User:Stell006

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	HUMAN:UBE3A	2011-12-09 16:41:54 CST	GO:0031398 regulation of protein ubiquitination (P)	PMID:17108031	ECO:0000314 direct assay evidence used in manual assertion	Figures 4-10: Ubiquitin ligase E6AP binds to HCV (Hepatitis C Virus) core protein to mediate and promote ubiquitination and degradation of the core protein.	challenge
requireschanges	HUMAN:ATM	2011-12-11 10:21:07 CST	GO:0045860 positive regulation of protein kinase activity (P)	PMID:10973490	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 6: Mutation of all seven SQ/TQ motifs significantly reduced phosphorylation and activation of Chk2 protein kinase in response to DNA damage by Ionizing Radiation.	challenge
acceptable	MOUSE:AXIN1	2011-12-11 21:00:19 CST	GO:0045860 positive regulation of protein kinase activity (P)	PMID:15526030	ECO:0000314 direct assay evidence used in manual assertion	Figures 4,6,8: Axin activates HIPK2 (homeodomain-interacting protein kinase-2)-mediated p53 phosphorylation and p53-dependent transcription and apoptosis.	challenge
requireschanges	MOUSE:PRKN2	2011-12-11 22:05:53 CST	GO:0031398 positive regulation of protein ubiquitination (P)	PMID:17553932	ECO:0000314 direct assay evidence used in manual assertion	Figure 4: Parkin (E3 ubiquitin-ligase) binds PICK1 protein which mediates and promotes monoubiquitination of PICK1.	challenge
acceptable	HUMAN:ABL1	2011-12-11 22:57:21 CST	GO:0043065 positive regulation of apoptosis (P)	PMID:9037071	ECO:0000314 direct assay evidence used in manual assertion	Figures 1,3,4: Activation of c-Abl protein tyrosine kinase regulates DNA damage-induced apoptosis; an overexpression shows a significant difference in number of dead cells.	challenge

acceptable:3
unacceptable:0
requires_changes:2
flagged:0

Annotations challenged by Stell006

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history

0 annotations fixed by Stell006