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HUMAN:UCP2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) UCP2 (synonyms: SLC25A8)
Protein Name(s) Mitochondrial uncoupling protein 2

UCP 2 Solute carrier family 25 member 8 UCPH

External Links
UniProt P55851
EMBL U82819
U76367
U94592
AJ223477
AJ223478
AJ223479
AF019409
AF096289
AK222540
AK222557
DQ087219
BC011737
CCDS CCDS8228.1
RefSeq NP_003346.2
UniGene Hs.80658
ProteinModelPortal P55851
SMR P55851
BioGrid 113198
IntAct P55851
STRING 9606.ENSP00000312029
TCDB 2.A.29.3.4
PhosphoSite P55851
DMDM 2497981
PaxDb P55851
PRIDE P55851
DNASU 7351
Ensembl ENST00000310473
GeneID 7351
KEGG hsa:7351
UCSC uc001oup.1
CTD 7351
GeneCards GC11M073685
GeneReviews UCP2
H-InvDB HIX0095887
HGNC HGNC:12518
HPA CAB025583
MIM 601693
607447
neXtProt NX_P55851
Orphanet 276556
PharmGKB PA37165
eggNOG NOG300436
GeneTree ENSGT00760000119170
HOGENOM HOG000165140
HOVERGEN HBG009528
InParanoid P55851
KO K15103
OMA LLKAHLM
OrthoDB EOG793B7Z
PhylomeDB P55851
TreeFam TF323211
Reactome REACT_6196
REACT_6258
ChiTaRS UCP2
GeneWiki UCP2
GenomeRNAi 7351
NextBio 28778
PRO PR:P55851
Proteomes UP000005640
Bgee P55851
CleanEx HS_UCP2
ExpressionAtlas P55851
Genevestigator P55851
GO GO:0016021
GO:0005743
GO:0007568
GO:0044237
GO:0034198
GO:0071333
GO:0032869
GO:0007565
GO:0097421
GO:0006839
GO:0043066
GO:0061179
GO:0010942
GO:0015992
GO:0051881
GO:0022904
GO:0070542
GO:0001666
GO:0000303
GO:0044281
GO:0006810
Gene3D 1.50.40.10
InterPro IPR002030
IPR018108
IPR023395
Pfam PF00153
PRINTS PR00784
SUPFAM SSF103506
PROSITE PS50920

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001666

response to hypoxia

PMID:22292025[1]

ECO:0000314

P

Fig 1B - UCP2 levels increase as levels of hypoxia increase

complete
CACAO 3759

GO:0006915

apoptotic process

PMID:22292025[1]

ECO:0000314

P

Fig 3A overexpression of UCP2 under hypoxic conditions decreases levels of apoptosis

complete
CACAO 3760

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:28130074[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P70406

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

PMID:22292025[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

PMID:9196039[3]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:1990845

adaptive thermogenesis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN002378102

P

Seeded From UniProt

complete

involved_in

GO:1990542

mitochondrial transmembrane transport

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931

P

Seeded From UniProt

complete

enables

GO:0017077

oxidative phosphorylation uncoupler activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1099787
MGI:MGI:98894
PANTHER:PTN000642156
RGD:3931
TAIR:locus:2080300

F

Seeded From UniProt

complete

involved_in

GO:0009409

response to cold

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002378102
RGD:3933

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0097421

liver regeneration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0071333

cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0070542

response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0061179

negative regulation of insulin secretion involved in cellular response to glucose stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0034198

cellular response to amino acid starvation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0032869

cellular response to insulin stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0010942

positive regulation of cell death

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0009749

response to glucose

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

C

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0000303

response to superoxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P56500
ensembl:ENSRNOP00000024156

P

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70406
ensembl:ENSMUSP00000120967

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P70406
ensembl:ENSMUSP00000120967

P

Seeded From UniProt

complete

involved_in

GO:0006839

mitochondrial transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

P

Seeded From UniProt

complete

enables

GO:0022857

transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR040062

F

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002030

C

Seeded From UniProt

complete

involved_in

GO:1902600

proton transmembrane transport

PMID:9054939[5]
Reactome:R-HSA-167827
Reactome:R-HSA-166187

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

Reactome:R-HSA-170026
Reactome:R-HSA-166387
Reactome:R-HSA-166220
Reactome:R-HSA-166214

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0005743

mitochondrial inner membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0999
UniProtKB-SubCell:SL-0168

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Deng, S et al. (2012) UCP2 inhibits ROS-mediated apoptosis in A549 under hypoxic conditions. PLoS ONE 7 e30714 PubMed GONUTS page
  2. ↑ Caron, A et al. (2017) Loss of UCP2 impairs cold-induced non-shivering thermogenesis by promoting a shift toward glucose utilization in brown adipose tissue. Biochimie 134 118-126 PubMed GONUTS page
  3. ↑ Vidal-Puig, A et al. (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun. 235 79-82 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Fleury, C et al. (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat. Genet. 15 269-72 PubMed GONUTS page
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