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HUMAN:ZA2G

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) AZGP1 (synonyms: ZAG, ZNGP1)
Protein Name(s) Zinc-alpha-2-glycoprotein

Zn-alpha-2-GP Zn-alpha-2-glycoprotein

External Links
UniProt P25311
EMBL X59766
D14034
X69953
AC004522
CH236956
CH471091
CH471091
BC005306
BC033830
D90427
M76707
CCDS CCDS5680.1
PIR A54175
RefSeq NP_001176.1
UniGene Hs.546239
PDB 1T7V
1T7W
1T7X
1T7Y
1T7Z
1T80
1ZAG
3ES6
PDBsum 1T7V
1T7W
1T7X
1T7Y
1T7Z
1T80
1ZAG
3ES6
ProteinModelPortal P25311
SMR P25311
BioGrid 107040
IntAct P25311
STRING 9606.ENSP00000292401
PhosphoSite P25311
DMDM 292495049
REPRODUCTION-2DPAGE IPI00166729
SWISS-2DPAGE P25311
MaxQB P25311
PaxDb P25311
PRIDE P25311
Ensembl ENST00000292401
GeneID 563
KEGG hsa:563
UCSC uc003ush.3
CTD 563
GeneCards GC07M099564
HGNC HGNC:910
HPA CAB016087
HPA012582
MIM 194460
neXtProt NX_P25311
PharmGKB PA25203
eggNOG NOG25830
GeneTree ENSGT00760000118960
HOGENOM HOG000296917
HOVERGEN HBG016709
InParanoid P25311
OMA IFMVTLK
OrthoDB EOG7JT6WQ
PhylomeDB P25311
TreeFam TF336617
ChiTaRS AZGP1
EvolutionaryTrace P25311
GeneWiki AZGP1
GenomeRNAi 563
NextBio 2301
PRO PR:P25311
Proteomes UP000005640
Bgee P25311
CleanEx HS_AZGP1
ExpressionAtlas P25311
Genevestigator P25311
GO GO:0005576
GO:0005615
GO:0070062
GO:0042612
GO:0005634
GO:0001948
GO:0042605
GO:0008320
GO:0004540
GO:0002474
GO:0007155
GO:0001580
GO:0006955
GO:0008285
GO:0001916
GO:0071806
GO:0001895
GO:0090501
Gene3D 2.60.40.10
3.30.500.10
InterPro IPR007110
IPR013783
IPR003006
IPR003597
IPR011161
IPR011162
IPR027648
IPR001039
Pfam PF07654
PF00129
PRINTS PR01638
SMART SM00407
SUPFAM SSF54452
PROSITE PS50835
PS00290

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016042

lipid catabolic process

PMID:24665369[1]

ECO:0000314

P

Zinc-α2-glycoprotein (ZAG) is described in the paper and in Figure 1a as stimulating lipid degradation in adipocytes. This is why the assay results from Figure 1a show a negative correlation between waist to hip ratio and the amount of ZAG present.

complete
CACAO 9902

part_of

GO:0005576

extracellular region

PMID:27068509[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:16502470[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001914)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23580065[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:22664934[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24248522[10]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001836)

Seeded From UniProt

complete

involved_in

GO:0001895

retina homeostasis

PMID:23580065[8]

ECO:0007007

high throughput expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

PMID:24248522[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008320

protein transmembrane transporter activity

PMID:6896906[11]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:10462714[12]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

PMID:9813179[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:14718574[14]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004540

ribonuclease activity

PMID:10462714[12]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107674
MGI:MGI:109431
MGI:MGI:109432
MGI:MGI:1861032
MGI:MGI:1925027
MGI:MGI:2179988
MGI:MGI:2179989
MGI:MGI:95896
MGI:MGI:95904
MGI:MGI:95915
MGI:MGI:95938
PANTHER:PTN002314307
UniProtKB:Q30201

C

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002314307
UniProtKB:P01891
UniProtKB:Q31612

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95896
PANTHER:PTN002314307
UniProtKB:Q95460
UniProtKB:Q9BZM6

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:95929
PANTHER:PTN002314307
UniProtKB:P25311
UniProtKB:Q29983
UniProtKB:Q30201
UniProtKB:Q9BZM5

C

Seeded From UniProt

complete

involved_in

GO:0071806

protein transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008320

P

Seeded From UniProt

complete

involved_in

GO:0090501

RNA phosphodiester bond hydrolysis

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004540

P

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

Reactome:R-HSA-5223345

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-5252072

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Zhu, HJ et al. (2014) Serum Levels of the Adipokine Zinc- α 2-glycoprotein Are Decreased in Patients with Hypertension. ISRN Endocrinol 2014 374090 PubMed GONUTS page
  2. Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  3. Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  4. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  5. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  6. de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  7. Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
  8. 8.0 8.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
  9. Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
  10. 10.0 10.1 Morzel, M et al. (2014) Salivary protein profiles are linked to bitter taste acceptance in infants. Eur. J. Pediatr. 173 575-82 PubMed GONUTS page
  11. Shibata, S & Miura, K (1982) Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine. Nephron 31 170-6 PubMed GONUTS page
  12. 12.0 12.1 Lei, G et al. (1999) Characterization of zinc-alpha(2)-glycoprotein as a cell adhesion molecule that inhibits the proliferation of an oral tumor cell line. J. Cell. Biochem. 75 160-9 PubMed GONUTS page
  13. Ogikubo, O et al. (1998) Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives. Biochem. Biophys. Res. Commun. 252 257-62 PubMed GONUTS page
  14. Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page