HUMAN:TTP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ZFP36 (synonyms: G0S24, RNF162A, TIS11A, TTP)
Protein Name(s)	Tristetraprolin TTP G0/G1 switch regulatory protein 24 Growth factor-inducible nuclear protein NUP475 Protein TIS11A TIS11 Zinc finger protein 36 homolog Zfp-36
External Links
UniProt	P26651
EMBL	M92843 M92844 M63625 AK314042 AY771351 BC009693
PIR	S34427
RefSeq	NP_003398.2
UniGene	Hs.534052
PDB	4J8S
PDBsum	4J8S
ProteinModelPortal	P26651
SMR	P26651
BioGrid	113370
DIP	DIP-29845N
IntAct	P26651
MINT	MINT-1171915
STRING	9606.ENSP00000248673
PhosphoSite	P26651
DMDM	136471
PaxDb	P26651
PRIDE	P26651
DNASU	7538
Ensembl	ENST00000248673
GeneID	7538
KEGG	hsa:7538
UCSC	uc002olh.2
CTD	7538
GeneCards	GC19P039897
HGNC	HGNC:12862
HPA	HPA006009
MIM	190700
neXtProt	NX_P26651
PharmGKB	PA37451
eggNOG	COG5063
HOGENOM	HOG000233479
HOVERGEN	HBG008483
InParanoid	P26651
KO	K15308
OrthoDB	EOG76QFJP
PhylomeDB	P26651
TreeFam	TF315463
Reactome	REACT_25064
SignaLink	P26651
ChiTaRS	ZFP36
GeneWiki	ZFP36
GenomeRNAi	7538
NextBio	29497
PRO	PR:P26651
Proteomes	UP000005640
Bgee	P26651
CleanEx	HS_ZFP36
ExpressionAtlas	P26651
Genevestigator	P26651
GO	GO:0005737 GO:0010494 GO:0005829 GO:0005634 GO:0071889 GO:0017091 GO:0019957 GO:0003677 GO:0046872 GO:0035925 GO:0003729 GO:0044822 GO:0019901 GO:0003727 GO:0070935 GO:0010467 GO:0035556 GO:0006402 GO:0016071 GO:0050728 GO:0045638 GO:0000122 GO:0035278 GO:0000288 GO:0000289 GO:1900153 GO:0060213 GO:0032680 GO:0042594 GO:0050779 GO:0016070
Gene3D	4.10.1000.10
InterPro	IPR000571
Pfam	PF00642
SMART	SM00356
PROSITE	PS50103

