HUMAN:DICER

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DICER1 (synonyms: DICER, HERNA, KIAA0928)
Protein Name(s)	Endoribonuclease Dicer Helicase with RNase motif Helicase MOI
External Links
UniProt	Q9UPY3
EMBL	AB028449 HM595745 AJ132261 AB023145 AK091513 AL356017 AL390254 CH471061 BC150287
CCDS	CCDS55941.1 CCDS9931.1
RefSeq	NP_001182502.1 NP_001258211.1 NP_001278557.1 NP_085124.2 NP_803187.1
UniGene	Hs.738957 Hs.87889
PDB	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA
PDBsum	2EB1 4NGB 4NGC 4NGD 4NGF 4NGG 4NH3 4NH5 4NH6 4NHA
ProteinModelPortal	Q9UPY3
SMR	Q9UPY3
BioGrid	116978
DIP	DIP-29664N
IntAct	Q9UPY3
MINT	MINT-1957525
STRING	9606.ENSP00000343745
ChEMBL	CHEMBL2311232
PhosphoSite	Q9UPY3
DMDM	257051056
MaxQB	Q9UPY3
PaxDb	Q9UPY3
PRIDE	Q9UPY3
Ensembl	ENST00000343455 ENST00000393063 ENST00000526495 ENST00000527414 ENST00000541352 ENST00000556045
GeneID	23405
KEGG	hsa:23405
UCSC	uc001ydv.3 uc001ydy.1 uc021sbc.1
CTD	23405
GeneCards	GC14M095552
HGNC	HGNC:17098
HPA	HPA000694
MIM	138800 180295 601200 606241
neXtProt	NX_Q9UPY3
Orphanet	276399 404476 99916 284343
PharmGKB	PA38437
eggNOG	COG1111
GeneTree	ENSGT00510000046789
HOGENOM	HOG000001567
HOVERGEN	HBG107811
InParanoid	Q9UPY3
KO	K11592
OMA	HSTIVPE
OrthoDB	EOG78PV82
PhylomeDB	Q9UPY3
TreeFam	TF330258
BRENDA	3.1.26.3
Reactome	REACT_118560 REACT_12417
ChiTaRS	DICER1
EvolutionaryTrace	Q9UPY3
GeneWiki	DICER1
GenomeRNAi	23405
NextBio	35469529
PRO	PR:Q9UPY3
Proteomes	UP000005640
Bgee	Q9UPY3
CleanEx	HS_DICER1
ExpressionAtlas	Q9UPY3
Genevestigator	Q9UPY3
GO	GO:0030424 GO:0005829 GO:0030425 GO:0005793 GO:0030426 GO:0016442 GO:0005524 GO:0003725 GO:0004386 GO:0046872 GO:0035198 GO:0004525 GO:0001525 GO:0048754 GO:0055013 GO:0021987 GO:0051607 GO:0035116 GO:0010467 GO:0071335 GO:0031069 GO:0060119 GO:0060576 GO:0030324 GO:0048255 GO:0035264 GO:0010626 GO:0000122 GO:0021675 GO:0048812 GO:0021889 GO:0032290 GO:0010628 GO:2000630 GO:0031643 GO:0014040 GO:0009791 GO:0031054 GO:0035196 GO:0030422 GO:0051726 GO:0070173 GO:0045664 GO:0048713 GO:0045069 GO:0048608 GO:0090501 GO:0090502 GO:0021522 GO:0051225 GO:0048536 GO:0019827 GO:0030423 GO:0010070
Gene3D	1.10.1520.10 3.30.160.20 3.40.50.300
InterPro	IPR011545 IPR005034 IPR014720 IPR014001 IPR001650 IPR027417 IPR003100 IPR000999
Pfam	PF00270 PF03368 PF00271 PF02170 PF00636
SMART	SM00487 SM00358 SM00490 SM00949 SM00535
SUPFAM	SSF101690 SSF52540 SSF69065
PROSITE	PS51327 PS50137 PS51192 PS51194 PS50821 PS00517 PS50142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:26435691^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:26435691^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(RNAcentral:URS0000315338_9606) part_of:(GO:0038061)\|has_input(RNAcentral:URS0000209905_9606) part_of:(GO:0038061)	Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	PMID:26435691^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035148	tube formation	PMID:23322395^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008) has_agent:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:23322395^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000143590) occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:23322395^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_output:(RNAcentral:URS000055128B_9606) occurs_in:(CL:2000008)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:28159509^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0002409)\|part_of:(UBERON:0001969)	Seeded From UniProt	complete
part_of	GO:0035068	micro-ribonucleoprotein complex	PMID:17531811^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:17531811^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:23661684^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:19820710^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035087	siRNA loading onto RISC involved in RNA interference	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:12526743^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UL18	F		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:23661684^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|part_of	GO:0016442	RISC complex	PMID:16357216^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:16357216^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:16357216^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	PMID:18178619^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:18178619^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
contributes_to	GO:0070883	pre-miRNA binding	PMID:18178619^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:18178619^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033167	ARC complex	PMID:19701182^[11]	ECO:0000305	curator inference used in manual assertion	GO:0003725 GO:0004521 GO:0033168	C		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:19701182^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:19701182^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033168	conversion of ds siRNA to ss siRNA involved in RNA interference	PMID:19701182^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(RNAcentral:URS000075C8FA_9606)	Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	PMID:18508075^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	PMID:21753850^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:21753850^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	PMID:25549615^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:25549615^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	PMID:25549615^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	PMID:23661684^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:23661684^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:25549615^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G034	P		Seeded From UniProt	complete
involved_in	GO:0032290	peripheral nervous system myelin formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G034	P		Seeded From UniProt	complete
