CRIGR:DICER

Species (Taxon ID)	Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). (10029)
Gene Name(s)	DICER1 (synonyms: DICER)
Protein Name(s)	Endoribonuclease Dicer
External Links
UniProt	A0MQH0
EMBL	EF031271
RefSeq	NP_001231198.1 XP_007647243.1 XP_007647244.1
ProteinModelPortal	A0MQH0
SMR	A0MQH0
GeneID	100689239
KEGG	cge:100689239
CTD	23405
KO	K11592
GO	GO:0005737 GO:0016442 GO:0005524 GO:0004386 GO:0046872 GO:0004525 GO:0003723 GO:0031054 GO:0030422 GO:0030423
Gene3D	1.10.1520.10 3.30.160.20 3.40.50.300
InterPro	IPR011545 IPR005034 IPR014720 IPR014001 IPR001650 IPR027417 IPR003100 IPR000999
Pfam	PF00270 PF03368 PF00271 PF02170 PF00636
SMART	SM00487 SM00358 SM00490 SM00949 SM00535
SUPFAM	SSF101690 SSF52540 SSF69065
PROSITE	PS51327 PS50137 PS51192 PS51194 PS50821 PS00517 PS50142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0035068	micro-ribonucleoprotein complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UPY3	C		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UPY3	P		Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UPY3	P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UPY3	P		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9UPY3	C		Seeded From UniProt	complete
involved_in	GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
enables	GO:0070883	pre-miRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
part_of	GO:0070578	RISC-loading complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	C		Seeded From UniProt	complete
involved_in	GO:0038061	NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0036404	conversion of ds siRNA to ss siRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
involved_in	GO:0035196	production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0035087	siRNA loading onto RISC involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
part_of	GO:0035068	micro-ribonucleoprotein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	C		Seeded From UniProt	complete
involved_in	GO:0033168	conversion of ds siRNA to ss siRNA involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0031054	pre-miRNA processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0030423	targeting of mRNA for destruction involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
involved_in	GO:0030422	production of siRNA involved in RNA interference	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
enables	GO:0004521	endoribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
enables	GO:0003725	double-stranded RNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UPY3 ensembl:ENSP00000437256	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
involved_in	GO:0006396	RNA processing	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000999 InterPro:IPR036389	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006935	F		Seeded From UniProt	complete
enables	GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005034	F		Seeded From UniProt	complete
enables	GO:0004525	ribonuclease III activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.26.3	F		Seeded From UniProt	complete
enables	GO:0004519	endonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0255	F		Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0031047	gene silencing by RNA	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0943	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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References

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