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:11719186^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:11719186^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|colocalizes_with	GO:0000178	exosome (RNase complex)	PMID:11719186^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:14679154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:14679154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032897	negative regulation of viral transcription	PMID:14679154^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
involved_in	GO:1901835	positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA	PMID:16364915^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0098745	Dcp1-Dcp2 complex	PMID:16364915^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:21964062^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:21964062^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031072	heat shock protein binding	PMID:20221403^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20221403^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:20221403^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:20221403^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:20221403^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:15187101^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:15187101^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:15187101^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:15187101^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:15187101^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:9703499^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:9703499^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:9703499^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12198173^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12198173^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:27193233^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:20166898^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:20166898^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	PMID:20166898^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	PMID:20166898^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071385	cellular response to glucocorticoid stimulus	PMID:20166898^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045085	negative regulation of interleukin-2 biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:15634918^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:15634918^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15634918^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:15634918^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:15687258^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:15687258^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:15687258^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:15687258^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14679154^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14679154^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902172	regulation of keratinocyte apoptotic process	PMID:27182009^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045616	regulation of keratinocyte differentiation	PMID:27182009^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010837	regulation of keratinocyte proliferation	PMID:27182009^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	PMID:27182009^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:17369404^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	PMID:17369404^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904582	positive regulation of intracellular mRNA localization	PMID:17369404^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	PMID:20702587^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:20702587^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:20702587^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045647	negative regulation of erythrocyte differentiation	PMID:20702587^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
part_of	GO:1990904	ribonucleoprotein complex	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:14766228^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14766228^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030014	CCR4-NOT complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	C		Seeded From UniProt	complete
involved_in	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay	PMID:11279239^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070063	RNA polymerase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	F		Seeded From UniProt	complete
involved_in	GO:2000637	positive regulation of gene silencing by miRNA	PMID:15766526^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:15766526^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0070578	RISC-loading complex	PMID:15766526^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:15766526^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904246	negative regulation of polynucleotide adenylyltransferase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
involved_in	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	PMID:23644599^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:25038453^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UIV1	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:25038453^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:A5YKK6	F		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:25038453^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000090339)\|has_direct_input:(ENSEMBL:ENSG00000169429)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25038453^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	PMID:12748283^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:12748283^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070935	3'-UTR-mediated mRNA stabilization	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[24]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035278	miRNA mediated inhibition of translation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P22893	P		Seeded From UniProt	complete
involved_in	GO:0032680	regulation of tumor necrosis factor production	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019957	C-C chemokine binding	PMID:21784977^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10147	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15014438^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P49137	F		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:21784977^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:15014438^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21784977^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10330172^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	PMID:23644599^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21784977^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10147)	Seeded From UniProt	complete
involved_in	GO:0061158	3'-UTR-mediated mRNA destabilization	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011837 MGI:MGI:107945 MGI:MGI:107946 MGI:MGI:99180 PANTHER:PTN001756332 UniProtKB:P26651 UniProtKB:P47974 UniProtKB:Q07352	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99180 PANTHER:PTN001756332 RGD:62009 UniProtKB:P26651 WB:WBGene00004027	C		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011837 PANTHER:PTN001756332 RGD:620722 WB:WBGene00003230 WB:WBGene00003231 WB:WBGene00003864 WB:WBGene00004078	F		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:11782475^[27]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:10751406^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10751406^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:11782475^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000571 InterPro:IPR036855	F		Seeded From UniProt	complete
involved_in	GO:0006402	mRNA catabolic process	PMID:9703499^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9703499^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035925	mRNA 3'-UTR AU-rich region binding	PMID:9703499^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043488	regulation of mRNA stability	Reactome:R-HSA-450513	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-450463 Reactome:R-HSA-450431 Reactome:R-HSA-450400 Reactome:R-HSA-450394	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Chen, CY et al. (2001) AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 107 451-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Twizere, JC et al. (2003) Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. J. Natl. Cancer Inst. 95 1846-59 PubMed GONUTS page
↑ ^3.0 ^3.1 Fenger-Grøn, M et al. (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20 905-15 PubMed GONUTS page
↑ ^4.0 ^4.1 Holmes, B et al. (2012) Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cell. Signal. 24 309-15 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kedar, VP et al. (2010) Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. PLoS ONE 5 e9588 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Brooks, SA et al. (2004) The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. J. Immunol. 172 7263-71 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Carballo, E et al. (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281 1001-5 PubMed GONUTS page
↑ ^8.0 ^8.1 Stoecklin, G et al. (2002) Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J. 21 4709-18 PubMed GONUTS page
↑ Nowotarski, SL et al. (2016) Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Amino Acids 48 2303-11 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Hacker, C et al. (2010) ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. Growth Factors 28 178-90 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Ogilvie, RL et al. (2005) Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J. Immunol. 174 953-61 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Lykke-Andersen, J & Wagner, E (2005) Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 19 351-61 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Prenzler, F et al. (2016) Functional analysis of ZFP36 proteins in keratinocytes. Eur. J. Cell Biol. 95 277-84 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Franks, TM & Lykke-Andersen, J (2007) TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 21 719-35 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Vignudelli, T et al. (2010) ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. Mol. Biol. Cell 21 3340-51 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Lai, WS et al. (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell. Biol. 19 4311-23 PubMed GONUTS page
↑ ^17.0 ^17.1 Carman, JA & Nadler, SG (2004) Direct association of tristetraprolin with the nucleoporin CAN/Nup214. Biochem. Biophys. Res. Commun. 315 445-9 PubMed GONUTS page
↑ Lai, WS & Blackshear, PJ (2001) Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J. Biol. Chem. 276 23144-54 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Jing, Q et al. (2005) Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 120 623-34 PubMed GONUTS page
↑ ^20.0 ^20.1 Fabian, MR et al. (2013) Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat. Struct. Mol. Biol. 20 735-9 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Shi, JX et al. (2014) CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin. Cell. Signal. 26 2390-6 PubMed GONUTS page
↑ ^22.0 ^22.1 Lai, WS et al. (2003) Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol. Cell. Biol. 23 3798-812 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Stoecklin, G et al. (2004) MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 23 1313-24 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Kang, JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J. Immunol. 187 2696-701 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^27.0 ^27.1 Lai, WS et al. (2002) Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J. Biol. Chem. 277 9606-13 PubMed GONUTS page
↑ ^28.0 ^28.1 Lai, WS et al. (2000) Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J. Biol. Chem. 275 17827-37 PubMed GONUTS page