involved_in	GO:0031643	positive regulation of myelination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G034	P		Seeded From UniProt	complete
involved_in	GO:0014040	positive regulation of Schwann cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0010626	negative regulation of Schwann cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q4G034	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R418	P		Seeded From UniProt	complete
involved_in	GO:0036404	conversion of ds siRNA to ss siRNA	PMID:18325616^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:18325616^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:17452327^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	PMID:15973356^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:17452327^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	PMID:15973356^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	PMID:12411504^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN001029377 UniProtKB:Q9UPY3 WB:WBGene00000939	P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c UniProtKB:Q9LXW7 UniProtKB:Q9UPY3 WB:WBGene00000939	P		Seeded From UniProt	complete
part_of	GO:0016442	RISC complex	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 UniProtKB:Q9UPY3	C		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 MGI:MGI:2177178 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 WB:WBGene00000939	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 FB:FBgn0039016 PANTHER:PTN000383724 PomBase:SPCC188.13c TAIR:locus:2092409 UniProtKB:P84634 UniProtKB:Q9LXW7 UniProtKB:Q9SP32 WB:WBGene00000939	C		Seeded From UniProt	complete
enables	GO:0004530	deoxyribonuclease I activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001029377 WB:WBGene00000939	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:21873635^[18]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0034246 MGI:MGI:2177178 PANTHER:PTN000383724 TAIR:locus:2092409 UniProtKB:Q9UPY3 WB:WBGene00000939	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:12411505^[19]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:12411504^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:11452083^[20]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	PMID:11201747^[21]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PU15 ensembl:ENSRNOP00000014405	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PU15 ensembl:ENSRNOP00000014405	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PU15 ensembl:ENSRNOP00000014405	C		Seeded From UniProt	complete
part_of	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PU15 ensembl:ENSRNOP00000014405	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005034	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.26.3	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	PMID:19820710^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	Reactome:R-HSA-426486	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010586	miRNA metabolic process	Reactome:R-HSA-203927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-426464 Reactome:R-HSA-210805 Reactome:R-HSA-2106625 Reactome:R-HSA-2106615 Reactome:R-HSA-2106614 Reactome:R-HSA-203862	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Guan, Y et al. (2015) NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress. Int. J. Biol. Sci. 11 1257-68 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Xiao, F et al. (2013) WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology 23 524-35 PubMed GONUTS page
↑ Beltrami, C et al. (2017) Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. Mol. Ther. 25 679-693 PubMed GONUTS page
↑ ^4.0 ^4.1 Robb, GB & Rana, TM (2007) RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell 26 523-37 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Lee, HY et al. (2013) Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41 6568-76 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Chendrimada, TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436 740-4 PubMed GONUTS page
↑ ^7.0 ^7.1 Wang, HW et al. (2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol. 16 1148-53 PubMed GONUTS page
↑ Doi, N et al. (2003) Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr. Biol. 13 41-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Maniataki, E & Mourelatos, Z (2005) A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19 2979-90 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 MacRae, IJ et al. (2008) In vitro reconstitution of the human RISC-loading complex. Proc. Natl. Acad. Sci. U.S.A. 105 512-7 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Maida, Y et al. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 461 230-5 PubMed GONUTS page
↑ Ma, E et al. (2008) Autoinhibition of human dicer by its internal helicase domain. J. Mol. Biol. 380 237-43 PubMed GONUTS page
↑ ^13.0 ^13.1 Park, JE et al. (2011) Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature 475 201-5 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Liu, Z et al. (2015) Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain. Protein Cell 6 185-93 PubMed GONUTS page
↑ ^15.0 ^15.1 Chen, W et al. (2008) HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res. 133 250-8 PubMed GONUTS page
↑ ^16.0 ^16.1 Kok, KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282 17649-57 PubMed GONUTS page
↑ ^17.0 ^17.1 Provost, P et al. (2002) Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J. 21 5864-74 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhang, H et al. (2002) Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21 5875-85 PubMed GONUTS page
↑ Hutvágner, G et al. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293 834-8 PubMed GONUTS page
↑ Bernstein, E et al. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 363-6 PubMed GONUTS page

