HUMAN:IGF1R

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IGF1R
Protein Name(s)	Insulin-like growth factor 1 receptor Insulin-like growth factor I receptor IGF-I receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain
External Links
UniProt	P08069
EMBL	X04434 AB425196 AY332722 AC055807 AC069029 AC118658 AC118660 BC113610 BC113612 M69229
CCDS	CCDS10378.1
PIR	A25690
RefSeq	NP_000866.1 NP_001278787.1
UniGene	Hs.643120 Hs.714012
PDB	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
PDBsum	1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU
ProteinModelPortal	P08069
SMR	P08069
BioGrid	109701
DIP	DIP-476N
IntAct	P08069
MINT	MINT-85902
STRING	9606.ENSP00000268035
BindingDB	P08069
ChEMBL	CHEMBL1957
DrugBank	DB00071 DB00047 DB00046 DB00030 DB01277
GuidetoPHARMACOLOGY	1801
PhosphoSite	P08069
DMDM	124240
MaxQB	P08069
PaxDb	P08069
PeptideAtlas	P08069
PRIDE	P08069
DNASU	3480
Ensembl	ENST00000268035
GeneID	3480
KEGG	hsa:3480
UCSC	uc002bul.3
CTD	3480
GeneCards	GC15P099192
HGNC	HGNC:5465
HPA	CAB010268
MIM	147370 270450
neXtProt	NX_P08069
Orphanet	73273
PharmGKB	PA29698
eggNOG	COG0515
GeneTree	ENSGT00760000118818
HOGENOM	HOG000038045
HOVERGEN	HBG006134
InParanoid	P08069
KO	K05087
OMA	NRCQKMC
OrthoDB	EOG73RB9N
PhylomeDB	P08069
TreeFam	TF351636
BRENDA	2.7.10.1
Reactome	REACT_150139 REACT_150203 REACT_150359
SignaLink	P08069
ChiTaRS	IGF1R
EvolutionaryTrace	P08069
GeneWiki	Insulin-like_growth_factor_1_receptor
GenomeRNAi	3480
NextBio	13682
PRO	PR:P08069
Proteomes	UP000005640
Bgee	P08069
CleanEx	HS_IGF1R
ExpressionAtlas	P08069
Genevestigator	P08069
GO	GO:0005901 GO:0005887 GO:0043231 GO:0016020 GO:0043005 GO:0005886 GO:0043235 GO:0005524 GO:0042802 GO:0043559 GO:0005158 GO:0043560 GO:0005520 GO:0031994 GO:0005010 GO:0043548 GO:0004713 GO:0007409 GO:0007420 GO:0008544 GO:0030010 GO:0031017 GO:0006955 GO:0051389 GO:0008286 GO:0048009 GO:0030238 GO:0030879 GO:0043066 GO:0010656 GO:0051898 GO:0043433 GO:0038083 GO:0014065 GO:0048015 GO:0030335 GO:0008284 GO:0032467 GO:0045740 GO:0043410 GO:0045840 GO:0051897 GO:0090031 GO:0060740 GO:0046777 GO:0051291 GO:0051262 GO:0046328 GO:0033197 GO:0007165
Gene3D	2.60.40.10 3.80.20.20
InterPro	IPR003961 IPR006211 IPR006212 IPR009030 IPR013783 IPR011009 IPR000719 IPR017441 IPR000494 IPR001245 IPR008266 IPR020635 IPR016246 IPR002011
Pfam	PF00041 PF00757 PF07714 PF01030
PIRSF	PIRSF000620
PRINTS	PR00109
SMART	SM00060 SM00261 SM00219
SUPFAM	SSF49265 SSF56112 SSF57184
PROSITE	PS50853 PS00107 PS50011 PS00109 PS00239

