MOUSE:GTR2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Slc2a2 (synonyms: Glut-2, Glut2)
Protein Name(s)	Solute carrier family 2, facilitated glucose transporter member 2 Glucose transporter type 2, liver GLUT-2
External Links
UniProt	P14246
EMBL	X16986 X15684 S77926 AK005068 AK165430 BC034675 X78722
CCDS	CCDS50880.1
PIR	S06920
RefSeq	NP_112474.2
UniGene	Mm.18443
ProteinModelPortal	P14246
SMR	P14246
MINT	MINT-1863175
PhosphoSite	P14246
MaxQB	P14246
PaxDb	P14246
PRIDE	P14246
Ensembl	ENSMUST00000029240
GeneID	20526
KEGG	mmu:20526
UCSC	uc008oua.2
CTD	6514
MGI	MGI:1095438
eggNOG	COG0477
GeneTree	ENSGT00760000119022
HOGENOM	HOG000202871
HOVERGEN	HBG014816
InParanoid	P14246
KO	K07593
OMA	AFSNWVC
OrthoDB	EOG7QVM2R
PhylomeDB	P14246
TreeFam	TF313762
Reactome	REACT_206357 REACT_214529 REACT_240125 REACT_253543 REACT_263148
ChiTaRS	Slc2a2
NextBio	298767
PRO	PR:P14246
Proteomes	UP000000589
Bgee	P14246
ExpressionAtlas	P14246
Genevestigator	P14246
GO	GO:0005903 GO:0005737 GO:0016021 GO:0005886 GO:0055056 GO:0033300 GO:0005355 GO:0008643 GO:0070837 GO:0031018 GO:0015758
InterPro	IPR002440 IPR020846 IPR005828 IPR003663 IPR005829
Pfam	PF00083
PRINTS	PR01191 PR00171
SUPFAM	SSF103473
TIGRFAMs	TIGR00879
PROSITE	PS50850 PS00216 PS00217

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0015755	fructose transport	other:PMC2343460	ECO:0000315			P		Table 2 shows that glycaemia was lower in GLUT2-null mice on high fructose diet.	complete CACAO 3851
involved_in	GO:0070837	dehydroascorbic acid transport	PMID:18668520^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0055056	D-glucose transmembrane transporter activity	PMID:18668520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033300	dehydroascorbic acid transmembrane transporter activity	PMID:18668520^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1904659	glucose transmembrane transport	PMID:18668520^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18668520^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904659	glucose transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070837	dehydroascorbic acid transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	P		Seeded From UniProt	complete
enables	GO:0055056	D-glucose transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	F		Seeded From UniProt	complete
enables	GO:0033300	dehydroascorbic acid transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	F		Seeded From UniProt	complete
part_of	GO:0031526	brush border membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	PMID:19841136^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16085)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009758	carbohydrate utilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:17928203^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:11287626^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:15601832^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005903	brush border	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18511518^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14736883^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:14702043^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18816) part_of:(CL:0000169)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12921743^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	C		Seeded From UniProt	complete
enables	GO:0005355	glucose transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	F		Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3705	F		Seeded From UniProt	complete
enables	GO:0005215	transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005829	F		Seeded From UniProt	complete
enables	GO:0005355	glucose transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002440	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002440 InterPro:IPR003663	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005828 InterPro:IPR005829	C		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003663 InterPro:IPR005828	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003663 InterPro:IPR005828 InterPro:IPR005829	P		Seeded From UniProt	complete
involved_in	GO:1904659	glucose transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002440	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	Reactome:R-MMU-210774	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-186469	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008643	carbohydrate transport	PMID:15601832^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005355	glucose transmembrane transporter activity	PMID:15601832^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0008643	carbohydrate transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0762	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Angulo, C et al. (2008) Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J. Cell. Physiol. 217 708-16 PubMed GONUTS page
↑ Vijayaraj, P et al. (2009) Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J. Cell Biol. 187 175-84 PubMed GONUTS page
↑ Wang, S et al. () Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev. 124 898-910 PubMed GONUTS page
↑ Párrizas, M et al. (2001) Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol. Cell. Biol. 21 3234-43 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Osswald, C et al. (2005) Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol. Cell. Biol. 25 78-87 PubMed GONUTS page
↑ Jiang, X et al. (2008) The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am. J. Pathol. 172 1748-56 PubMed GONUTS page
↑ Härndahl, L et al. (2004) Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J. Biol. Chem. 279 15214-22 PubMed GONUTS page
↑ Sumazaki, R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 36 83-7 PubMed GONUTS page
↑ Hald, J et al. (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260 426-37 PubMed GONUTS page

[PMID:18668520-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Angulo, C et al. (2008) Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. J. Cell. Physiol. 217 708-16 PubMed GONUTS page

[PMID:19841136-2] Vijayaraj, P et al. (2009) Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor. J. Cell Biol. 187 175-84 PubMed GONUTS page

[PMID:17928203-3] Wang, S et al. () Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech. Dev. 124 898-910 PubMed GONUTS page

[PMID:11287626-4] Párrizas, M et al. (2001) Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol. Cell. Biol. 21 3234-43 PubMed GONUTS page

[PMID:15601832-5] 5.0 ^5.1 ^5.2 Osswald, C et al. (2005) Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol. Cell. Biol. 25 78-87 PubMed GONUTS page

[PMID:18511518-6] Jiang, X et al. (2008) The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am. J. Pathol. 172 1748-56 PubMed GONUTS page

[PMID:14736883-7] Härndahl, L et al. (2004) Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J. Biol. Chem. 279 15214-22 PubMed GONUTS page

[PMID:14702043-8] Sumazaki, R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat. Genet. 36 83-7 PubMed GONUTS page

[PMID:12921743-9] Hald, J et al. (2003) Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev. Biol. 260 426-37 PubMed GONUTS page

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MOUSE:GTR2

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