[PMID:11719186-1] 1.0 ^1.1 ^1.2 Chen, CY et al. (2001) AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 107 451-64 PubMed GONUTS page

[PMID:14679154-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Twizere, JC et al. (2003) Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. J. Natl. Cancer Inst. 95 1846-59 PubMed GONUTS page

[PMID:16364915-3] 3.0 ^3.1 Fenger-Grøn, M et al. (2005) Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol. Cell 20 905-15 PubMed GONUTS page

[PMID:21964062-4] 4.0 ^4.1 Holmes, B et al. (2012) Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cell. Signal. 24 309-15 PubMed GONUTS page

[PMID:20221403-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Kedar, VP et al. (2010) Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85. PLoS ONE 5 e9588 PubMed GONUTS page

[PMID:15187101-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Brooks, SA et al. (2004) The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. J. Immunol. 172 7263-71 PubMed GONUTS page

[PMID:9703499-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Carballo, E et al. (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281 1001-5 PubMed GONUTS page

[PMID:12198173-8] 8.0 ^8.1 Stoecklin, G et al. (2002) Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J. 21 4709-18 PubMed GONUTS page

[PMID:27193233-9] Nowotarski, SL et al. (2016) Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Amino Acids 48 2303-11 PubMed GONUTS page

[PMID:20166898-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Hacker, C et al. (2010) ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. Growth Factors 28 178-90 PubMed GONUTS page

[PMID:15634918-11] 11.0 ^11.1 ^11.2 ^11.3 Ogilvie, RL et al. (2005) Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J. Immunol. 174 953-61 PubMed GONUTS page

[PMID:15687258-12] 12.0 ^12.1 ^12.2 ^12.3 Lykke-Andersen, J & Wagner, E (2005) Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev. 19 351-61 PubMed GONUTS page

[PMID:27182009-13] 13.0 ^13.1 ^13.2 ^13.3 Prenzler, F et al. (2016) Functional analysis of ZFP36 proteins in keratinocytes. Eur. J. Cell Biol. 95 277-84 PubMed GONUTS page

[PMID:17369404-14] 14.0 ^14.1 ^14.2 Franks, TM & Lykke-Andersen, J (2007) TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev. 21 719-35 PubMed GONUTS page

[PMID:20702587-15] 15.0 ^15.1 ^15.2 ^15.3 Vignudelli, T et al. (2010) ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. Mol. Biol. Cell 21 3340-51 PubMed GONUTS page

[PMID:10330172-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Lai, WS et al. (1999) Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell. Biol. 19 4311-23 PubMed GONUTS page

[PMID:14766228-17] 17.0 ^17.1 Carman, JA & Nadler, SG (2004) Direct association of tristetraprolin with the nucleoporin CAN/Nup214. Biochem. Biophys. Res. Commun. 315 445-9 PubMed GONUTS page

[PMID:11279239-18] Lai, WS & Blackshear, PJ (2001) Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J. Biol. Chem. 276 23144-54 PubMed GONUTS page

[PMID:15766526-19] 19.0 ^19.1 ^19.2 ^19.3 Jing, Q et al. (2005) Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 120 623-34 PubMed GONUTS page

[PMID:23644599-20] 20.0 ^20.1 Fabian, MR et al. (2013) Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nat. Struct. Mol. Biol. 20 735-9 PubMed GONUTS page

[PMID:25038453-21] 21.0 ^21.1 ^21.2 ^21.3 Shi, JX et al. (2014) CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin. Cell. Signal. 26 2390-6 PubMed GONUTS page

[PMID:12748283-22] 22.0 ^22.1 Lai, WS et al. (2003) Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol. Cell. Biol. 23 3798-812 PubMed GONUTS page

[PMID:15014438-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Stoecklin, G et al. (2004) MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 23 1313-24 PubMed GONUTS page

[PMID:22658674-24] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:21784977-25] 25.0 ^25.1 ^25.2 ^25.3 Kang, JG et al. (2011) Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation. J. Immunol. 187 2696-701 PubMed GONUTS page

[PMID:21873635-26] 26.0 ^26.1 ^26.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11782475-27] 27.0 ^27.1 Lai, WS et al. (2002) Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J. Biol. Chem. 277 9606-13 PubMed GONUTS page

[PMID:10751406-28] 28.0 ^28.1 Lai, WS et al. (2000) Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J. Biol. Chem. 275 17827-37 PubMed GONUTS page

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