HUMAN:TRBP2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TARBP2 (ECO:0000255 with HAMAP-Rule:MF_03034) (synonyms: TRBP)
Protein Name(s)	RISC-loading complex subunit TARBP2 (ECO:0000255 with HAMAP-Rule:MF_03034) TAR RNA-binding protein 2 Trans-activation-responsive RNA-binding protein
External Links
UniProt	Q15633
EMBL	M60801 U08998 BT007140 CH471054 BC005860 AF281068 AF281068
CCDS	CCDS41791.1 CCDS8861.1
PIR	G01420
RefSeq	NP_004169.3 NP_599150.1 NP_599151.2 XP_005269171.1 XP_005269172.1
UniGene	Hs.326 Hs.604255
PDB	2CPN 3ADL 3LLH
PDBsum	2CPN 3ADL 3LLH
ProteinModelPortal	Q15633
SMR	Q15633
BioGrid	112758
DIP	DIP-29665N
IntAct	Q15633
MINT	MINT-92451
STRING	9606.ENSP00000266987
PhosphoSite	Q15633
DMDM	209572714
MaxQB	Q15633
PaxDb	Q15633
PRIDE	Q15633
DNASU	6895
Ensembl	ENST00000266987 ENST00000394357 ENST00000456234
GeneID	6895
KEGG	hsa:6895
UCSC	uc001sdo.3
CTD	6895
GeneCards	GC12P053890
HGNC	HGNC:11569
HPA	HPA051181
MIM	605053
neXtProt	NX_Q15633
PharmGKB	PA36334
eggNOG	NOG245126
GeneTree	ENSGT00760000119275
HOGENOM	HOG000231919
HOVERGEN	HBG001700
InParanoid	Q15633
KO	K18420
OMA	SCTWDSL
PhylomeDB	Q15633
TreeFam	TF315953
Reactome	REACT_118560 REACT_12417
EvolutionaryTrace	Q15633
GeneWiki	TARBP2
GenomeRNAi	6895
NextBio	26949
PRO	PR:Q15633
Proteomes	UP000005640
Bgee	Q15633
CleanEx	HS_TARBP2
ExpressionAtlas	Q15633
Genevestigator	Q15633
GO	GO:0005737 GO:0005829 GO:0005634 GO:0048471 GO:0016442 GO:0003725 GO:0035198 GO:0042803 GO:0035197 GO:0010467 GO:0035280 GO:0050689 GO:0006469 GO:0045070 GO:0031054 GO:0030422 GO:0006357 GO:0006355 GO:0006417 GO:0046782 GO:0030423
Gene3D	3.30.160.20
HAMAP	MF_03034
InterPro	IPR014720 IPR028605
PANTHER	PTHR10910:SF61
Pfam	PF00035
SMART	SM00358
PROSITE	PS50137

