YEAST:NU170

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	NUP170 (synonyms: NLE3)
Protein Name(s)	Nucleoporin NUP170 Nuclear pore protein NUP170
External Links
UniProt	P38181
EMBL	X79489 Z35840 BK006936
PIR	S45429
RefSeq	NP_009474.1
PDB	3I5P 3I5Q
PDBsum	3I5P 3I5Q
ProteinModelPortal	P38181
SMR	P38181
BioGrid	32624
DIP	DIP-2450N
IntAct	P38181
MINT	MINT-2788627
STRING	4932.YBL079W
TCDB	1.I.1.1.1
MaxQB	P38181
PaxDb	P38181
PeptideAtlas	P38181
EnsemblFungi	[example_ID YBL079W]
GeneID	852199
KEGG	sce:YBL079W
CYGD	YBL079w
SGD	S000000175
eggNOG	COG5308
GeneTree	ENSGT00390000016532
HOGENOM	HOG000246581
InParanoid	P38181
KO	K14312
OMA	DWFNSKC
OrthoDB	EOG7GXPKT
BioCyc	YEAST:G3O-28970-MONOMER
EvolutionaryTrace	P38181
NextBio	970691
Proteomes	UP000002311
Genevestigator	P38181
GO	GO:0031965 GO:0005643 GO:0044611 GO:0017056 GO:0007059 GO:0070869 GO:0051028 GO:0051292 GO:0006913 GO:0036228
InterPro	IPR007187 IPR014908 IPR004870
PANTHER	PTHR10350
Pfam	PF03177 PF08801

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016584	nucleosome positioning	PMID:23452847^[1]	ECO:0000315			P		Figure 4 shows loss of Nup170p alters nucleosome positioning compared to wild type.	complete CACAO 6827
	GO:0016458	gene silencing	PMID:23452847^[1]	ECO:0000315			P		Figure 3 shows Nup170p is required for subtelomeric gene silencing.	complete CACAO 6828
involved_in	GO:0034398	telomere tethering at nuclear periphery	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:23452847^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(GO:0016586)	Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:23452847^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0001997)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_at:(SO:0001997)	Seeded From UniProt	complete
involved_in	GO:0016584	nucleosome positioning	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_at:(SO:0001997)	Seeded From UniProt	complete
involved_in	GO:0016458	gene silencing	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016584	nucleosome positioning	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070869	heterochromatin assembly involved in chromatin silencing	PMID:23452847^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051292	nuclear pore complex assembly	PMID:20498018^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003946	P		Seeded From UniProt	complete
involved_in	GO:0051292	nuclear pore complex assembly	PMID:19414608^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000907	P		Seeded From UniProt	complete
part_of	GO:0044611	nuclear pore inner ring	PMID:18046406^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036228	protein localization to nuclear inner membrane	PMID:21659568^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036228	protein localization to nuclear inner membrane	PMID:16929305^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:19414608^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000907	F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:20498018^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003946	F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:19414606^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:12509452^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:17418788^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007059	chromosome segregation	PMID:11290711^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	PMID:10684247^[11]	ECO:0000305	curator inference used in manual assertion	GO:0005643	P		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	PMID:10684247^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044611	nuclear pore inner ring	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000039103 SGD:S000000175 SGD:S000000907	C		Seeded From UniProt	complete
involved_in	GO:0036228	protein localization to nuclear inner membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0021761 PANTHER:PTN000039103 SGD:S000000175	P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000039103 SGD:S000000175 SGD:S000000907	F		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2181182 PANTHER:PTN000039103	P		Seeded From UniProt	complete
involved_in	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000039103 SGD:S000000907	P		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004870	C		Seeded From UniProt	complete
involved_in	GO:0006913	nucleocytoplasmic transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004870	P		Seeded From UniProt	complete
enables	GO:0017056	structural constituent of nuclear pore	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004870	F		Seeded From UniProt	complete
involved_in	GO:0051028	mRNA transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0509	P		Seeded From UniProt	complete
part_of	GO:0005643	nuclear pore	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0906 UniProtKB-SubCell:SL-0185	C		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653 UniProtKB-KW:KW-0811	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Van de Vosse, DW et al. (2013) A role for the nucleoporin Nup170p in chromatin structure and gene silencing. Cell 152 969-83 PubMed GONUTS page
↑ ^2.0 ^2.1 Chadrin, A et al. (2010) Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J. Cell Biol. 189 795-811 PubMed GONUTS page
↑ ^3.0 ^3.1 Makio, T et al. (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J. Cell Biol. 185 459-73 PubMed GONUTS page
↑ Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page
↑ Meinema, AC et al. (2011) Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science 333 90-3 PubMed GONUTS page
↑ King, MC et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442 1003-7 PubMed GONUTS page
↑ Flemming, D et al. (2009) Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores. J. Cell Biol. 185 387-95 PubMed GONUTS page
↑ Shulga, N & Goldfarb, DS (2003) Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating. Mol. Cell. Biol. 23 534-42 PubMed GONUTS page
↑ Patel, SS et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129 83-96 PubMed GONUTS page
↑ Kerscher, O et al. (2001) Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157 1543-53 PubMed GONUTS page
↑ ^11.0 ^11.1 Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23452847-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Van de Vosse, DW et al. (2013) A role for the nucleoporin Nup170p in chromatin structure and gene silencing. Cell 152 969-83 PubMed GONUTS page

[PMID:20498018-2] 2.0 ^2.1 Chadrin, A et al. (2010) Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J. Cell Biol. 189 795-811 PubMed GONUTS page

[PMID:19414608-3] 3.0 ^3.1 Makio, T et al. (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J. Cell Biol. 185 459-73 PubMed GONUTS page

[PMID:18046406-4] Alber, F et al. (2007) The molecular architecture of the nuclear pore complex. Nature 450 695-701 PubMed GONUTS page

[PMID:21659568-5] Meinema, AC et al. (2011) Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science 333 90-3 PubMed GONUTS page

[PMID:16929305-6] King, MC et al. (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442 1003-7 PubMed GONUTS page

[PMID:19414606-7] Flemming, D et al. (2009) Two structurally distinct domains of the nucleoporin Nup170 cooperate to tether a subset of nucleoporins to nuclear pores. J. Cell Biol. 185 387-95 PubMed GONUTS page

[PMID:12509452-8] Shulga, N & Goldfarb, DS (2003) Binding dynamics of structural nucleoporins govern nuclear pore complex permeability and may mediate channel gating. Mol. Cell. Biol. 23 534-42 PubMed GONUTS page

[PMID:17418788-9] Patel, SS et al. (2007) Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129 83-96 PubMed GONUTS page

[PMID:11290711-10] Kerscher, O et al. (2001) Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157 1543-53 PubMed GONUTS page

[PMID:10684247-11] 11.0 ^11.1 Rout, MP et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J. Cell Biol. 148 635-51 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

YEAST:NU170

Contents

Annotations

Notes

References

a

c

d

e

f

h

m

n

o

p

r

s

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools