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RAT:OXYR

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Oxtr (synonyms: Otr)
Protein Name(s) Oxytocin receptor

OT-R

External Links
UniProt P70536
EMBL U15280
U15169
AY338194
RefSeq NP_037003.2
XP_006237070.1
XP_008761401.1
XP_008761402.1
XP_008761403.1
XP_008761404.1
UniGene Rn.6841
ProteinModelPortal P70536
BindingDB P70536
ChEMBL CHEMBL3996
GuidetoPHARMACOLOGY 369
PhosphoSite P70536
PaxDb P70536
PRIDE P70536
Ensembl ENSRNOT00000007724
GeneID 25342
KEGG rno:25342
UCSC RGD:3239
CTD 5021
RGD 3239
eggNOG NOG299951
GeneTree ENSGT00760000119156
HOGENOM HOG000237331
HOVERGEN HBG105710
InParanoid P70536
KO K04229
OMA GPPRRNE
OrthoDB EOG7Z69CP
PhylomeDB P70536
TreeFam TF106499
Reactome REACT_263111
REACT_263374
NextBio 606255
PRO PR:P70536
Proteomes UP000002494
Genevestigator P70536
GO GO:0016324
GO:0005913
GO:0016021
GO:0005902
GO:0004990
GO:0017046
GO:0005000
GO:0048565
GO:0042755
GO:0070371
GO:0007565
GO:0007186
GO:0007507
GO:0042711
GO:0060137
GO:0007613
GO:0060455
GO:0045777
GO:0007204
GO:0010701
GO:0060406
GO:0051965
GO:0032230
GO:0051968
GO:0070474
GO:0044058
GO:0001975
GO:0034059
GO:0042220
GO:0034097
GO:0042493
GO:0032355
GO:0014070
GO:0043434
GO:0032570
GO:0048545
GO:0030431
GO:0035176
GO:0042713
GO:0001967
GO:0021537
InterPro IPR000276
IPR017452
IPR002062
IPR001817
Pfam PF00001
PRINTS PR00237
PR00665
PR00896
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004990

oxytocin receptor activity

PMID:22420322[1]

ECO:0000314

F

Figure 2. shows the binding data to support

complete
CACAO 9310

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:24002032[2]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P97926

P

Seeded From UniProt

complete

involved_in

GO:0070474

positive regulation of uterine smooth muscle contraction

PMID:19164477[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070371

ERK1 and ERK2 cascade

PMID:10497238[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060455

negative regulation of gastric acid secretion

PMID:11764003[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060406

positive regulation of penile erection

PMID:18469843[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060137

maternal process involved in parturition

PMID:18936075[7]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051968

positive regulation of synaptic transmission, glutamatergic

PMID:18510735[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051965

positive regulation of synapse assembly

PMID:16488155[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048565

digestive tract development

PMID:19003903[10]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048545

response to steroid hormone

PMID:12588901[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044849

estrous cycle

PMID:12867731[12]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044058

regulation of digestive system process

PMID:12690433[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043434

response to peptide hormone

PMID:17537544[14]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043434

response to peptide hormone

PMID:12700188[15]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042755

eating behavior

PMID:15380376[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042713

sperm ejaculation

PMID:18469843[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042711

maternal behavior

PMID:18513132[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:15380831[18]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

PMID:12834913[19]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042220

response to cocaine

PMID:16677710[20]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:17383105[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034097

response to cytokine

PMID:10994633[22]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034059

response to anoxia

PMID:18655887[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

PMID:10856882[24]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032355

response to estradiol

PMID:19258489[25]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032230

positive regulation of synaptic transmission, GABAergic

PMID:11069593[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030431

sleep

PMID:12832103[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021537

telencephalon development

PMID:11021977[28]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0017046

peptide hormone binding

PMID:15821089[29]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:11456414[30]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:12504828[31]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014070

response to organic cyclic compound

PMID:11264328[32]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010701

positive regulation of norepinephrine secretion

PMID:14656297[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007613

memory

PMID:18304743[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:16832906[35]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

PMID:15316117[36]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:10497238[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:9575824[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

