HUMAN:ATM

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ATM
Protein Name(s)	Serine-protein kinase ATM Ataxia telangiectasia mutated A-T mutated
External Links
UniProt	Q13315
EMBL	U33841 U55757 U55704 U55705 U55707 U55708 U55709 U55710 U55711 U55712 U55713 U55714 U55715 U55716 U55717 U55718 U55719 U55720 U55721 U55722 U55723 U55724 U55725 U55726 U55727 U55728 U55729 U55730 U55731 U55732 U55733 U55734 U55735 U55736 U55737 U55738 U55739 U55740 U55741 U55742 U55743 U55744 U55745 U55746 U55747 U55748 U55749 U55750 U55751 U55752 U55753 U55754 U55755 U55756 U55757 U55726 U55727 U55728 U55729 U55730 U55731 U55732 U55733 U55734 U55735 U55736 U55737 U55738 U55739 U55740 U55741 U55742 U55743 U55744 U55745 U55746 U55747 U55748 U55749 U55750 U55751 U55752 U55753 U55754 U55755 U55756 U82828 AP001925 AP005718 KF455499 CH471065 X91196 U67092 AY220758 U26455 BC137169
CCDS	CCDS31669.1
PIR	A43100
RefSeq	NP_000042.3 XP_005271618.2 XP_005271619.2 XP_006718906.1 XP_006718908.1
UniGene	Hs.367437
ProteinModelPortal	Q13315
SMR	Q13315
BioGrid	106962
DIP	DIP-182N
IntAct	Q13315
MINT	MINT-194471
STRING	9606.ENSP00000278616
BindingDB	Q13315
ChEMBL	CHEMBL3797
DrugBank	DB00201
GuidetoPHARMACOLOGY	1934
PhosphoSite	Q13315
DMDM	317373479
MaxQB	Q13315
PaxDb	Q13315
PRIDE	Q13315
DNASU	472
Ensembl	ENST00000278616 ENST00000452508
GeneID	472
KEGG	hsa:472
UCSC	uc001pkb.1
CTD	472
GeneCards	GC11P108093
GeneReviews	ATM
H-InvDB	HIX0010089 HIX0201637
HGNC	HGNC:795
HPA	CAB000102
MIM	208900 607585
neXtProt	NX_Q13315
Orphanet	100 370109 67038 370114 52416
PharmGKB	PA61
eggNOG	COG5032
GeneTree	ENSGT00670000098061
HOVERGEN	HBG004304
InParanoid	Q13315
KO	K04728
PhylomeDB	Q13315
TreeFam	TF101182
Reactome	REACT_1614 REACT_169185 REACT_18265 REACT_1924 REACT_200780 REACT_204 REACT_20549 REACT_27271 REACT_309 REACT_897 REACT_97
SignaLink	Q13315
ChiTaRS	ATM
GeneWiki	Ataxia_telangiectasia_mutated
GenomeRNAi	472
NextBio	1949
PRO	PR:Q13315
Proteomes	UP000005640
Bgee	Q13315
CleanEx	HS_ATM
ExpressionAtlas	Q13315
Genevestigator	Q13315
GO	GO:0016023 GO:0005654 GO:0005819 GO:0016303 GO:0005524 GO:0003677 GO:0004677 GO:0035174 GO:0032403 GO:0046983 GO:0047485 GO:0004674 GO:0007420 GO:0007050 GO:0006974 GO:0071480 GO:0006975 GO:0006977 GO:0006281 GO:0006302 GO:0000724 GO:0007507 GO:0071044 GO:0008630 GO:0042159 GO:0007094 GO:0030889 GO:0051402 GO:0048599 GO:0018105 GO:0036092 GO:0043065 GO:0043517 GO:0043525 GO:0002331 GO:0046777 GO:0006468 GO:0007131 GO:0090399 GO:0001666 GO:0010212 GO:0007165 GO:0072434 GO:0001756 GO:0000723
Gene3D	1.10.1070.11
InterPro	IPR016024 IPR015519 IPR003152 IPR011009 IPR000403 IPR018936 IPR003151 IPR014009 IPR021668
PANTHER	PTHR11139:SF66
Pfam	PF02259 PF02260 PF00454 PF11640
SMART	SM00146
SUPFAM	SSF48371 SSF56112
PROSITE	PS51189 PS51190 PS00915 PS00916 PS50290

