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PMID:24678387
| Citation |
Aqil, M, Naqvi, AR, Mallik, S, Bandyopadhyay, S, Maulik, U and Jameel, S (2014) The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells. J Extracell Vesicles 3 |
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| Abstract |
The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs into exosomes. |
| Links |
PubMed PMC3967016 Online version:10.3402/jev.v3.23129 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0046903: secretion |
ECO:0000314: |
P |
The HIV Nef protein modulates cellular and exosomal miRNA profiles. The secretion of miRNA from exosomes was increased by HIV Nef protein as shown in figure 3B. |
complete | ||||
See also
References
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