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HUMAN:ZA2G
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | AZGP1 (synonyms: ZAG, ZNGP1) | |
Protein Name(s) | Zinc-alpha-2-glycoprotein
Zn-alpha-2-GP Zn-alpha-2-glycoprotein | |
External Links | ||
UniProt | P25311 | |
EMBL | X59766 D14034 X69953 AC004522 CH236956 CH471091 CH471091 BC005306 BC033830 D90427 M76707 | |
CCDS | CCDS5680.1 | |
PIR | A54175 | |
RefSeq | NP_001176.1 | |
UniGene | Hs.546239 | |
PDB | 1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6 | |
PDBsum | 1T7V 1T7W 1T7X 1T7Y 1T7Z 1T80 1ZAG 3ES6 | |
ProteinModelPortal | P25311 | |
SMR | P25311 | |
BioGrid | 107040 | |
IntAct | P25311 | |
STRING | 9606.ENSP00000292401 | |
PhosphoSite | P25311 | |
DMDM | 292495049 | |
REPRODUCTION-2DPAGE | IPI00166729 | |
SWISS-2DPAGE | P25311 | |
MaxQB | P25311 | |
PaxDb | P25311 | |
PRIDE | P25311 | |
Ensembl | ENST00000292401 | |
GeneID | 563 | |
KEGG | hsa:563 | |
UCSC | uc003ush.3 | |
CTD | 563 | |
GeneCards | GC07M099564 | |
HGNC | HGNC:910 | |
HPA | CAB016087 HPA012582 | |
MIM | 194460 | |
neXtProt | NX_P25311 | |
PharmGKB | PA25203 | |
eggNOG | NOG25830 | |
GeneTree | ENSGT00760000118960 | |
HOGENOM | HOG000296917 | |
HOVERGEN | HBG016709 | |
InParanoid | P25311 | |
OMA | IFMVTLK | |
OrthoDB | EOG7JT6WQ | |
PhylomeDB | P25311 | |
TreeFam | TF336617 | |
ChiTaRS | AZGP1 | |
EvolutionaryTrace | P25311 | |
GeneWiki | AZGP1 | |
GenomeRNAi | 563 | |
NextBio | 2301 | |
PRO | PR:P25311 | |
Proteomes | UP000005640 | |
Bgee | P25311 | |
CleanEx | HS_AZGP1 | |
ExpressionAtlas | P25311 | |
Genevestigator | P25311 | |
GO | GO:0005576 GO:0005615 GO:0070062 GO:0042612 GO:0005634 GO:0001948 GO:0042605 GO:0008320 GO:0004540 GO:0002474 GO:0007155 GO:0001580 GO:0006955 GO:0008285 GO:0001916 GO:0071806 GO:0001895 GO:0090501 | |
Gene3D | 2.60.40.10 3.30.500.10 | |
InterPro | IPR007110 IPR013783 IPR003006 IPR003597 IPR011161 IPR011162 IPR027648 IPR001039 | |
Pfam | PF07654 PF00129 | |
PRINTS | PR01638 | |
SMART | SM00407 | |
SUPFAM | SSF54452 | |
PROSITE | PS50835 PS00290 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0016042 |
lipid catabolic process |
ECO:0000314 |
P |
Zinc-α2-glycoprotein (ZAG) is described in the paper and in Figure 1a as stimulating lipid degradation in adipocytes. This is why the assay results from Figure 1a show a negative correlation between waist to hip ratio and the amount of ZAG present. |
complete | |||||
part_of |
GO:0005576 |
extracellular region |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0007318) |
Seeded From UniProt |
complete | ||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000019) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001827) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001836) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001895 |
retina homeostasis |
ECO:0007007 |
high throughput expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001580 |
detection of chemical stimulus involved in sensory perception of bitter taste |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008320 |
protein transmembrane transporter activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007155 |
cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004540 |
ribonuclease activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:107674 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006955 |
immune response |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002314307 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95896 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95929 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071806 |
protein transmembrane transport |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008320 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090501 |
RNA phosphodiester bond hydrolysis |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004540 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0055085 |
transmembrane transport |
Reactome:R-HSA-5223345 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-5252072 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Zhu, HJ et al. (2014) Serum Levels of the Adipokine Zinc- α 2-glycoprotein Are Decreased in Patients with Hypertension. ISRN Endocrinol 2014 374090 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
- ↑ Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 8.0 8.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
- ↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
- ↑ 10.0 10.1 Morzel, M et al. (2014) Salivary protein profiles are linked to bitter taste acceptance in infants. Eur. J. Pediatr. 173 575-82 PubMed GONUTS page
- ↑ Shibata, S & Miura, K (1982) Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine. Nephron 31 170-6 PubMed GONUTS page
- ↑ 12.0 12.1 Lei, G et al. (1999) Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line. J. Cell. Biochem. 75 160-9 PubMed GONUTS page
- ↑ Ogikubo, O et al. (1998) Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives. Biochem. Biophys. Res. Commun. 252 257-62 PubMed GONUTS page
- ↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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