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045860	positive regulation of protein kinase activity	PMID:10973490^[1]	ECO:0000315			P		Figure 6: Mutation of all seven SQ/TQ motifs significantly reduced phosphorylation and activation of Chk2 protein kinase in response to DNA damage by Ionizing Radiation.	complete CACAO 3562
	GO:0004674	protein serine/threonine kinase activity	PMID:22266654^[2]	ECO:0000314			F		ATM phosphorylates TRF1 at serine367: Figure 1.	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:30612738^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62388	P		Seeded From UniProt	complete
	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:25625042^[4]	ECO:0000314			F			complete CACAO 10707
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62388	P	regulates_expression_of:(ENSEMBL:ENSG00000140836) part_of:(GO:0071300)\|regulates_expression_of(ENSEMBL:ENSG00000113721)\|regulates_expression_of(ENSEMBL:ENSG00000077943)\|regulates_expression_of(ENSEMBL:ENSG00000168542)	Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62388	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:28344092^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:28344092^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000101412)	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:27829214^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26323318^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071481	cellular response to X-ray	PMID:26323318^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:26323318^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q9H1E3) part_of:(GO:0071481)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:26323318^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q9H1E3) part_of:(GO:0071481)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:17694070^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	PMID:17694070^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904354	negative regulation of telomere capping	PMID:17694070^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P54274)	Seeded From UniProt	complete
involved_in	GO:0097695	establishment of protein-containing complex localization to telomere	PMID:26586433^[9]	ECO:0000305	curator inference used in manual assertion	GO:0097694	P	transports_or_maintains_localization_of:(ComplexPortal:CPX-17)	Seeded From UniProt	complete
involved_in	GO:1904884	positive regulation of telomerase catalytic core complex assembly	PMID:26586433^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032210	regulation of telomere maintenance via telomerase	PMID:26586433^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9NUX5	P		Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	PMID:26586433^[9]	ECO:0000305	curator inference used in manual assertion	GO:0097694	C		Seeded From UniProt	complete
involved_in	GO:0097694	establishment of RNA localization to telomere	PMID:26586433^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(GO:0000781)	Seeded From UniProt	complete
NOT\|involved_in	GO:0051972	regulation of telomerase activity	PMID:26586427^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904358	positive regulation of telomere maintenance via telomere lengthening	PMID:26586427^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62388	P		Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:23878245^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071500)	Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:23878245^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0071500)	Seeded From UniProt	complete
involved_in	GO:0071500	cellular response to nitrosative stress	PMID:23878245^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:16213212^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:16213212^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:27664052^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:27664052^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:15149599^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072434	signal transduction involved in mitotic G2 DNA damage checkpoint	PMID:15149599^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:9925639^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:15790808^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:15790808^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:9733515^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	PMID:9733515^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:15790808^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:9733515^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:9733515^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:15149599^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:9733515^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15790808^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004677	DNA-dependent protein kinase activity	PMID:15790808^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9733515^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	