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004713	protein tyrosine kinase activity	PMID:11884589^[1]	ECO:0000315			F		Fig1B	complete CACAO 3654
	GO:0001006	RNA polymerase III type 3 promoter sequence-specific DNA binding	PMID:23071652^[2]	ECO:0000314			F		Figure 2. The standard curves of IGF signaling antibody array. This graph shows the binding sites of the DNA	complete CACAO 5368
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26910308^[3]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60751	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:22635104^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05019	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	PMID:19578119^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex	PMID:19578119^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q05688	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:I3PGL2	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1K218	C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11884589^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	PMID:7692086^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:12138094^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043559	insulin binding	PMID:8452530^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01308	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:8452530^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031994	insulin-like growth factor I binding	PMID:8452530^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05019	F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:12138094^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8452530^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014065	phosphatidylinositol 3-kinase signaling	PMID:7541045^[9]	ECO:0000305	curator inference used in manual assertion	GO:0043548	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:16886151^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:8452530^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097062	dendritic spine maintenance	PMID:19406747^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24062	P	part_of:(GO:0008286) occurs_in:(CL:0002608) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0043243	positive regulation of protein complex disassembly	PMID:19406747^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24062	P	occurs_in:(CL:0002609) part_of:(GO:0008286) regulates_o_occurs_in:(GO:0005576) has_input:(ComplexPortal:CPX-1134) has_output:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:19406747^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P24062	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	PMID:19406747^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0008286) has_target_end_location:(GO:0005576) has_target_start_location:(GO:0005576)	Seeded From UniProt	complete
involved_in	GO:0051389	inactivation of MAPKK activity	PMID:12556535^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:1846292^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:7679099^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:7679099^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:1846292^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11162456^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	PMID:12556535^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:7541045^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35568	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:7541045^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P27986	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12556535^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7679099^[14]	ECO:0000305	curator inference used in manual assertion	GO:0005010	C		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	PMID:7679099^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005520	insulin-like growth factor binding	PMID:1846292^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005010	insulin-like growth factor-activated receptor activity	PMID:7679099^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11162456^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7679099^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699676 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
involved_in	GO:0048856	anatomical structure development	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346037 MGI:MGI:96433 MGI:MGI:96575 PANTHER:PTN002521379 RGD:2869 RGD:2917 UniProtKB:P06213 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-020503-3 ZFIN:ZDB-GENE-020503-4	P		Seeded From UniProt	complete
involved_in	GO:0048009	insulin-like growth factor receptor signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814784 RGD:2869 UniProtKB:P08069 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2	P		Seeded From UniProt	complete
involved_in	GO:0046328	regulation of JNK cascade	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814784 UniProtKB:P08069	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213 UniProtKB:P08069	F		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96433 PANTHER:PTN000699611 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 MGI:MGI:96433 PANTHER:PTN000699611 RGD:2869 RGD:2917 UniProtKB:P06213	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002400529 RGD:2869	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2869 WB:WBGene00000898	C		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0283499 PANTHER:PTN000699611 RGD:2869	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005899	insulin receptor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 UniProtKB:P06213	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005009	insulin-activated receptor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000699611 RGD:2917 UniProtKB:P06213	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:19545541^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21645859^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17586502^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:11448933^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08069	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211 InterPro:IPR016246	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002011 InterPro:IPR006211	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	C		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016246	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8710868^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:10829031^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10749889^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:3003744^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005010	insulin-like growth factor-activated receptor activity	PMID:10749889^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5686072 Reactome:R-HSA-2428930 Reactome:R-HSA-2428926 Reactome:R-HSA-2428922 Reactome:R-HSA-2404200 Reactome:R-HSA-2404199 Reactome:R-HSA-2404195 Reactome:R-HSA-2404193	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-HSA-2404199	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Buckley, DA et al. (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol. Cell. Biol. 22 1998-2010 PubMed GONUTS page
↑ Zhou, Q et al. (2012) Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers. PLoS ONE 7 e46851 PubMed GONUTS page
↑ Viana-Huete, V et al. (2016) Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology 157 1495-511 PubMed GONUTS page
↑ Ito, S et al. (2012) Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-β peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus. J. Alzheimers Dis. 31 493-506 PubMed GONUTS page
↑ ^5.0 ^5.1 Saegusa, J et al. (2009) The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. J. Biol. Chem. 284 24106-14 PubMed GONUTS page
↑ Liu, D et al. (1993) Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J. Virol. 67 6835-40 PubMed GONUTS page
↑ ^7.0 ^7.1 Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Soos, MA et al. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290 ( Pt 2) 419-26 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page
↑ Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Zhao, WQ et al. (2009) Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. J. Biol. Chem. 284 18742-53 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Galvan, V et al. (2003) Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J. Biol. Chem. 278 13325-32 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Tollefsen, SE et al. (1991) Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. Biochemistry 30 48-54 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Kato, H et al. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J. Biol. Chem. 268 2655-61 PubMed GONUTS page
↑ ^15.0 ^15.1 Lopaczynski, W et al. (2000) Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. Biochem. Biophys. Res. Commun. 279 955-60 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 ^16.14 ^16.15 ^16.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Andersson, S et al. (2009) Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor. Biochem. Biophys. Res. Commun. 387 36-41 PubMed GONUTS page
↑ Houde, D & Demarest, SJ (2011) Fine details of IGF-1R activation, inhibition, and asymmetry determined by associated hydrogen /deuterium-exchange and peptide mass mapping. Structure 19 890-900 PubMed GONUTS page
↑ Craddock, BP et al. (2007) Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region. FEBS Lett. 581 3235-40 PubMed GONUTS page
↑ Reiss, K et al. (2001) Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin. Cancer Res. 7 2134-44 PubMed GONUTS page
↑ Werner, H et al. (1996) Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. U.S.A. 93 8318-23 PubMed GONUTS page
↑ Fasshauer, M et al. (2000) Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J. Biol. Chem. 275 25494-501 PubMed GONUTS page
↑ ^24.0 ^24.1 Kahlert, S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J. Biol. Chem. 275 18447-53 PubMed GONUTS page
↑ Flier, JS et al. (1986) Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 83 664-8 PubMed GONUTS page

