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Category:Team The Dynamic Protein Duo

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StatusPageUserDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
requireschangesECOLI:CLPXMassi003, Team The Dynamic Protein Duo2012-04-13 12:14:48 CDTGO:0009408 response to heat (P)PMID:21317324ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1A depletion of clpX surpresses temperature-sensitive filamentation in cells causing them to be shorter.

challenge
requireschangesECOLI:CLPPMassi003, Team The Dynamic Protein Duo2012-04-13 11:56:06 CDTGO:0009408 response to heat (P)PMID:21317324ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 1A deletion of clpP suppresses temperature-sensitive filamentation cells causing the cells to become elongated.

challenge
requireschangesECOLI:NMPCMassi003, Team The Dynamic Protein Duo2012-04-13 11:11:07 CDTGO:0015288 porin activity (F)PMID:21398480ECO:0000314 direct assay evidence used in manual assertion

Fig 3 E.coli cells expressing nmpC were more reistant to heat and had a higher survival rate.

challenge
requireschangesBACSU:CGEAMassi003, Team The Dynamic Protein Duo2012-04-13 10:57:34 CDTGO:0031160 spore wall (C)PMID:21665972ECO:0000314 direct assay evidence used in manual assertion

Fig 2c CgeA is involved in the formation of the spore crust

challenge
requireschangesBACSU:COTZMassi003, Team The Dynamic Protein Duo2012-04-13 10:53:09 CDTGO:0031160 spore wall (C)PMID:21665972ECO:0000314 direct assay evidence used in manual assertion

Fig 2b CotZ is involved in the formation of the spore crust

challenge
requireschangesECOLI:MREBMassi003, Team The Dynamic Protein Duo2012-03-14 23:50:39 CDTGO:0043164 Gram-negative-bacterium-type cell wall biogenesis (P)PMID:19346310ECO:0000316 genetic interaction evidence used in manual assertion

Table 1 Strain 2 MreB can tether peptidoglycan synthesis via a PBP2 pathway independently of FtsZ, producing a rod-shaped cell

challenge
requireschangesECOLI:FTSZMassi003, Team The Dynamic Protein Duo2012-03-14 23:22:34 CDTGO:0043164 Gram-negative-bacterium-type cell wall biogenesis (P)PMID:19346310ECO:0000316 genetic interaction evidence used in manual assertion

Table 1 strain 3 In the absence of MreB, FtsZ can tether and direct a generalized and evenly dispersed peptidoglycan, via a PBP2 pathway, producing a spherical-shaped cell

challenge
requireschangesMOUSE:UCP2Wedde001, Team The Dynamic Protein Duo2012-02-24 11:17:16 CSTGO:0005743 mitochondrial inner membrane (C)PMID:22348126ECO:0000314 direct assay evidence used in manual assertion

Figure 2 overexpression of UCP2 in the brain results in less tissue damage after focal ischemia

challenge
unacceptableMOUSE:IL6Wedde001, Team The Dynamic Protein Duo2012-02-24 10:17:19 CSTGO:0042493 response to drug (P)PMID:22047130ECO:0000314 direct assay evidence used in manual assertion

Figure 2C treatment with diazoxide decreases release of IL-6 in a dose dependent manner

challenge
requireschangesHUMAN:HIF1AMassi003, Team The Dynamic Protein Duo2012-02-20 11:51:59 CSTGO:0001666 response to hypoxia (P)PMID:22292025ECO:0000314 direct assay evidence used in manual assertion

Fig 1A as hypoxia occurs, levels of HIF-1alpha increase

challenge
requireschangesHUMAN:UCP2Massi003, Team The Dynamic Protein Duo2012-02-20 11:48:41 CSTGO:0006915 apoptotic process (P)PMID:22292025ECO:0000314 direct assay evidence used in manual assertion

Fig 3A overexpression of UCP2 under hypoxic conditions decreases levels of apoptosis

challenge
acceptableHUMAN:UCP2Massi003, Team The Dynamic Protein Duo2012-02-20 11:45:54 CSTGO:0001666 response to hypoxia (P)PMID:22292025ECO:0000314 direct assay evidence used in manual assertion

Fig 1B - UCP2 levels increase as levels of hypoxia increase

challenge
requireschangesECOLI:DACAWedde001, Team The Dynamic Protein Duo2012-02-10 11:09:46 CSTGO:0008658 penicillin binding (F)PMID:10692378ECO:0000315 mutant phenotype evidence used in manual assertion

Fig 4 and Table 2 Lack of PBP 5 produces irregular shape and size in cells

challenge
unacceptableECOLI:MREBWedde001, Team The Dynamic Protein Duo2012-02-10 10:23:00 CSTGO:0005200 structural constituent of cytoskeleton (F)PMID:19346310ECO:0000270 expression pattern evidence used in manual assertion

Fig 2

challenge
acceptableHUMAN:IGF1RWedde001, Team The Dynamic Protein Duo2012-02-09 11:55:21 CSTGO:0004713 protein tyrosine kinase activity (F)PMID:11884589ECO:0000315 mutant phenotype evidence used in manual assertion

Fig1B

challenge

Pages in category "Team The Dynamic Protein Duo"

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