PMID:15149599^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071044	histone mRNA catabolic process	PMID:16086026^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11375976^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17875758^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	PMID:17875758^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016303	1-phosphatidylinositol-3-kinase activity	PMID:11375976^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	PMID:11375976^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007094	mitotic spindle assembly checkpoint	PMID:11943150^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17875758^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15916964^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:20096447^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11375976^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002331	pre-B cell allelic exclusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62388	P		Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107202 PANTHER:PTN001673294 UniProtKB:Q13315	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107202 PANTHER:PTN001673294 ZFIN:ZDB-GENE-040809-1	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107202 PANTHER:PTN001673294 RGD:1593265 SGD:S000000184 UniProtKB:Q13315	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 FB:FBgn0053554 MGI:MGI:104779 MGI:MGI:1928394 PANTHER:PTN000124197 RGD:1593265 RGD:68371 SGD:S000000340 SGD:S000001141 SGD:S000003827 UniProtKB:P78527 UniProtKB:Q13315 UniProtKB:Q96Q15 UniProtKB:Q9FR53 UniProtKB:Q9Y4A5 WB:WBGene00000226 WB:WBGene00007028	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001673294 PomBase:SPCC23B6.03c SGD:S000000184 UniProtKB:Q13315	F		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0045035 PANTHER:PTN001673294 PomBase:SPCC23B6.03c SGD:S000000184	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:21873635^[24]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107202 PANTHER:PTN001673294 ZFIN:ZDB-GENE-040809-1	P		Seeded From UniProt	complete
part_of	GO:1990391	DNA repair complex	PMID:24217620^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036289	peptidyl-serine autophosphorylation	PMID:24550317^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:24550317^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016303	P		Seeded From UniProt	complete
involved_in	GO:2001022	positive regulation of response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:1905843	regulation of cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:1903978	regulation of microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:1903626	positive regulation of DNA catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:0033129	positive regulation of histone phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4ACL8 ensembl:ENSRNOP00000045529	P		Seeded From UniProt	complete
involved_in	GO:1904262	negative regulation of TORC1 signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0070192	chromosome organization involved in meiotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0048599	oocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0045141	meiotic telomere clustering	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0042159	lipoprotein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0033151	V(D)J recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0008585	female gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0007292	female gamete generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0007143	female meiotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0007140	male meiotic nuclear division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	F		Seeded From UniProt	complete
involved_in	GO:0002377	immunoglobulin production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0002331	pre-B cell allelic exclusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62388 ensembl:ENSMUSP00000156344	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519 InterPro:IPR021668	F		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
involved_in	GO:0010212	response to ionizing radiation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018936 InterPro:IPR036940	F		Seeded From UniProt	complete
involved_in	GO:0016572	histone phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015519	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7792600^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007131	reciprocal meiotic recombination	PMID:7792600^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-6804955 Reactome:R-HSA-6804276 Reactome:R-HSA-6800490 Reactome:R-HSA-6799097 Reactome:R-HSA-6798372 Reactome:R-HSA-5693609 Reactome:R-HSA-5693598 Reactome:R-HSA-5693551 Reactome:R-HSA-5693549 Reactome:R-HSA-5693536 Reactome:R-HSA-5686704 Reactome:R-HSA-5686578 Reactome:R-HSA-5684140 Reactome:R-HSA-5683964 Reactome:R-HSA-5683425 Reactome:R-HSA-5682983 Reactome:R-HSA-5682598 Reactome:R-HSA-349455 Reactome:R-HSA-349444 Reactome:R-HSA-69891	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	