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HV1A2:NEF
Contents
| Species (Taxon ID) | Human immunodeficiency virus type 1 group M subtype B (isolateARV2/SF2) (HIV-1). (11685) | |
| Gene Name(s) | nef | |
| Protein Name(s) | Protein Nef
3'ORF Negative factor F-protein C-terminal core protein | |
| External Links | ||
| UniProt | P03407 | |
| EMBL | K02007 | |
| PIR | A04009 | |
| PDB | 3RBB 3REA 3REB 4ORZ 4U5W | |
| PDBsum | 3RBB 3REA 3REB 4ORZ 4U5W | |
| ProteinModelPortal | P03407 | |
| SMR | P03407 | |
| DIP | DIP-29212N | |
| IntAct | P03407 | |
| MINT | MINT-1206762 | |
| EvolutionaryTrace | P03407 | |
| Proteomes | UP000007688 | |
| GO | GO:0044220 GO:0020002 GO:0016020 GO:0019012 GO:0005525 GO:0007171 GO:0006915 GO:0009405 GO:0039504 GO:0046776 GO:0039505 GO:0039521 | |
| Gene3D | 3.30.62.10 4.10.890.10 | |
| InterPro | IPR027480 IPR027481 IPR001558 | |
| Pfam | PF00469 | |
| SUPFAM | SSF55671 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007171 |
activation of transmembrane receptor protein tyrosine kinase activity |
ECO:0000314 |
P |
Figure 3 shows that when nef is present with hck it can induce tyrosine phosphorylation of endogenous proteins in wild type cells |
complete | |||||
| GO:0046903 |
secretion |
ECO:0000314 |
P |
The HIV Nef protein modulates cellular and exosomal miRNA profiles. The secretion of miRNA from exosomes was increased by HIV Nef protein as shown in figure 3B. |
complete | |||||
|
involved_in |
GO:0007171 |
activation of transmembrane receptor protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044178 |
host cell Golgi membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039505 |
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039521 |
suppression by virus of host autophagy |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046776 |
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039504 |
suppression by virus of host adaptive immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005525 |
GTP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0019012 |
virion |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000584962 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0020002 |
host cell plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009405 |
pathogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039504 |
suppression by virus of host adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039521 |
suppression by virus of host autophagy |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017124 |
SH3 domain binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033644 |
host cell membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046776 |
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030683 |
evasion or tolerance by virus of host immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0019012 |
virion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0039505 |
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044177 |
host cell Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0044178 |
host cell Golgi membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Briggs, SD et al. (1997) SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1. J. Biol. Chem. 272 17899-902 PubMed GONUTS page
- ↑ Aqil, M et al. (2014) The HIV Nef protein modulates cellular and exosomal miRNA profiles in human monocytic cells. J Extracell Vesicles 3 PubMed GONUTS page
h
o
s
- GO:0046903 ! secretion
- GO:0017124 ! SH3 domain binding
- GO:0039505 ! symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
- GO:0039504 ! symbiont-mediated suppression of host adaptive immune response
- GO:0046776 ! symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
