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PMID:16832906

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Citation

Bealer, SL, Lipschitz, DL, Ramoz, G and Crowley, WR (2006) Oxytocin receptor binding in the hypothalamus during gestation in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291:R53-8

Abstract

Central oxytocin receptors (OTR) may be involved in adaptations of the brain oxytocin (OT) system during gestation, which are critical for systemic release of OT during parturition and lactation. We used quantitative autoradiography to determine changes in OTR binding in numerous brain sites during the course of gestation in the rat. Furthermore, to evaluate the importance of ovarian steroids in mediating pregnancy-related changes in OTR binding, we measured binding in ovariectomized animals treated with progesterone and/or estrogen, and in pregnant animals treated with exogenous progesterone during late gestation. We found that OTR binding was significantly increased in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) by midgestation (day 15) compared with control. In addition, there was a further significant increase in OTR binding in these nuclei by late gestation (day 20). The bed nucleus of the stria terminalis (BNST) and the medial preoptic area (MPOA) also showed significant gestation-associated increases in OTR binding, which were similar during mid- and late pregnancy. Treatment with exogenous progesterone throughout pregnancy did not alter the increase in OTR binding characteristic of late gestation in any of these brain sites. Finally, estrogen treatment in ovariectomized animals resulted in increased OTR binding in the SON, BNST, and MPOA, but not the PVN. These data demonstrate that OTR binding in the hypothalamus is increased during mid- and late-gestation, compared with ovariectomized control animals, which may be mediated by increased estradiol.

Links

PubMed

Keywords

Animals; Estradiol/pharmacology; Estrogens/pharmacology; Female; Gene Expression Regulation; Hypothalamus/drug effects; Hypothalamus/metabolism; Ovariectomy; Pregnancy; Progesterone/pharmacology; Progestins/pharmacology; Protein Binding; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

RAT:OXYR

involved_in

GO:0007565: female pregnancy

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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