[PMID:26435691-1] 1.0 ^1.1 ^1.2 Guan, Y et al. (2015) NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress. Int. J. Biol. Sci. 11 1257-68 PubMed GONUTS page

[PMID:23322395-2] 2.0 ^2.1 ^2.2 Xiao, F et al. (2013) WSS25 inhibits Dicer, downregulating microRNA-210, which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology 23 524-35 PubMed GONUTS page

[PMID:28159509-3] Beltrami, C et al. (2017) Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. Mol. Ther. 25 679-693 PubMed GONUTS page

[PMID:17531811-4] 4.0 ^4.1 Robb, GB & Rana, TM (2007) RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell 26 523-37 PubMed GONUTS page

[PMID:23661684-5] 5.0 ^5.1 ^5.2 ^5.3 Lee, HY et al. (2013) Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 41 6568-76 PubMed GONUTS page

[PMID:15973356-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Chendrimada, TP et al. (2005) TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436 740-4 PubMed GONUTS page

[PMID:19820710-7] 7.0 ^7.1 Wang, HW et al. (2009) Structural insights into RNA processing by the human RISC-loading complex. Nat. Struct. Mol. Biol. 16 1148-53 PubMed GONUTS page

[PMID:12526743-8] Doi, N et al. (2003) Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr. Biol. 13 41-6 PubMed GONUTS page

[PMID:16357216-9] 9.0 ^9.1 ^9.2 Maniataki, E & Mourelatos, Z (2005) A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19 2979-90 PubMed GONUTS page

[PMID:18178619-10] 10.0 ^10.1 ^10.2 ^10.3 MacRae, IJ et al. (2008) In vitro reconstitution of the human RISC-loading complex. Proc. Natl. Acad. Sci. U.S.A. 105 512-7 PubMed GONUTS page

[PMID:19701182-11] 11.0 ^11.1 ^11.2 ^11.3 Maida, Y et al. (2009) An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature 461 230-5 PubMed GONUTS page

[PMID:18508075-12] Ma, E et al. (2008) Autoinhibition of human dicer by its internal helicase domain. J. Mol. Biol. 380 237-43 PubMed GONUTS page

[PMID:21753850-13] 13.0 ^13.1 Park, JE et al. (2011) Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature 475 201-5 PubMed GONUTS page

[PMID:25549615-14] 14.0 ^14.1 ^14.2 ^14.3 Liu, Z et al. (2015) Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain. Protein Cell 6 185-93 PubMed GONUTS page

[PMID:18325616-15] 15.0 ^15.1 Chen, W et al. (2008) HCV core protein interacts with Dicer to antagonize RNA silencing. Virus Res. 133 250-8 PubMed GONUTS page

[PMID:17452327-16] 16.0 ^16.1 Kok, KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J. Biol. Chem. 282 17649-57 PubMed GONUTS page

[PMID:12411504-17] 17.0 ^17.1 Provost, P et al. (2002) Ribonuclease activity and RNA binding of recombinant human Dicer. EMBO J. 21 5864-74 PubMed GONUTS page

[PMID:21873635-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12411505-19] Zhang, H et al. (2002) Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP. EMBO J. 21 5875-85 PubMed GONUTS page

[PMID:11452083-20] Hutvágner, G et al. (2001) A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293 834-8 PubMed GONUTS page

[PMID:11201747-21] Bernstein, E et al. (2001) Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409 363-6 PubMed GONUTS page

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