GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17383105

From GONUTS
Jump to: navigation, search
Citation

Thompson, MR, Callaghan, PD, Hunt, GE, Cornish, JL and McGregor, IS (2007) A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience 146:509-14

Abstract

The drug 3,4 methylenedioxymethamphetamine (MDMA; ecstasy) has a widely documented ability to increase feelings of love and closeness toward others. The present study investigated whether oxytocin, a neuropeptide involved in affiliative behavior, may play a role in this effect. A moderate (5 mg/kg, i.p.) dose of MDMA increased social interaction in male Wistar rats, primarily by increasing the amount of time rats spent lying adjacent to each other. MDMA (5 mg/kg) activated oxytocin-containing neurons in the supraoptic and paraventricular nuclei of the hypothalamus, as shown by Fos immunohistochemistry. MDMA (5 mg/kg i.p.) also increased plasma oxytocin levels and this effect was prevented by pre-treatment with the 5-HT(1A) antagonist N-[2-[4-(2-methyoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt (WAY 100,635; 1 mg/kg i.p.). The oxytocin receptor antagonist tocinoic acid (20 microg, i.c.v.) had no effect on social behavior when given alone but significantly attenuated the facilitation of social interaction produced by MDMA (5 mg/kg). The 5-HT(1A) agonist 8-hydroxy-2-(di-n-propylamino)-tetraline) (8-OH-DPAT, 0.25 mg/kg, i.p.) increased social behavior in a similar way to MDMA and this effect was also significantly attenuated by tocinoic acid. Taken together, these results suggest that oxytocin release, stimulated by MDMA through 5-HT(1A) receptors, may play a key role in the prosocial effects of MDMA and underlie some of the reinforcing effects of the drug.

Links

PubMed Online version:10.1016/j.neuroscience.2007.02.032

Keywords

8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology; Animals; Behavior, Animal/drug effects; Drug Interactions; Enzyme Inhibitors/pharmacology; Hallucinogens/pharmacology; Male; N-Methyl-3,4-methylenedioxyamphetamine/pharmacology; Oxytocin/analogs & derivatives; Oxytocin/pharmacology; Oxytocin/physiology; Piperazines/pharmacology; Proto-Oncogene Proteins c-fos/metabolism; Pyridines/pharmacology; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A/physiology; Serotonin Antagonists/pharmacology; Serotonin Receptor Agonists/pharmacology; Social Behavior

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:OXYR

involved_in

GO:0001975: response to amphetamine

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:OXYR

involved_in

GO:0035176: social behavior

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:NEU1

involved_in

GO:0001975: response to amphetamine

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.