PMID:19003903[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005902

microvillus

PMID:11456414[30]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004990

oxytocin receptor activity

PMID:19560475[38]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004990

oxytocin receptor activity

PMID:15821089[29]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001975

response to amphetamine

PMID:17383105[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001967

suckling behavior

PMID:19106214[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045907

positive regulation of vasoconstriction

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662574
RGD:2185

P

Seeded From UniProt

complete

involved_in

GO:0042711

maternal behavior

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662660
RGD:3239

P

Seeded From UniProt

complete

involved_in

GO:0035176

social behavior

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662660
RGD:3239

P

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202348
RGD:2289

P

Seeded From UniProt

complete

involved_in

GO:0007565

female pregnancy

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662660
RGD:3239

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0025595
PANTHER:PTN001202348
RGD:3239
RGD:61886
RGD:70513
ZFIN:ZDB-GENE-050419-76
ZFIN:ZDB-GENE-090128-3

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0038880
PANTHER:PTN001202348

C

Seeded From UniProt

complete

enables

GO:0005000

vasopressin receptor activity

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001202415
RGD:2185
RGD:61886

F

Seeded From UniProt

complete

enables

GO:0004990

oxytocin receptor activity

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000662657
RGD:3239

F

Seeded From UniProt

complete

involved_in

GO:0001992

regulation of systemic arterial blood pressure by vasopressin

PMID:21873635[40]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1347010
MGI:MGI:1859216
PANTHER:PTN000662574

P

Seeded From UniProt

complete

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97926
ensembl:ENSMUSP00000051132

P

Seeded From UniProt

complete

involved_in

GO:0045777

positive regulation of blood pressure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P97926
ensembl:ENSMUSP00000051132

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004990

oxytocin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002062

F

Seeded From UniProt

complete

enables

GO:0005000

vasopressin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001817

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001817
InterPro:IPR002062

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001817
InterPro:IPR002062
InterPro:IPR017452

