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PMID:11764003
| Citation |
Asad, M, Shewade, DG, Koumaravelou, K, Abraham, BK, Vasu, S and Ramaswamy, S (2001) Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs. Life Sci. 70:17-24 |
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| Abstract |
The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats. Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats. The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity. However, it did not show any gastric cytoprotective effect in ethanol and indomethacin induced ulcer models but ranitidine showed protection (p<0.05) in later model. Oxytocin enhanced gastric ulcer healing in acetic acid induced chronic gastric ulcer model. The reversal of oxytocin effect by atosiban, an oxytocin receptor antagonist indicates a role for oxytocin receptors. The antiulcer activity of oxytocin can be attributed to its antisecretory effect. |
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| Keywords |
Acetic Acid/toxicity; Acute Disease; Animals; Anti-Ulcer Agents/pharmacology; Chronic Disease; Cysteamine/toxicity; Disease Models, Animal; Duodenal Ulcer/chemically induced; Duodenal Ulcer/drug therapy; Duodenal Ulcer/pathology; Duodenum/drug effects; Ethanol/toxicity; Female; Gastric Acid/secretion; Guinea Pigs; Histamine/toxicity; Indomethacin/toxicity; Male; Oxytocin/pharmacology; Pylorus/surgery; Ranitidine/pharmacology; Rats; Rats, Wistar; Stomach/drug effects; Stomach/metabolism; Stomach Ulcer/chemically induced; Stomach Ulcer/drug therapy; Stomach Ulcer/pathology; Vasotocin/analogs & derivatives; Vasotocin/therapeutic use |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060455: negative regulation of gastric acid secretion |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060455: negative regulation of gastric acid secretion |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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