HUMAN:HBA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HBA2
Protein Name(s)	Hemoglobin subunit alpha Alpha-globin Hemoglobin alpha chain
External Links
UniProt	P69905
EMBL	J00153 J00153 V00491 V00493 V00488 V00516 AF230076 AF525460 DQ431198 DQ431198 AF097635 AF105974 AF349571 AF536204 DQ499017 DQ499018 AK223392 AE006462 AE006462 Z84721 Z84721 BC005931 BC008572 BC032122 BC050661 BC101846 BC101848
CCDS	CCDS10398.1 CCDS10399.1
PIR	A90807 C93303 I58217
RefSeq	NP_000508.1 NP_000549.1
UniGene	Hs.449630 Hs.654744
PDB	1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4MQJ 4MQK 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 6HBW
PDBsum	1A00 1A01 1A0U 1A0Z 1A3N 1A3O 1A9W 1ABW 1ABY 1AJ9 1B86 1BAB 1BBB 1BIJ 1BUW 1BZ0 1BZ1 1BZZ 1C7B 1C7C 1C7D 1CLS 1CMY 1COH 1DKE 1DXT 1DXU 1DXV 1FDH 1FN3 1G9V 1GBU 1GBV 1GLI 1GZX 1HAB 1HAC 1HBA 1HBB 1HBS 1HCO 1HDB 1HGA 1HGB 1HGC 1HHO 1IRD 1J3Y 1J3Z 1J40 1J41 1J7S 1J7W 1J7Y 1JY7 1K0Y 1K1K 1KD2 1LFL 1LFQ 1LFT 1LFV 1LFY 1LFZ 1LJW 1M9P 1MKO 1NEJ 1NIH 1NQP 1O1I 1O1J 1O1K 1O1L 1O1M 1O1N 1O1O 1O1P 1QI8 1QSH 1QSI 1QXD 1QXE 1R1X 1R1Y 1RPS 1RQ3 1RQ4 1RQA 1RVW 1SDK 1SDL 1SHR 1SI4 1THB 1UIW 1VWT 1XXT 1XY0 1XYE 1XZ2 1XZ4 1XZ5 1XZ7 1XZU 1XZV 1Y01 1Y09 1Y0A 1Y0C 1Y0D 1Y0T 1Y0W 1Y22 1Y2Z 1Y31 1Y35 1Y45 1Y46 1Y4B 1Y4F 1Y4G 1Y4P 1Y4Q 1Y4R 1Y4V 1Y5F 1Y5J 1Y5K 1Y7C 1Y7D 1Y7G 1Y7Z 1Y83 1Y85 1Y8W 1YDZ 1YE0 1YE1 1YE2 1YEN 1YEO 1YEQ 1YEU 1YEV 1YFF 1YG5 1YGD 1YGF 1YH9 1YHE 1YHR 1YIE 1YIH 1YVQ 1YVT 1YZI 1Z8U 2D5Z 2D60 2DN1 2DN2 2DN3 2DXM 2H35 2HBC 2HBD 2HBE 2HBF 2HBS 2HCO 2HHB 2HHD 2HHE 2M6Z 2W6V 2W72 2YRS 3B75 3D17 3D7O 3DUT 3HHB 3HXN 3IA3 3IC0 3IC2 3KMF 3NL7 3NMM 3ODQ 3ONZ 3OO4 3OO5 3OVU 3P5Q 3QJB 3QJC 3QJD 3QJE 3R5I 3S48 3S65 3S66 3SZK 3WCP 3WHM 4FC3 4HHB 4IJ2 4L7Y 4M4A 4M4B 4MQC 4MQG 4MQH 4MQI 4MQJ 4MQK 4N7N 4N7O 4N7P 4N8T 4NI0 4NI1 6HBW