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0035068	micro-ribonucleoprotein complex	PMID:17531811^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:17531811^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:23661684^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	PMID:23661684^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:19820710^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UPY3	F	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:19820710^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:16424907^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:25557550^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UPY3	F	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:16357216^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:16357216^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	PMID:18178619^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:18178619^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
contributes_to	GO:0070883	pre-miRNA binding	PMID:18178619^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:18178619^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:25608000^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	PMID:23435228^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:23661684^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:23661684^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:23661684^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050689	negative regulation of defense response to virus by host	PMID:11641396^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046782	regulation of viral transcription	PMID:11641396^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045070	positive regulation of viral genome replication	PMID:11641396^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17452327^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15633	F	Seeded From UniProt	complete
involved_in	GO:0035087	siRNA loading onto RISC involved in RNA interference	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:15973356^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:17452327^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:15973356^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17452327^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25416956^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15633	F	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0061351	neural precursor cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0051149	positive regulation of muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0043403	skeletal muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
part_of	GO:0035068	micro-ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	C	Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
involved_in	GO:0007286	spermatid development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97473 ensembl:ENSMUSP00000023813	P	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	F	Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	F	Seeded From UniProt	complete
involved_in	GO:0046782	regulation of viral transcription	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	P	Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	C	Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	F	Seeded From UniProt	complete
involved_in	GO:0090065	regulation of production of siRNA involved in RNA interference	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	P	Seeded From UniProt	complete
involved_in	GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028605	P	Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	P	Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	F	Seeded From UniProt	complete
enables	GO:0035198	miRNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	F	Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	C	Seeded From UniProt	complete
involved_in	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	P	Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106193	F	Seeded From UniProt	complete
enables	GO:0036002	pre-mRNA binding	PMID:19820710^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	PMID:11641396^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	Reactome:R-HSA-426486	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010586	miRNA metabolic process	Reactome:R-HSA-203927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-426464 Reactome:R-HSA-210805 Reactome:R-HSA-2106625 Reactome:R-HSA-2106615 Reactome:R-HSA-2106614 Reactome:R-HSA-203862	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Robb, GB & Rana, TM (2007) RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell 26 523-37 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lee, HY et al. (2013) Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41 6568-76 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Chendrimada, TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436 740-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Wang, HW et al. (2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol. 16 1148-53 PubMed GONUTS page
↑ Lee, Y et al. (2006) The role of PACT in the RNA silencing pathway. EMBO J. 25 522-32 PubMed GONUTS page
↑ Wilson, RC et al. (2015) Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol. Cell 57 397-407 PubMed GONUTS page
↑ ^7.0 ^7.1 Maniataki, E & Mourelatos, Z (2005) A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19 2979-90 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 MacRae, IJ et al. (2008) In vitro reconstitution of the human RISC-loading complex. Proc. Natl. Acad. Sci. U.S.A. 105 512-7 PubMed GONUTS page
↑ Acevedo, R et al. (2015) Helical defects in microRNA influence protein binding by TAR RNA binding protein. PLoS ONE 10 e0116749 PubMed GONUTS page
↑ Benoit, MP et al. (2013) The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains. Nucleic Acids Res. 41 4241-52 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Bannwarth, S et al. (2001) Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. J. Biol. Chem. 276 48803-13 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kok, KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282 17649-57 PubMed GONUTS page
↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

[PMID:17531811-1] 1.0 ^1.1 Robb, GB & Rana, TM (2007) RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell 26 523-37 PubMed GONUTS page

[PMID:23661684-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Lee, HY et al. (2013) Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41 6568-76 PubMed GONUTS page

[PMID:15973356-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Chendrimada, TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436 740-4 PubMed GONUTS page

[PMID:19820710-4] 4.0 ^4.1 ^4.2 Wang, HW et al. (2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol. 16 1148-53 PubMed GONUTS page

[PMID:16424907-5] Lee, Y et al. (2006) The role of PACT in the RNA silencing pathway. EMBO J. 25 522-32 PubMed GONUTS page

[PMID:25557550-6] Wilson, RC et al. (2015) Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol. Cell 57 397-407 PubMed GONUTS page

[PMID:16357216-7] 7.0 ^7.1 Maniataki, E & Mourelatos, Z (2005) A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19 2979-90 PubMed GONUTS page

[PMID:18178619-8] 8.0 ^8.1 ^8.2 ^8.3 MacRae, IJ et al. (2008) In vitro reconstitution of the human RISC-loading complex. Proc. Natl. Acad. Sci. U.S.A. 105 512-7 PubMed GONUTS page

[PMID:25608000-9] Acevedo, R et al. (2015) Helical defects in microRNA influence protein binding by TAR RNA binding protein. PLoS ONE 10 e0116749 PubMed GONUTS page

[PMID:23435228-10] Benoit, MP et al. (2013) The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains. Nucleic Acids Res. 41 4241-52 PubMed GONUTS page

[PMID:11641396-11] 11.0 ^11.1 ^11.2 ^11.3 Bannwarth, S et al. (2001) Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line. J. Biol. Chem. 276 48803-13 PubMed GONUTS page

[PMID:17452327-12] 12.0 ^12.1 ^12.2 Kok, KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282 17649-57 PubMed GONUTS page

[PMID:25416956-13] Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page

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HUMAN:TRBP2

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