonald, PM (2001) Aubergine encodes a Drosophila polar granule component required for pole cell formation and related to eIF2C. Development 128 2823-32 PubMed GONUTS page
  6. Olivieri, D et al. (2012) The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol. Cell 47 954-69 PubMed GONUTS page
  7. Hughes, JR et al. (2008) A microtubule interactome: complexes with roles in cell cycle and mitosis. PLoS Biol. 6 e98 PubMed GONUTS page
  8. Pal-Bhadra, M et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303 669-72 PubMed GONUTS page
  9. Grimaud, C et al. (2006) RNAi components are required for nuclear clustering of Polycomb group response elements. Cell 124 957-71 PubMed GONUTS page
  10. Pek, JW & Kai, T (2011) A role for vasa in regulating mitotic chromosome condensation in Drosophila. Curr. Biol. 21 39-44 PubMed GONUTS page
  11. 11.0 11.1 11.2 Thomson, T et al. () Isolation of new polar granule components in Drosophila reveals P body and ER associated proteins. Mech. Dev. 125 865-73 PubMed GONUTS page
  12. Cook, HA et al. (2004) The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. Cell 116 817-29 PubMed GONUTS page
  13. 13.0 13.1 Klattenhoff, C et al. (2007) Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev. Cell 12 45-55 PubMed GONUTS page
  14. Simmons, MJ et al. (2007) Cytotype regulation by telomeric P elements in Drosophila melanogaster: evidence for involvement of an RNA interference gene. Genetics 176 1945-55 PubMed GONUTS page
  15. Cerutti, H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet. 19 39-46 PubMed GONUTS page
  16. Tomari, Y et al. (2004) RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116 831-41 PubMed GONUTS page
  17. Lavorgna, G et al. (2004) In search of antisense. Trends Biochem. Sci. 29 88-94 PubMed GONUTS page
  18. 18.0 18.1 18.2 Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page
  19. Nagao, A et al. (2010) Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis. RNA 16 2503-15 PubMed GONUTS page
  20. Becalska, AN et al. (2011) Aubergine is a component of a nanos mRNA localization complex. Dev. Biol. 349 46-52 PubMed GONUTS page
  21. 21.0 21.1 Cronin, SJ et al. (2009) Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science 325 340-3 PubMed GONUTS page
  22. 22.0 22.1 van Eeden, F & St Johnston, D (1999) The polarisation of the anterior-posterior and dorsal-ventral axes during Drosophila oogenesis. Curr. Opin. Genet. Dev. 9 396-404 PubMed GONUTS page
  23. Mahowald, AP (2001) Assembly of the Drosophila germ plasm. Int. Rev. Cytol. 203 187-213 PubMed GONUTS page
  24. Leatherman, JL & Jongens, TA (2003) Transcriptional silencing and translational control: key features of early germline development. Bioessays 25 326-35 PubMed GONUTS page
  25. 25.0 25.1 Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
  26. Rouget, C et al. (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467 1128-32 PubMed GONUTS page