ProteinModelPortal	P69905
SMR	P69905
BioGrid	109289 109290
DIP	DIP-35199N
IntAct	P69905
MINT	MINT-1519936
STRING	9606.ENSP00000251595
ChEMBL	CHEMBL2095168
DrugBank	DB00893 DB00358
PhosphoSite	P69905
DMDM	57013850
DOSAC-COBS-2DPAGE	P69905
REPRODUCTION-2DPAGE	IPI00410714
SWISS-2DPAGE	P69905
UCD-2DPAGE	P01922 P69905
MaxQB	P69905
PaxDb	P69905
PeptideAtlas	P69905
PRIDE	P69905
DNASU	3039
Ensembl	ENST00000251595 ENST00000320868
GeneID	3039 3040
KEGG	hsa:3039 hsa:3040
UCSC	uc002cfv.4
CTD	3039 3040
GeneCards	GC16P000298 GC16P000300
GeneReviews	HBA1 HBA2
HGNC	HGNC:4823 HGNC:4824
HPA	CAB032534 CAB038417 HPA043780
MIM	140700 141800 141850 141860 604131 613978
neXtProt	NX_P69905
Orphanet	98791 330041 163596 93616
PharmGKB	PA29199
eggNOG	NOG283543
GeneTree	ENSGT00760000119197
HOVERGEN	HBG009709
InParanoid	P69905
KO	K13822
OMA	DKFLCAV
OrthoDB	EOG7KH9MP
PhylomeDB	P69905
TreeFam	TF332328
Reactome	REACT_121329 REACT_121380 REACT_160163
ChiTaRS	HBA1 HBA2
EvolutionaryTrace	P69905
GeneWiki	HBA2 Hemoglobin,_alpha_1 Hemoglobin,_alpha_2
NextBio	12034
PMAP-CutDB	P69905
PRO	PR:P69905
Proteomes	UP000005640
Bgee	P69905
CleanEx	HS_HBA1 HS_HBA2
ExpressionAtlas	P69905
Genevestigator	P69905
GO	GO:0072562 GO:0005829 GO:0022627 GO:0071682 GO:0005576 GO:0070062 GO:0031838 GO:0005833 GO:0016020 GO:0020037 GO:0005506 GO:0019825 GO:0005344 GO:0015701 GO:0042744 GO:0055114 GO:0015671 GO:0010942 GO:0051291 GO:0042542 GO:0044281
Gene3D	1.10.490.10
InterPro	IPR000971 IPR009050 IPR012292 IPR002338 IPR002339
Pfam	PF00042
PRINTS	PR00612 PR00815
SUPFAM	SSF46458
PROSITE	PS01033

