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ARATH:DCL4

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Species (Taxon ID) Arabidopsis thaliana (Mouse-ear cress). (3702)
Gene Name(s) DCL4
Protein Name(s) Dicer-like protein 4
External Links
UniProt P84634
EMBL DQ118423
AF296825
CP002688
RefSeq NP_197532.3
UniGene At.31201
PDB 2KOU
PDBsum 2KOU
ProteinModelPortal P84634
SMR P84634
BioGrid 17430
IntAct P84634
MINT MINT-6948367
STRING 3702.AT5G20320.1-P
PaxDb P84634
PRIDE P84634
EnsemblPlants AT5G20320.1
GeneID 832154
KEGG ath:AT5G20320
TAIR AT5G20320
eggNOG COG1111
HOGENOM HOG000083706
InParanoid P84634
KO K11592
OMA EPTQFFA
PhylomeDB P84634
BioCyc ARA:AT5G20320-MONOMER
ARA:GQT-2073-MONOMER
EvolutionaryTrace P84634
Proteomes UP000006548
Genevestigator P84634
GO GO:0005634
GO:0005524
GO:0004386
GO:0046872
GO:0004525
GO:0003723
GO:0051607
GO:0006353
GO:0010216
GO:0010599
GO:0030422
GO:0010267
GO:0010050
GO:0009616
Gene3D 1.10.1520.10
3.30.160.20
3.40.50.300
InterPro IPR011545
IPR005034
IPR014720
IPR014001
IPR001650
IPR027417
IPR003100
IPR000999
Pfam PF00270
PF03368
PF00271
PF02170
PF00636
SMART SM00487
SM00358
SM00490
SM00949
SM00535
SUPFAM SSF52540
SSF69065
PROSITE PS51327
PS50137
PS51192
PS51194
PS50821
PS00517
PS50142

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0009616

virus induced gene silencing

PMID:17090584[1]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT3G49500
AGI_LocusCode:AT4G20910

P

Seeded From UniProt

complete

involved_in

GO:0006353

DNA-templated transcription, termination

PMID:22461611[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15821876[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:26023161[4]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT3G03300
AGI_LocusCode:AT3G43920

P

Seeded From UniProt

complete

involved_in

GO:0051214

RNA virus induced gene silencing

PMID:25385769[5]

ECO:0000316

genetic interaction evidence used in manual assertion

AGI_LocusCode:AT3G03300
AGI_LocusCode:AT3G43920

P

Seeded From UniProt

complete

involved_in

GO:0010599

production of lsiRNA involved in RNA interference

PMID:18003861[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010267

production of ta-siRNAs involved in RNA interference

PMID:16699516[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010267

production of ta-siRNAs involved in RNA interference

PMID:16129836[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010216

maintenance of DNA methylation

PMID:16699516[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010050

vegetative phase change

PMID:16129836[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030422

production of siRNA involved in RNA interference

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034246
FB:FBgn0039016
MGI:MGI:2177178
PANTHER:PTN000383724
PomBase:SPCC188.13c
UniProtKB:Q9LXW7
UniProtKB:Q9UPY3
WB:WBGene00000939

P

Seeded From UniProt

complete

part_of

GO:0016442

RISC complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034246
FB:FBgn0039016
PANTHER:PTN000383724
UniProtKB:Q9UPY3

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034246
FB:FBgn0039016
MGI:MGI:2177178
PANTHER:PTN000383724
PomBase:SPCC188.13c
TAIR:locus:2092409
WB:WBGene00000939

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034246
FB:FBgn0039016
PANTHER:PTN000383724
PomBase:SPCC188.13c
TAIR:locus:2092409
UniProtKB:P84634
UniProtKB:Q9LXW7
UniProtKB:Q9SP32
WB:WBGene00000939

C

Seeded From UniProt

complete

enables

GO:0004525

ribonuclease III activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0034246
MGI:MGI:2177178
PANTHER:PTN000383724
TAIR:locus:2092409
UniProtKB:Q9UPY3
WB:WBGene00000939

F

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004519

P

Seeded From UniProt

complete

involved_in

GO:0090305

nucleic acid phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004518

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

GO:0009616

virus induced gene silencing

PMID:20190077[10]

ECO:0000315

P

Figure 5.A. (right) shows that only mutants lacking DCL4 (dcl4, dcl2/dcl4, dcl3/dcl4, and dcl2/dcl3/dcl4), when infected with TuMV-AS9-GFP (which lacks a silencing suppressor), have infection levels comparable to when infected with TuMV-GFP.

complete
CACAO 8200

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0016891

P

Seeded From UniProt

complete

involved_in

GO:0090502

RNA phosphodiester bond hydrolysis, endonucleolytic

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004525

P

Seeded From UniProt

complete

involved_in

GO:0048608

reproductive structure development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A7LFZ6
RAP2018-11-26:Os04t0509300-02

P

Seeded From UniProt

complete

involved_in

GO:0010492

maintenance of shoot apical meristem identity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A7LFZ6
RAP2018-11-26:Os04t0509300-02

P

Seeded From UniProt

complete

involved_in

GO:0010267

production of ta-siRNAs involved in RNA interference

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A7LFZ6
RAP2018-11-26:Os04t0509300-02

P

Seeded From UniProt

complete

involved_in

GO:0009944

polarity specification of adaxial/abaxial axis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:A7LFZ6
RAP2018-11-26:Os04t0509300-02

P

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011545

F

Seeded From UniProt

complete

enables

GO:0004525

ribonuclease III activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000999
InterPro:IPR036389

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011545

F

Seeded From UniProt

complete

involved_in

GO:0006396

RNA processing

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000999
InterPro:IPR036389

P

Seeded From UniProt

complete

enables

GO:0016891

endoribonuclease activity, producing 5'-phosphomonoesters

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005034

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0004519

endonuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0255

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0611

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0031047

gene silencing by RNA

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0943

P

Seeded From UniProt

complete

enables

GO:0004518

nuclease activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0540

F

Seeded From UniProt

complete

enables

GO:0004386

helicase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Blevins, T et al. (2006) Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing. Nucleic Acids Res. 34 6233-46 PubMed GONUTS page
  2. ↑ Liu, F et al. (2012) Cotranscriptional role for Arabidopsis DICER-LIKE 4 in transcription termination. Science 335 1621-3 PubMed GONUTS page
  3. ↑ Hiraguri, A et al. (2005) Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana. Plant Mol. Biol. 57 173-88 PubMed GONUTS page
  4. ↑ Brosseau, C & Moffett, P (2015) Functional and Genetic Analysis Identify a Role for Arabidopsis ARGONAUTE5 in Antiviral RNA Silencing. Plant Cell 27 1742-54 PubMed GONUTS page
  5. ↑ Ma, X et al. (2015) Different roles for RNA silencing and RNA processing components in virus recovery and virus-induced gene silencing in plants. J. Exp. Bot. 66 919-32 PubMed GONUTS page
  6. ↑ Katiyar-Agarwal, S et al. (2007) A novel class of bacteria-induced small RNAs in Arabidopsis. Genes Dev. 21 3123-34 PubMed GONUTS page
  7. ↑ 7.0 7.1 Henderson, IR et al. (2006) Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning. Nat. Genet. 38 721-5 PubMed GONUTS page
  8. ↑ 8.0 8.1 Xie, Z et al. (2005) DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 102 12984-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 9.3 9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. ↑ Garcia-Ruiz, H et al. (2010) Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip Mosaic Virus infection. Plant Cell 22 481-96 PubMed GONUTS page
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