[PMID:11884589-1] 1.0 ^1.1 Buckley, DA et al. (2002) Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Mol. Cell. Biol. 22 1998-2010 PubMed GONUTS page

[PMID:23071652-2] Zhou, Q et al. (2012) Development of IGF signaling antibody arrays for the identification of hepatocellular carcinoma biomarkers. PLoS ONE 7 e46851 PubMed GONUTS page

[PMID:26910308-3] Viana-Huete, V et al. (2016) Essential Role of IGFIR in the Onset of Male Brown Fat Thermogenic Function: Regulation of Glucose Homeostasis by Differential Organ-Specific Insulin Sensitivity. Endocrinology 157 1495-511 PubMed GONUTS page

[PMID:22635104-4] Ito, S et al. (2012) Involvement of insulin-like growth factor 1 receptor signaling in the amyloid-β peptide oligomers-induced p75 neurotrophin receptor protein expression in mouse hippocampus. J. Alzheimers Dis. 31 493-506 PubMed GONUTS page

[PMID:19578119-5] 5.0 ^5.1 Saegusa, J et al. (2009) The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling. J. Biol. Chem. 284 24106-14 PubMed GONUTS page

[PMID:7692086-6] Liu, D et al. (1993) Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J. Virol. 67 6835-40 PubMed GONUTS page

[PMID:12138094-7] 7.0 ^7.1 Pandini, G et al. (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J. Biol. Chem. 277 39684-95 PubMed GONUTS page

[PMID:8452530-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Soos, MA et al. (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem. J. 290 ( Pt 2) 419-26 PubMed GONUTS page

[PMID:7541045-9] 9.0 ^9.1 ^9.2 Craparo, A et al. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270 15639-43 PubMed GONUTS page

[PMID:16886151-10] Adewoye, AH et al. (2006) Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia. Clin. Infect. Dis. 43 593-8 PubMed GONUTS page

[PMID:19406747-11] 11.0 ^11.1 ^11.2 ^11.3 Zhao, WQ et al. (2009) Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. J. Biol. Chem. 284 18742-53 PubMed GONUTS page

[PMID:12556535-12] 12.0 ^12.1 ^12.2 Galvan, V et al. (2003) Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1). J. Biol. Chem. 278 13325-32 PubMed GONUTS page

[PMID:1846292-13] 13.0 ^13.1 ^13.2 Tollefsen, SE et al. (1991) Interaction of the alpha beta dimers of the insulin-like growth factor I receptor is required for receptor autophosphorylation. Biochemistry 30 48-54 PubMed GONUTS page

[PMID:7679099-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Kato, H et al. (1993) Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). J. Biol. Chem. 268 2655-61 PubMed GONUTS page

[PMID:11162456-15] 15.0 ^15.1 Lopaczynski, W et al. (2000) Autophosphorylation of the insulin-like growth factor I receptor cytoplasmic domain. Biochem. Biophys. Res. Commun. 279 955-60 PubMed GONUTS page

[PMID:21873635-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 ^16.12 ^16.13 ^16.14 ^16.15 ^16.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23382219-17] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:19545541-18] Andersson, S et al. (2009) Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor. Biochem. Biophys. Res. Commun. 387 36-41 PubMed GONUTS page

[PMID:21645859-19] Houde, D & Demarest, SJ (2011) Fine details of IGF-1R activation, inhibition, and asymmetry determined by associated hydrogen /deuterium-exchange and peptide mass mapping. Structure 19 890-900 PubMed GONUTS page

[PMID:17586502-20] Craddock, BP et al. (2007) Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region. FEBS Lett. 581 3235-40 PubMed GONUTS page

[PMID:11448933-21] Reiss, K et al. (2001) Intracellular association of a mutant insulin-like growth factor receptor with endogenous receptors. Clin. Cancer Res. 7 2134-44 PubMed GONUTS page

[PMID:8710868-22] Werner, H et al. (1996) Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. Proc. Natl. Acad. Sci. U.S.A. 93 8318-23 PubMed GONUTS page

[PMID:10829031-23] Fasshauer, M et al. (2000) Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J. Biol. Chem. 275 25494-501 PubMed GONUTS page

[PMID:10749889-24] 24.0 ^24.1 Kahlert, S et al. (2000) Estrogen receptor alpha rapidly activates the IGF-1 receptor pathway. J. Biol. Chem. 275 18447-53 PubMed GONUTS page

[PMID:3003744-25] Flier, JS et al. (1986) Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 83 664-8 PubMed GONUTS page

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HUMAN:IGF1R

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