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Category:GO:0070578 ! RISC-loading complex

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DAG for GO:0070578id: GO:0070578

name: RISC-loading complex
namespace: cellular_component
def: "A trimeric protein complex required for the formation of a mature RNA-induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1), TRBP (TARBP2) and the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity." [GOC:ab, GOC:BHF, GOC:nc, GOC:rph, PMID:18178619, PMID:19820710]
synonym: "microRNA loading complex" EXACT [GOC:ab]
synonym: "miRLC" EXACT [GOC:ab]
synonym: "RLC" RELATED [GOC:ab, GOC:mah]
is_a: GO:1902555 ! endoribonuclease complex

AmiGO <GOterm>GO:0070578</GOterm>
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Pages in category "GO:0070578 ! RISC-loading complex"

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