Reactome:R-HSA-5693608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:R-HSA-69563	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	Reactome:R-HSA-5693571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-5684875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-69891 Reactome:R-HSA-6804955 Reactome:R-HSA-6804276 Reactome:R-HSA-6800490 Reactome:R-HSA-6799332 Reactome:R-HSA-6799097 Reactome:R-HSA-6798372 Reactome:R-HSA-6792712 Reactome:R-HSA-5693620 Reactome:R-HSA-5693612 Reactome:R-HSA-5693609 Reactome:R-HSA-5693608 Reactome:R-HSA-5693602 Reactome:R-HSA-5693599 Reactome:R-HSA-5693598 Reactome:R-HSA-5693593 Reactome:R-HSA-5693589 Reactome:R-HSA-5693584 Reactome:R-HSA-5693583 Reactome:R-HSA-5693580 Reactome:R-HSA-5693566 Reactome:R-HSA-5693564 Reactome:R-HSA-5693561 Reactome:R-HSA-5693551 Reactome:R-HSA-5693549 Reactome:R-HSA-5693542 Reactome:R-HSA-5693540 Reactome:R-HSA-5693539 Reactome:R-HSA-5693536 Reactome:R-HSA-5686900 Reactome:R-HSA-5686704 Reactome:R-HSA-5686685 Reactome:R-HSA-5686657 Reactome:R-HSA-5686642 Reactome:R-HSA-5686578 Reactome:R-HSA-5686483 Reactome:R-HSA-5686469 Reactome:R-HSA-5686440 Reactome:R-HSA-5686410 Reactome:R-HSA-5685994 Reactome:R-HSA-5685985 Reactome:R-HSA-5685838 Reactome:R-HSA-5685341 Reactome:R-HSA-5685156 Reactome:R-HSA-5685011 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-5684875 Reactome:R-HSA-5684140 Reactome:R-HSA-5684108 Reactome:R-HSA-5684096 Reactome:R-HSA-5684081 Reactome:R-HSA-5684071 Reactome:R-HSA-5684052 Reactome:R-HSA-5683986 Reactome:R-HSA-5683967 Reactome:R-HSA-5683964 Reactome:R-HSA-5683801 Reactome:R-HSA-5683735 Reactome:R-HSA-5683425 Reactome:R-HSA-5683405 Reactome:R-HSA-5683385 Reactome:R-HSA-5683384 Reactome:R-HSA-5683077 Reactome:R-HSA-5682992 Reactome:R-HSA-5682983 Reactome:R-HSA-5682967 Reactome:R-HSA-5682965 Reactome:R-HSA-5682863 Reactome:R-HSA-5682858 Reactome:R-HSA-5682629 Reactome:R-HSA-5682607 Reactome:R-HSA-5682598 Reactome:R-HSA-5682588 Reactome:R-HSA-5682586 Reactome:R-HSA-5682044 Reactome:R-HSA-5682026 Reactome:R-HSA-5682018 Reactome:R-HSA-349455 Reactome:R-HSA-349444 Reactome:R-HSA-3371567	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Matsuoka, S et al. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. U.S.A. 97 10389-94 PubMed GONUTS page
↑ McKerlie, M et al. (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res. 40 3975-89 PubMed GONUTS page
↑ Jachimowicz, RD et al. (2019) UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell 176 505-519.e22 PubMed GONUTS page
↑ Mangone, FR et al. (2015) ATM gene mutations in sporadic breast cancer patients from Brazil. Springerplus 4 23 PubMed GONUTS page
↑ ^5.0 ^5.1 Chen, S et al. (2017) The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Int. J. Biol. Macromol. 102 718-728 PubMed GONUTS page
↑ Chen, H et al. (2016) PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget 7 83241-83257 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Parplys, AC et al. (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 43 9817-34 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Wu, Y et al. (2007) MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol. 14 832-40 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page
↑ ^10.0 ^10.1 Lee, SS et al. (2015) ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell Rep 13 1623-32 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Tripathi, DN et al. (2013) Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc. Natl. Acad. Sci. U.S.A. 110 E2950-7 PubMed GONUTS page
↑ ^12.0 ^12.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page
↑ ^13.0 ^13.1 Carranza, D et al. (2017) Molecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-Telangiectasia. Neuromolecular Med. 19 161-174 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
↑ Tibbetts, RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13 152-7 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 Lee, JH & Paull, TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 551-4 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Canman, CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281 1677-9 PubMed GONUTS page
↑ Kaygun, H & Marzluff, WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat. Struct. Mol. Biol. 12 794-800 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Kishi, S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J. Biol. Chem. 276 29282-91 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
↑ Nakamura, M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 514 193-8 PubMed GONUTS page
↑ Bhoumik, A et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell 18 577-87 PubMed GONUTS page
↑ Yuan, J et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140 384-96 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page
↑ ^26.0 ^26.1 Khoury-Haddad, H et al. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 111 E728-37 PubMed GONUTS page
↑ ^27.0 ^27.1 Savitsky, K et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268 1749-53 PubMed GONUTS page

