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PMID:7555018

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Citation

Giardina, B, Messana, I, Scatena, R and Castagnola, M (1995) The multiple functions of hemoglobin. Crit. Rev. Biochem. Mol. Biol. 30:165-96

Abstract

The aim of this review is to focus and discuss several parallel biological functions of hemoglobin besides its basic function of oxygen transport. In light of the information present in the literature the following possible physiological roles of hemoglobin are discussed: (1) hemoglobin as molecular heat transducer through its oxygenation-deoxygenation cycle, (2) hemoglobin as modulator of erythrocyte metabolism, (3) hemoglobin oxidation as an onset of erythrocyte senescence, (4) hemoglobin and its implication in genetic resistance to malaria, (5) enzymatic activities of hemoglobin and interactions with drugs, and (6) hemoglobin as source of physiological active catabolites.

Links

PubMed Online version:10.3109/10409239509085142

Keywords

Amino Acid Sequence; Animals; Body Temperature Regulation/physiology; Erythrocyte Aging/physiology; Erythrocytes/metabolism; Female; Hemoglobins/genetics; Hemoglobins/metabolism; Hemoglobins/physiology; Humans; Malaria/genetics; Maternal-Fetal Exchange/physiology; Methemoglobin/metabolism; Molecular Sequence Data; Oxyhemoglobins/metabolism; Pregnancy

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:HBAZ

enables

GO:0005344: oxygen carrier activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:HBAZ

part_of

GO:0005833: hemoglobin complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HBD

part_of

GO:0005833: hemoglobin complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HBE

enables

GO:0005344: oxygen carrier activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:HBE

part_of

GO:0005833: hemoglobin complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HBAT

involved_in

GO:0015671: oxygen transport

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:HBAT

part_of

GO:0005833: hemoglobin complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

HUMAN:HBA

part_of

GO:0005833: hemoglobin complex

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete


See also

References

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