User:Kastorye

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	BACIU:J7JJI7	2014-04-01 19:22:13 CDT	GO:0051699 proline oxidase activity (Figure 2 C. This figure shows how the prcR mutant stops the expression of putB. Without the transcriptional activator, prcR, putB cannot be transcribed and L-proline cannot be utilized by the cell as a nutrient source. )	PMID:21964733	IMP: Inferred from Mutant Phenotype		challenge
acceptable	9RHAB:Q85422	2014-04-02 18:49:42 CDT	GO:0019031 viral envelope (C)	PMID:24244660	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1B and 1C show how the g protein of the rabies virus is required for infecting cells via binding to neuronal receptors and for viral entry. When the g protein was knocked out of the RV vector, rHEP5.0-delta G, the number of infected cells failed to increase whereas the propagation-competent RV vector rHEP5.0-CVSG was unhindered by infecting cells because it had a functional g protein.	challenge
unacceptable	HUMAN:ZA2G	2014-04-05 17:52:11 CDT	GO:0016042 lipid catabolic process (P)	PMID:24665369	ECO:0000314 direct assay evidence used in manual assertion	Zinc-α2-glycoprotein (ZAG) is described in the paper and in Figure 1a as stimulating lipid degradation in adipocytes. This is why the assay results from Figure 1a show a negative correlation between waist to hip ratio and the amount of ZAG present.	challenge
acceptable	YEFV1:POLG	2014-04-05 18:18:44 CDT	GO:0019031 viral envelope (C)	PMID:24678844	ECO:0000315 mutant phenotype evidence used in manual assertion	The infection rate of the 17D/Asibi M-E E T380R mutant (table 1) shows how the T380R mutation in EDIII favored the establishment of the viral infection in Ae. aegypti	challenge
unacceptable	HV1A2:NEF	2014-04-05 18:45:34 CDT	GO:0046903 secretion (P)	PMID:24678387	ECO:0000314 direct assay evidence used in manual assertion	The HIV Nef protein modulates cellular and exosomal miRNA profiles. The secretion of miRNA from exosomes was increased by HIV Nef protein as shown in figure 3B.	challenge
requireschanges	STRPE:P72496	2014-04-06 14:05:32 CDT	GO:0006855 drug transmembrane transport (P)	PMID:24634217	ECO:0000314 direct assay evidence used in manual assertion	Figure 1 and 3 show how the DrrAB system is involved in multi-drug transport and the kinetics of its functionality.	challenge
updatedbyinstructor	HUMAN:NOD2	2014-04-06 15:26:21 CDT	GO:1900017 positive regulation of cytokine production involved in inflammatory response (P)	PMID:24671169	ECO:0000314 direct assay evidence used in manual assertion	The results from figure 4 show how the overexpression of NOD2 restricts HCMV replication and induces antiviral and pro-inflammatory cytokines. These results show for the first time that NOD2 plays a significant role in HCMV replication and may provide a model for studies of HCMV recognition by the host cell and HCMV colitis in Crohn's disease	challenge

acceptable:2
unacceptable:2
requires_changes:2
flagged:0

Annotations challenged by Kastorye

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