User:Cheem005

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	?	2012-02-12 11:22:27 CST	GO:0030017 sarcomere (There are less contraction in the sarcomeres of the mouse with mutant gene. Fig 2)	PMID:22174871	IMP: Inferred from Mutant Phenotype		challenge
requireschanges	?	2012-02-12 11:58:47 CST	GO:0030240 skeletal muscle thin filament assembly (There is only a small amino acid difference in the mutant protein. Isoleucine 357 to Leucine but they result in a lethal phenotype. Molecular modeling of this mutation highlights potential alterations in hydrogen bonding at the extreme C-terminus of G-actin. Fig. 8)	PMID:15198992	IMP: Inferred from Mutant Phenotype		challenge
requireschanges	MOUSE:JKAMP	2012-02-12 13:58:38 CST	GO:0016020 membrane (C)	PMID:16166642	ECO:0000314 direct assay evidence used in manual assertion	Fig 3	challenge
requireschanges	HUMAN:HBA	2012-02-26 10:28:41 CST	GO:0005515 protein binding (F)	other:PMC2700329	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 1 shows how different mutations affect it coming in contact with AHSP and beta globin.	challenge
requireschanges	HUMAN:AHSP	2012-02-26 10:43:38 CST	GO:0051082 unfolded protein binding (F)	other:PMC2878560	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 shows the thermal unfolding curve of the wild type, isolated and the mutant AHSP protein	challenge
requireschanges	MOUSE:GTR2	2012-02-26 12:07:11 CST	GO:0015755 fructose transport (P)	other:PMC2343460	ECO:0000315 mutant phenotype evidence used in manual assertion	Table 2 shows that glycaemia was lower in GLUT2-null mice on high fructose diet.	challenge

acceptable:0
unacceptable:0
requires_changes:6
flagged:0

Annotations challenged by Cheem005

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
acceptable	Wedde001, Team The Dynamic Protein Duo	HUMAN:IGF1R	GO:0004713 - protein tyrosine kinase activity (F)	PMID:11884589	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
unacceptable	Wedde001, Team The Dynamic Protein Duo	ECOLI:MREB	GO:0005200 - structural constituent of cytoskeleton (F)	PMID:19346310	ECO:0000270 expression pattern evidence used in manual assertion	challenge	C: 1
requireschanges	Wedde001, Team The Dynamic Protein Duo	ECOLI:DACA	GO:0008658 - penicillin binding (F)	PMID:10692378	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Cheem005