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
Contributes to	GO:0031720	haptoglobin binding	PMID:19740759^[1]	ECO:0000314			F		Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin.	complete
	GO:0031838	haptoglobin-hemoglobin complex	PMID:19740759^[1]	ECO:0000314			C		Fig 2 shows haemoglobin-haptoglobin complexes and how EPR signal varies compared to pure haemoglobin.	complete
Contributes to	GO:0004601	peroxidase activity	PMID:19740759^[1]	ECO:0000314			F		Fig 5 shows positive peroxidase activity of haemoglobin and of haemoglobin-haptoglobin complexes.	complete
Contributes to	GO:0042542	response to hydrogen peroxide	PMID:19740759^[1]	ECO:0000314			P		Fig 3: large MW aggregates can be seen after addition of hydrogen peroxide when both haemoglobin and haptoglobin are present.	complete
	GO:0005515	protein binding	other:PMC2700329	ECO:0000315			F		Table 1 shows how different mutations affect it coming in contact with AHSP and beta globin.	complete CACAO 3846
part_of	GO:0005615	extracellular space	PMID:21805676^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0051291	protein heterooligomerization	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031838	haptoglobin-hemoglobin complex	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0031720	haptoglobin binding	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005833	hemoglobin complex	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
contributes_to	GO:0004601	peroxidase activity	PMID:19740759^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0022627	cytosolic small ribosomal subunit	PMID:8706699^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0043177	organic acid binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 RGD:1359209	F		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 UniProtKB:P68871 UniProtKB:P69905	P		Seeded From UniProt	complete
part_of	GO:0031838	haptoglobin-hemoglobin complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 UniProtKB:P68871 UniProtKB:P69905	C		Seeded From UniProt	complete
contributes_to	GO:0031720	haptoglobin binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 UniProtKB:P68871 UniProtKB:P69905	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 RGD:1359209 RGD:620306	F		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96022 PANTHER:PTN000154218 UniProtKB:P68871 UniProtKB:Q5QRU6	F		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96022 PANTHER:PTN000154218 RGD:1359209 RGD:2783 UniProtKB:P68871 UniProtKB:Q5QRU6	F		Seeded From UniProt	complete
part_of	GO:0005833	hemoglobin complex	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96021 MGI:MGI:96022 PANTHER:PTN000154218 RGD:1305115 RGD:1359209 RGD:2783 RGD:620306 UniProtKB:P68871 UniProtKB:P69905	C		Seeded From UniProt	complete
enables	GO:0005344	oxygen carrier activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96021 PANTHER:PTN000154218	F		Seeded From UniProt	complete
contributes_to	GO:0004601	peroxidase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000154218 UniProtKB:P68871 UniProtKB:P69905	F		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002339	F		Seeded From UniProt	complete
part_of	GO:0005833	hemoglobin complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002338 InterPro:IPR002339	C		Seeded From UniProt	complete
involved_in	GO:0015671	oxygen transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002338 InterPro:IPR002339	P		Seeded From UniProt	complete
enables	GO:0019825	oxygen binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002339 InterPro:IPR012292	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000971 InterPro:IPR002338 InterPro:IPR002339 InterPro:IPR012292	F		Seeded From UniProt	complete
involved_in	GO:0015671	oxygen transport	PMID:7518430^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005833	hemoglobin complex	PMID:7555018^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0071682	endocytic vesicle lumen	Reactome:R-HSA-2230938	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	Reactome:R-HSA-1247673 Reactome:R-HSA-1237044	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	Reactome:R-HSA-2173782	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6806831 Reactome:R-HSA-1247668 Reactome:R-HSA-1237325	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-2230938 Reactome:R-HSA-2168889 Reactome:R-HSA-2168885 Reactome:R-HSA-2168884 Reactome:R-HSA-2168883	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005344	oxygen carrier activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0561	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0015671	oxygen transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0561	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Kapralov, A et al. (2009) Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages. J. Biol. Chem. 284 30395-407 PubMed GONUTS page
↑ Fornander, L et al. (2011) Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Proteomics Clin Appl 5 513-22 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ ^6.0 ^6.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Vladimirov, SN et al. (1996) Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. 239 144-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sanna, MT et al. (1994) Functional alterations in adult and fetal hemoglobin Sassari Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact. J. Biol. Chem. 269 18338-42 PubMed GONUTS page
↑ Giardina, B et al. (1995) The multiple functions of hemoglobin. Crit. Rev. Biochem. Mol. Biol. 30 165-96 PubMed GONUTS page

[PMID:19740759-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Kapralov, A et al. (2009) Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages. J. Biol. Chem. 284 30395-407 PubMed GONUTS page

[PMID:21805676-2] Fornander, L et al. (2011) Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Proteomics Clin Appl 5 513-22 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-4] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22516433-5] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:20458337-6] 6.0 ^6.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:8706699-7] Vladimirov, SN et al. (1996) Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur. J. Biochem. 239 144-9 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 ^8.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7518430-9] Sanna, MT et al. (1994) Functional alterations in adult and fetal hemoglobin Sassari Asp-alpha 126(H9)-->His. The role of alpha 1 alpha 2 contact. J. Biol. Chem. 269 18338-42 PubMed GONUTS page

[PMID:7555018-10] Giardina, B et al. (1995) The multiple functions of hemoglobin. Crit. Rev. Biochem. Mol. Biol. 30 165-96 PubMed GONUTS page

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HUMAN:HBA

Contents

Annotations

Notes

References

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