[PMID:10973490-1] Matsuoka, S et al. (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc. Natl. Acad. Sci. U.S.A. 97 10389-94 PubMed GONUTS page

[PMID:22266654-2] McKerlie, M et al. (2012) ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic Acids Res. 40 3975-89 PubMed GONUTS page

[PMID:30612738-3] Jachimowicz, RD et al. (2019) UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors. Cell 176 505-519.e22 PubMed GONUTS page

[PMID:25625042-4] Mangone, FR et al. (2015) ATM gene mutations in sporadic breast cancer patients from Brazil. Springerplus 4 23 PubMed GONUTS page

[PMID:28344092-5] 5.0 ^5.1 Chen, S et al. (2017) The over expression of long non-coding RNA ANRIL promotes epithelial-mesenchymal transition by activating the ATM-E2F1 signaling pathway in pancreatic cancer: An in vivo and in vitro study. Int. J. Biol. Macromol. 102 718-728 PubMed GONUTS page

[PMID:27829214-6] Chen, H et al. (2016) PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. Oncotarget 7 83241-83257 PubMed GONUTS page

[PMID:26323318-7] 7.0 ^7.1 ^7.2 ^7.3 Parplys, AC et al. (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 43 9817-34 PubMed GONUTS page

[PMID:17694070-8] 8.0 ^8.1 ^8.2 Wu, Y et al. (2007) MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat. Struct. Mol. Biol. 14 832-40 PubMed GONUTS page

[PMID:26586433-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Tong, AS et al. (2015) ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres. Cell Rep 13 1633-46 PubMed GONUTS page

[PMID:26586427-10] 10.0 ^10.1 Lee, SS et al. (2015) ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells. Cell Rep 13 1623-32 PubMed GONUTS page

[PMID:23878245-11] 11.0 ^11.1 ^11.2 Tripathi, DN et al. (2013) Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc. Natl. Acad. Sci. U.S.A. 110 E2950-7 PubMed GONUTS page

[PMID:16213212-12] 12.0 ^12.1 Takagi, M et al. (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123 49-63 PubMed GONUTS page

[PMID:27664052-13] 13.0 ^13.1 Carranza, D et al. (2017) Molecular and Functional Characterization of a Cohort of Spanish Patients with Ataxia-Telangiectasia. Neuromolecular Med. 19 161-174 PubMed GONUTS page

[PMID:15149599-14] 14.0 ^14.1 ^14.2 ^14.3 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page

[PMID:9925639-15] Tibbetts, RS et al. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13 152-7 PubMed GONUTS page

[PMID:15790808-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 Lee, JH & Paull, TT (2005) ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 551-4 PubMed GONUTS page

[PMID:9733515-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Canman, CE et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281 1677-9 PubMed GONUTS page

[PMID:16086026-18] Kaygun, H & Marzluff, WF (2005) Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1. Nat. Struct. Mol. Biol. 12 794-800 PubMed GONUTS page

[PMID:11375976-19] 19.0 ^19.1 ^19.2 ^19.3 Kishi, S et al. (2001) Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks. J. Biol. Chem. 276 29282-91 PubMed GONUTS page

[PMID:17875758-20] 20.0 ^20.1 ^20.2 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page

[PMID:11943150-21] Nakamura, M et al. (2002) Involvement of the telomeric protein Pin2/TRF1 in the regulation of the mitotic spindle. FEBS Lett. 514 193-8 PubMed GONUTS page

[PMID:15916964-22] Bhoumik, A et al. (2005) ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol. Cell 18 577-87 PubMed GONUTS page

[PMID:20096447-23] Yuan, J et al. (2010) USP10 regulates p53 localization and stability by deubiquitinating p53. Cell 140 384-96 PubMed GONUTS page

[PMID:21873635-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24217620-25] Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

[PMID:24550317-26] 26.0 ^26.1 Khoury-Haddad, H et al. (2014) PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 111 E728-37 PubMed GONUTS page

[PMID:7792600-27] 27.0 ^27.1 Savitsky, K et al. (1995) A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268 1749-53 PubMed GONUTS page

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