Category:Gene-ius

Figures 1,3,4: Activation of c-Abl protein tyrosine kinase regulates DNA damage-induced apoptosis; an overexpression shows a significant difference in number of dead cells.

Figure 4: Parkin (E3 ubiquitin-ligase) binds PICK1 protein which mediates and promotes monoubiquitination of PICK1.

Figures 4,6,8: Axin activates HIPK2 (homeodomain-interacting protein kinase-2)-mediated p53 phosphorylation and p53-dependent transcription and apoptosis.

Figure 5: Overexpression of SPATA17 leads to increased apoptosis in spermatogonia. Determined by Western Blot.

Figure 6: Mutation of all seven SQ/TQ motifs significantly reduced phosphorylation and activation of Chk2 protein kinase in response to DNA damage by Ionizing Radiation.

Figures 5 and 6: Wild-type compared to knockout mutant.

Figure 4. Wild-type oocyte growth compared to knock-out oocyte growth.

Figures 4-10: Ubiquitin ligase E6AP binds to HCV (Hepatitis C Virus) core protein to mediate and promote ubiquitination and degradation of the core protein.