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Hicks, C et al. (2012) The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. J. Neuroendocrinol. 24 1012-29 PubMed GONUTS page
  2. Kasahara, Y et al. (2013) Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice. Endocrinology 154 4305-15 PubMed GONUTS page
  3. Magalhaes, JK et al. (2009) Oxytocin pretreatment decreases oxytocin-induced myometrial contractions in pregnant rats in a concentration-dependent but not time-dependent manner. Reprod Sci 16 501-8 PubMed GONUTS page
  4. 4.0 4.1 Hoare, S et al. (1999) The proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular stores. J. Biol. Chem. 274 28682-9 PubMed GONUTS page
  5. Asad, M et al. (2001) Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life Sci. 70 17-24 PubMed GONUTS page
  6. 6.0 6.1 Clément, P et al. (2008) Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats. Br. J. Pharmacol. 154 1150-9 PubMed GONUTS page
  7. Arthur, P et al. (2008) Relationship between gene expression and function of uterotonic systems in the rat during gestation, uterine activation and both term and preterm labour. J. Physiol. (Lond.) 586 6063-76 PubMed GONUTS page
  8. Breton, JD et al. (2008) Oxytocin-induced antinociception in the spinal cord is mediated by a subpopulation of glutamatergic neurons in lamina I-II which amplify GABAergic inhibition. Mol Pain 4 19 PubMed GONUTS page
  9. Theodosis, DT et al. (2006) Oxytocin and estrogen promote rapid formation of functional GABA synapses in the adult supraoptic nucleus. Mol. Cell. Neurosci. 31 785-94 PubMed GONUTS page
  10. 10.0 10.1 Welch, MG et al. (2009) Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. J. Comp. Neurol. 512 256-70 PubMed GONUTS page
  11. Widmer, H et al. (2003) Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus. J. Physiol. (Lond.) 548 233-44 PubMed GONUTS page
  12. Murata, T et al. (2003) Changes of receptor mRNAs for oxytocin and estrogen during the estrous cycle in rat uterus. J. Vet. Med. Sci. 65 707-12 PubMed GONUTS page
  13. Wu, CL et al. (2003) Pharmacological effects of oxytocin on gastric emptying and intestinal transit of a non-nutritive liquid meal in female rats. Naunyn Schmiedebergs Arch. Pharmacol. 367 406-13 PubMed GONUTS page
  14. Pournajafi-Nazarloo, H et al. (2007) Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart. Peptides 28 1170-7 PubMed GONUTS page
  15. Mitchell, JA et al. (2003) Parathyroid hormone-related protein treatment of pregnant rats delays the increase in connexin 43 and oxytocin receptor expression in the myometrium. Biol. Reprod. 69 556-62 PubMed GONUTS page
  16. Verty, AN et al. (2004) Evidence for an interaction between CB1 cannabinoid and oxytocin receptors in food and water intake. Neuropharmacology 47 593-603 PubMed GONUTS page
  17. Figueira, RJ et al. (2008) Oxytocin receptor activity in the ventrocaudal periaqueductal gray modulates anxiety-related behavior in postpartum rats. Behav. Neurosci. 122 618-28 PubMed GONUTS page
  18. Johns, JM et al. () Gestational treatment with cocaine and fluoxetine alters oxytocin receptor number and binding affinity in lactating rat dams. Int. J. Dev. Neurosci. 22 321-8 PubMed GONUTS page
  19. Patisaul, HB et al. (2003) Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus. Brain Res. 978 185-93 PubMed GONUTS page
  20. Jarrett, TM et al. (2006) Cocaine treatment alters oxytocin receptor binding but not mRNA production in postpartum rat dams. Neuropeptides 40 161-7 PubMed GONUTS page
  21. 21.0 21.1 Thompson, MR et al. (2007) A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience 146 509-14 PubMed GONUTS page
  22. Fang, X et al. (2000) Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus. Am. J. Reprod. Immunol. 44 65-72 PubMed GONUTS page
  23. Khazipov, R et al. (2008) Effects of oxytocin on GABA signalling in the foetal brain during delivery. Prog. Brain Res. 170 243-57 PubMed GONUTS page
  24. Murata, T et al. (2000) Oxytocin receptor gene expression in rat uterus: regulation by ovarian steroids. J. Endocrinol. 166 45-52 PubMed GONUTS page
  25. Feng, M et al. (2009) Estradiol upregulates the expression of oxytocin receptor in colon in rats. Am. J. Physiol. Endocrinol. Metab. 296 E1059-66 PubMed GONUTS page
  26. Zaninetti, M & Raggenbass, M (2000) Oxytocin receptor agonists enhance inhibitory synaptic transmission in the rat hippocampus by activating interneurons in stratum pyramidale. Eur. J. Neurosci. 12 3975-84 PubMed GONUTS page
  27. Lancel, M et al. (2003) Intracerebral oxytocin modulates sleep-wake behaviour in male rats. Regul. Pept. 114 145-52 PubMed GONUTS page
  28. Chen, Q et al. () Vasopressin and oxytocin receptor mRNA expression during rat telencephalon development. Neuropeptides 34 173-80 PubMed GONUTS page
  29. 29.0 29.1 Huber, D et al. (2005) Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 308 245-8 PubMed GONUTS page
  30. 30.0 30.1 Morel, G et al. (2001) Intrauterine oxytocin system. Compartmental distribution of oxytocin and oxytocin receptors in rat endometrial epithelium. Cell Tissue Res. 304 377-82 PubMed GONUTS page
  31. Wang, D et al. (2003) Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc. Res. 57 186-94 PubMed GONUTS page
  32. Bale, TL et al. (2001) CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J. Neurosci. 21 2546-52 PubMed GONUTS page
  33. Onaka, T et al. (2003) Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus. Eur. J. Neurosci. 18 3018-26 PubMed GONUTS page
  34. Larrazolo-López, A et al. (2008) Vaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb. Neuroscience 152 585-93 PubMed GONUTS page
  35. Bealer, SL et al. (2006) Oxytocin receptor binding in the hypothalamus during gestation in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 R53-8 PubMed GONUTS page
  36. Jankowski, M et al. (2004) Oxytocin in cardiac ontogeny. Proc. Natl. Acad. Sci. U.S.A. 101 13074-9 PubMed GONUTS page
  37. Strakova, Z et al. (1998) ERK2 mediates oxytocin-stimulated PGE2 synthesis. Am. J. Physiol. 274 E634-41 PubMed GONUTS page
  38. Lukas, M et al. (2010) Maternal separation interferes with developmental changes in brain vasopressin and oxytocin receptor binding in male rats. Neuropharmacology 58 78-87 PubMed GONUTS page
  39. Kennett, JE et al. (2009) Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin. Endocrinology 150 2292-9 PubMed GONUTS page
  40. 40.0 40.1 40.2 40.3 40.4 40.5 40.6 40.7 40.8 40.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page