RAT:NOS1

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Nos1 (synonyms: Bnos)
Protein Name(s)	Nitric oxide synthase, brain BNOS Constitutive NOS NC-NOS NOS type I Neuronal NOS N-NOS nNOS Peptidyl-cysteine S-nitrosylase NOS1
External Links
UniProt	P29476
EMBL	X59949 U67309
PIR	S16233
RefSeq	NP_434686.1
UniGene	Rn.10573
PDB	1B8Q 1CMI 1F20 1K2R 1K2S 1K2T 1K2U 1LZX 1LZZ 1M00 1MMV 1MMW 1OM4 1OM5 1P6H 1P6I 1P6J 1P6K 1QAU 1QAV 1QW6 1QWC 1RS6 1RS7 1TLL 1VAG 1ZVI 1ZVL 1ZZQ 1ZZR 1ZZU 2G6H 2G6I 2G6J 2G6K 2G6L 2G6M 2G6N 2HX3 2HX4 3B3M 3B3N 3B3O 3B3P 3DQR 3FC5 3HSN 3HSO 3HSP 3JT3 3JT4 3JT5 3JT6 3JT7 3JT8 3JT9 3JTA 3JWS 3JWT 3JWU 3JWV 3JX0 3JX1 3JX2 3JX3 3JX4 3JX5 3JX6 3N2R 3N5V 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N66 3N67 3N68 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNY 3NNZ 3PNE 3PNF 3PNG 3Q99 3Q9A 3RQJ 3RQK 3RQL 3RQM 3RQN 3SVP 3SVQ 3TYL 3TYM 3TYN 3TYO 3UFO 3UFP 3UFQ 3UFR 3UFS 3UFT 3UFU 3UFV 3UFW 4C39 4CAM 4CAN 4CAO 4CAP 4CAQ 4CDT 4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTX 4CX3 4CX4 4CX5 4CX6 4EUX 4FVW 4FVX 4FVY 4FVZ 4FW0 4GQE 4HOP 4IMS 4IMT 4IMU 4IMW 4JSE 4JSF 4JSG 4JSH 4JSI 4JSJ 4K5D 4K5E 4K5F 4K5G 4KCH 4KCI 4KCJ 4KCK 4KCL 4KCM 4KCN 4KCO 4LUX 4UPM 4UPN 4UPO 4UPP
PDBsum	1B8Q 1CMI 1F20 1K2R 1K2S 1K2T 1K2U 1LZX 1LZZ 1M00 1MMV 1MMW 1OM4 1OM5 1P6H 1P6I 1P6J 1P6K 1QAU 1QAV 1QW6 1QWC 1RS6 1RS7 1TLL 1VAG 1ZVI 1ZVL 1ZZQ 1ZZR 1ZZU 2G6H 2G6I 2G6J 2G6K 2G6L 2G6M 2G6N 2HX3 2HX4 3B3M 3B3N 3B3O 3B3P 3DQR 3FC5 3HSN 3HSO 3HSP 3JT3 3JT4 3JT5 3JT6 3JT7 3JT8 3JT9 3JTA 3JWS 3JWT 3JWU 3JWV 3JX0 3JX1 3JX2 3JX3 3JX4 3JX5 3JX6 3N2R 3N5V 3N5W 3N5X 3N5Y 3N5Z 3N60 3N61 3N62 3N63 3N64 3N65 3N66 3N67 3N68 3N69 3N6A 3N6B 3N6C 3N6D 3N6E 3N6F 3N6G 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNY 3NNZ 3PNE 3PNF 3PNG 3Q99 3Q9A 3RQJ 3RQK 3RQL 3RQM 3RQN 3SVP 3SVQ 3TYL 3TYM 3TYN 3TYO 3UFO 3UFP 3UFQ 3UFR 3UFS 3UFT 3UFU 3UFV 3UFW 4C39 4CAM 4CAN 4CAO 4CAP 4CAQ 4CDT 4CTP 4CTQ 4CTR 4CTT 4CTU 4CTV 4CTW 4CTX 4CX3 4CX4 4CX5 4CX6 4EUX 4FVW 4FVX 4FVY 4FVZ 4FW0 4GQE 4HOP 4IMS 4IMT 4IMU 4IMW 4JSE 4JSF 4JSG 4JSH 4JSI 4JSJ 4K5D 4K5E 4K5F 4K5G 4KCH 4KCI 4KCJ 4KCK 4KCL 4KCM 4KCN 4KCO 4LUX 4UPM 4UPN 4UPO 4UPP
ProteinModelPortal	P29476
SMR	P29476
BioGrid	246738
IntAct	P29476
MINT	MINT-89230
STRING	10116.ENSRNOP00000062735
BindingDB	P29476
ChEMBL	CHEMBL3048
GuidetoPHARMACOLOGY	1251
PhosphoSite	P29476
PaxDb	P29476
PRIDE	P29476
GeneID	24598
KEGG	rno:24598
UCSC	RGD:3184
CTD	4842
RGD	3184
eggNOG	COG4362
HOGENOM	HOG000220884
HOVERGEN	HBG000159
InParanoid	P29476
KO	K13240
PhylomeDB	P29476
SABIO-RK	P29476
EvolutionaryTrace	P29476
NextBio	603800
Proteomes	UP000002494
Genevestigator	P29476
GO	GO:0042582 GO:0005737 GO:0005829 GO:0030425 GO:0043197 GO:0016020 GO:0005741 GO:0005739 GO:0031965 GO:0005634 GO:0048471 GO:0001917 GO:0005886 GO:0014069 GO:0043234 GO:0042383 GO:0045202 GO:0012506 GO:0016597 GO:0051117 GO:0046870 GO:0005516 GO:0019899 GO:0050660 GO:0010181 GO:0020037 GO:0044325 GO:0005506 GO:0050661 GO:0003958 GO:0004517 GO:0042803 GO:0097110 GO:0017080 GO:0007568 GO:0006527 GO:0048148 GO:0071872 GO:0071260 GO:0007565 GO:0006936 GO:0043066 GO:0045776 GO:0008285 GO:0051481 GO:0045822 GO:0046676 GO:0033137 GO:0045906 GO:0006809 GO:0007263 GO:0018119 GO:0031284 GO:1900273 GO:1901216 GO:1902307 GO:0045909 GO:0008016 GO:0051930 GO:0014823 GO:0043627 GO:0045471 GO:0009408 GO:0001666 GO:0010288 GO:0032496 GO:0035094 GO:0071731 GO:0031667 GO:0014070 GO:0010243 GO:0043434 GO:0033197
Gene3D	1.20.990.10 2.30.42.10 3.40.50.360 3.90.340.10
InterPro	IPR003097 IPR017927 IPR001094 IPR008254 IPR001709 IPR029039 IPR023173 IPR012144 IPR004030 IPR001433 IPR001478 IPR017938
Pfam	PF00667 PF00258 PF00175 PF02898 PF00595
PIRSF	PIRSF000333
PRINTS	PR00369 PR00371
SMART	SM00228
SUPFAM	SSF50156 SSF52218 SSF56512 SSF63380
PROSITE	PS51384 PS50902 PS60001 PS50106

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:11590170^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045184	establishment of protein localization	PMID:11590170^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11590170^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	PMID:11590170^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z2F5	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:12388603^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(GO:0060076) part_of:(CL:0000598) part_of:(UBERON:0003881)	Seeded From UniProt	complete
involved_in	GO:0071872	cellular response to epinephrine stimulus	PMID:19278978^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002495)	Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:19278978^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002495)	Seeded From UniProt	complete
involved_in	GO:0033137	negative regulation of peptidyl-serine phosphorylation	PMID:19278978^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002495)	Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	PMID:11591728^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23634	F		Seeded From UniProt	complete
involved_in	GO:1902307	positive regulation of sodium ion transmembrane transport	PMID:18591664^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:18591664^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13424	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:17027776^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046870	cadmium ion binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:18591664^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14524	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18591664^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:7527495^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018119	peptidyl-cysteine S-nitrosylation	PMID:18591664^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:18591664^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:18591664^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:1383204^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001917	photoreceptor inner segment	PMID:17027776^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:16276418^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:12388603^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099092	postsynaptic density, intracellular component	PMID:12388603^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:12388603^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12388603^[2]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:12388603^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:23062100^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	