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PMID:12504828

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Citation

Wang, D, Gutkowska, J, Marcinkiewicz, M, Rachelska, G and Jankowski, M (2003) Genistein supplementation stimulates the oxytocin system in the aorta of ovariectomized rats. Cardiovasc. Res. 57:186-94

Abstract

In the present study, we localized oxytocin (OT) and its receptor (OTR) in the rat aorta, and investigated whether genistein, an isoflavonic phytoestrogen, influences their expression in ovariectomized (OVX) rats deficient in estrogen.

Links

PubMed

Keywords

Animals; Aorta; Body Weight/drug effects; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Genistein/pharmacology; Growth Inhibitors/pharmacology; Immunohistochemistry; Nitric Oxide Synthase/analysis; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type III; Organ Size/drug effects; Ovariectomy; Oxytocin/genetics; Oxytocin/metabolism; RNA, Messenger/analysis; Rats; Rats, Sprague-Dawley; Receptors, Estrogen/analysis; Receptors, Estrogen/genetics; Receptors, Oxytocin/genetics; Receptors, Oxytocin/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stimulation, Chemical; Tunica Intima/metabolism; Uterus/anatomy & histology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:OXYR

involved_in

GO:0014070: response to organic cyclic compound

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

RAT:NEU1

involved_in

GO:0014070: response to organic cyclic compound

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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