MOUSE:UCP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ucp2 (synonyms: Slc25a8)
Protein Name(s)	Mitochondrial uncoupling protein 2 UCP 2 Solute carrier family 25 member 8 UCPH
External Links
UniProt	P70406
EMBL	U69135 U94593 AB012159 BC012697 BC012967
CCDS	CCDS21498.1
RefSeq	NP_035801.3 XP_006507642.1
UniGene	Mm.171378
PDB	2LCK
PDBsum	2LCK
ProteinModelPortal	P70406
SMR	P70406
PhosphoSite	P70406
PaxDb	P70406
PRIDE	P70406
DNASU	22228
Ensembl	ENSMUST00000126534
GeneID	22228
KEGG	mmu:22228
UCSC	uc009inb.2
CTD	7351
MGI	MGI:109354
eggNOG	NOG300436
HOGENOM	HOG000165140
HOVERGEN	HBG009528
InParanoid	P70406
KO	K15103
OMA	LLKAHLM
OrthoDB	EOG793B7Z
PhylomeDB	P70406
TreeFam	TF323211
Reactome	REACT_208819 REACT_237805
ChiTaRS	Ucp2
NextBio	302263
PRO	PR:P70406
Proteomes	UP000000589
Bgee	P70406
ExpressionAtlas	P70406
Genevestigator	P70406
GO	GO:0016021 GO:0005743 GO:0005739 GO:0007568 GO:0034198 GO:0071333 GO:0032869 GO:0007565 GO:0097421 GO:0006839 GO:0043066 GO:0061179 GO:0010942 GO:0051881 GO:0070542 GO:0001666 GO:0000303
Gene3D	1.50.40.10
InterPro	IPR002030 IPR018108 IPR023395
Pfam	PF00153
PRINTS	PR00784
SUPFAM	SSF103506
PROSITE	PS50920

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005743	mitochondrial inner membrane	PMID:22348126^[1]	ECO:0000314			C		Figure 2 overexpression of UCP2 in the brain results in less tissue damage after focal ischemia	complete CACAO 3831
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:28130074^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:22736029^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990845	adaptive thermogenesis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98894 PANTHER:PTN002378102	P		Seeded From UniProt	complete
involved_in	GO:1990542	mitochondrial transmembrane transport	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98894 PANTHER:PTN000642156 RGD:3931	P		Seeded From UniProt	complete
enables	GO:0017077	oxidative phosphorylation uncoupler activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1099787 MGI:MGI:98894 PANTHER:PTN000642156 RGD:3931 TAIR:locus:2080300	F		Seeded From UniProt	complete
involved_in	GO:0009409	response to cold	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002378102 RGD:3933	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010942	positive regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006839	mitochondrial transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55851	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:9054939^[7]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:P25874	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55851	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000303	response to superoxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3932	P		Seeded From UniProt	complete
involved_in	GO:1902600	proton transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0017077	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55851 ensembl:ENSP00000312029	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55851 ensembl:ENSP00000312029	P		Seeded From UniProt	complete
involved_in	GO:0097421	liver regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0006839	mitochondrial transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P56500 ensembl:ENSRNOP00000024156	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R5N5 ensembl:ENSP00000312029	C		Seeded From UniProt	complete
involved_in	GO:0006839	mitochondrial transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002030	P		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040062	F		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002030	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Haines, B & Li, PA (2012) Overexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia. PLoS ONE 7 e31739 PubMed GONUTS page
↑ Caron, A et al. (2017) Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie 134 118-126 PubMed GONUTS page
↑ Papkovskaia, TD et al. (2012) G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum. Mol. Genet. 21 4201-13 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Fleury, C et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15 269-72 PubMed GONUTS page

[PMID:22348126-1] Haines, B & Li, PA (2012) Overexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia. PLoS ONE 7 e31739 PubMed GONUTS page

[PMID:28130074-2] Caron, A et al. (2017) Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie 134 118-126 PubMed GONUTS page

[PMID:22736029-3] Papkovskaia, TD et al. (2012) G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum. Mol. Genet. 21 4201-13 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18614015-5] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-6] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:9054939-7] Fleury, C et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15 269-72 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

MOUSE:UCP2

Contents

Annotations

Notes

References

a

c

e

f

g

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools