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PMID:9196039

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Citation

Vidal-Puig, A, Solanes, G, Grujic, D, Flier, JS and Lowell, BB (1997) UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem. Biophys. Res. Commun. 235:79-82

Abstract

Uncoupling proteins (UCPs) are inner mitochondrial membrane transporters which dissipate the proton gradient, releasing stored energy as heat. UCP1 is expressed exclusively in brown adipocytes while UCP2 is expressed widely. We now report the molecular cloning of a third uncoupling protein homologue, designated UCP3. At the amino acid level, hUCP3 is 71% identical to hUCP2 and 57% identical to hUCP1. UCP3 is distinguished from UCP1 and UCP2 by its abundant and preferential expression in skeletal muscle in humans, and brown adipose tissue and skeletal muscle in rodents. Since skeletal muscle and brown adipose tissue are believed to be important sites for regulated energy expenditure in humans and rodents, respectively, UCP3 may be an important mediator of adaptive thermogenesis. Since UCP3 is minimally expressed in human heart and other critical organs, it is a promising target for anti-obesity drug development aimed at increasing thermogenesis.

Links

PubMed Online version:10.1006/bbrc.1997.6740

Keywords

Adipose Tissue, Brown/metabolism; Amino Acid Sequence; Blotting, Northern; Carrier Proteins/biosynthesis; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cloning, Molecular; Gene Expression Regulation; Humans; Ion Channels; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Membrane Transport Proteins; Mitochondria/metabolism; Mitochondrial Proteins; Molecular Sequence Data; Muscle, Skeletal/metabolism; Proteins/chemistry; Proteins/metabolism; RNA, Messenger/metabolism; Sequence Homology, Amino Acid

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:UCP2

located_in

GO:0005743: mitochondrial inner membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UCP3

enables

GO:0005215: transporter activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:UCP3

located_in

GO:0005743: mitochondrial inner membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:UCP3

involved_in

GO:1902600: proton transmembrane transport

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:UCP2

part_of

GO:0005743: mitochondrial inner membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete


See also

References

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