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Category:GO:0016246 ! RNA interference

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DAG for GO:0016246id: GO:0016246

name: RNA interference
namespace: biological_process
def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]
comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah]
synonym: "RNAi" EXACT []
xref: Wikipedia:RNA_interference
is_a: GO:0035194 ! post-transcriptional gene silencing by RNA

AmiGO <GOterm>GO:0016246</GOterm>
Gene Ontology Home

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Usage Notes

This is not an appropriate term for most prokaryotic small RNAs that negatively regulate translation[1] because it is a descendant of GO:0016458_!_gene_silencing, which is defined as involving long-term inactivation of gene expression.


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  1. Gottesman, S (2004) The small RNA regulators of Escherichia coli: roles and mechanisms*. Annu. Rev. Microbiol. 58 303-28 PubMed GONUTS page