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PMID:12493247
| Citation |
Cerutti, H (2003) RNA interference: traveling in the cell and gaining functions? Trends Genet. 19:39-46 |
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| Abstract |
Double-stranded RNA can induce the degradation of homologous RNAs in organisms as diverse as protozoa, animals, plants and fungi, resulting in post-transcriptional gene silencing. But in some species, RNA-mediated processes can also lead to translational repression, DNA methylation, heterochromatin formation or DNA elimination. In some situations, amplification of the 'trigger' double-stranded RNA seems to be required for efficient silencing. These findings imply that RNA-mediated mechanisms can control gene expression at both the transcriptional and the post-transcriptional level, and that they can operate in the nuclear and the cytoplasmic compartments. |
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| Keywords |
Animals; Drosophila/genetics; Gene Silencing; Humans; MicroRNAs/metabolism; RNA Interference |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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