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MOUSE:Q2TVT7

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Foxl2 (ECO:0000313 with EMBL:AAM21968.1, ECO:0000313 with MGI:MGI:1349428)
Protein Name(s) Forkhead box L2 (ECO:0000313 with EMBL:AAI37812.1)

Putative transcription factor foxl2 (ECO:0000313 with EMBL:AAM21968.1)

External Links
UniProt Q2TVT7
EMBL BC137811
BC137812
AY094605
RefSeq NP_036150.1
UniGene Mm.151239
SMR Q2TVT7
GeneID 26927
KEGG mmu:26927
CTD 668
MGI MGI:1349428
GeneTree ENSGT00760000118904
HOVERGEN HBG051651
KO K09405
OMA ELSMMHC
PhylomeDB Q2TVT7
NextBio 304821
Genevestigator Q2TVT7
GO GO:0005634
GO:0043028
GO:0003677
GO:0043565
GO:0003700
GO:0006309
GO:0048048
GO:0002074
GO:0019101
GO:0060014
GO:0000122
GO:0045892
GO:0001541
GO:0043280
GO:0045944
GO:0006351
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00657
PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001555

oocyte growth

PMID:15056605[1]

ECO:0000315

P

Figure 4. Wild-type oocyte growth compared to knock-out oocyte growth.

complete
CACAO 3552

GO:0048048

embryonic eye morphogenesis

PMID:11175783[2]

ECO:0000315

P

Figures 5 and 6: Wild-type compared to knockout mutant.

complete
CACAO 3553

involved_in

GO:0048048

embryonic eye morphogenesis

PMID:11175783[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001555

oocyte growth

PMID:15056605[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

part_of

GO:0045171

intercellular bridge

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

C

Seeded From UniProt

complete

involved_in

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

enables

GO:0043028

cysteine-type endopeptidase regulator activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

F

Seeded From UniProt

complete

enables

GO:0031624

ubiquitin conjugating enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

F

Seeded From UniProt

complete

involved_in

GO:0006309

apoptotic DNA fragmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

F

Seeded From UniProt

complete

involved_in

GO:0002074

extraocular skeletal muscle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

involved_in

GO:0001541

ovarian follicle development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P58012
ensembl:ENSP00000497217

P

Seeded From UniProt

complete

part_of

GO:0045171

intercellular bridge

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53ZD3
ensembl:ENSP00000497217

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q53ZD3
ensembl:ENSP00000497217

C

Seeded From UniProt

complete

enables

GO:0003700

DNA-binding transcription factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

P

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001766
InterPro:IPR018122
InterPro:IPR030456

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000040

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413741

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000413741

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Uda, M et al. (2004) Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum. Mol. Genet. 13 1171-81 PubMed GONUTS page
  2. 2.0 2.1 Crisponi, L et al. (2001) The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat. Genet. 27 159-66 PubMed GONUTS page