PMID:23579428^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097755	positive regulation of blood vessel diameter	PMID:17291465^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071731	response to nitric oxide	PMID:20473255^[14]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:23619128^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070402	NADPH binding	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061875	negative regulation of hepatic stellate cell contraction	PMID:10727442^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051930	regulation of sensory perception of pain	PMID:17101217^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051481	negative regulation of cytosolic calcium ion concentration	PMID:23172925^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	PMID:23579428^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	PMID:17130471^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045906	negative regulation of vasoconstriction	PMID:23640592^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045822	negative regulation of heart contraction	PMID:15331368^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:15331368^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:16737454^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	PMID:12581836^[24]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:12526033^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:17553983^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:14752097^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	PMID:20181617^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20596694^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23832698^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17347455^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0042582	azurophil granule	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:21050840^[33]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034760	negative regulation of iron ion transmembrane transport	PMID:14752097^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033197	response to vitamin E	PMID:17200156^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:20724006^[35]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031667	response to nutrient levels	PMID:20079408^[36]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:12526033^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030141	secretory granule	PMID:11375331^[37]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:16537391^[38]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:2151	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21490139^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014823	response to activity	PMID:19793134^[40]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	PMID:17611313^[41]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:11226670^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21448354^[43]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010288	response to lead ion	PMID:19524414^[44]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010243	response to organonitrogen compound	PMID:17310378^[45]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	PMID:16950411^[46]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:20338922^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10954720^[48]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008016	regulation of heart contraction	PMID:16537391^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:17683464^[49]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:23283939^[50]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:20630934^[51]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:12727317^[52]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:16361261^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:12526033^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16361261^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12526033^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:20529840^[54]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:17029414^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:16387842^[32]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:14966111^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:17442632^[55]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0098924	retrograde trans-synaptic signaling by nitric oxide	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 PANTHER:PTN000454042	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0045776	negative regulation of blood pressure	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453988 RGD:3184	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 ZFIN:ZDB-GENE-040305-1	P		Seeded From UniProt	complete
involved_in	GO:0031284	positive regulation of guanylate cyclase activity	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 UniProtKB:P29473 UniProtKB:P29474	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97744 PANTHER:PTN000453956 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000454042 RGD:3184	C		Seeded From UniProt	complete
part_of	GO:0012506	vesicle membrane	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10191 MGI:MGI:97361 PANTHER:PTN000453956 RGD:3184 RGD:68335 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:Q9UBK8 UniProtKB:Q9UHB4	F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002322100 RGD:3185	P		Seeded From UniProt	complete
involved_in	GO:0007263	nitric oxide mediated signal transduction	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 ZFIN:ZDB-GENE-001101-1	P		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
involved_in	GO:0006527	arginine catabolic process	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97361 PANTHER:PTN001066032 RGD:3184 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P35228	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001066032 RGD:3184 RGD:3186 UniProtKB:P29475	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453956 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228 UniProtKB:Q9SB48 UniProtKB:Q9UHB4	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453765 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P35228	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186	C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011676 MGI:MGI:97360 MGI:MGI:97361 MGI:MGI:97362 PANTHER:PTN001066032 RGD:3184 RGD:3185 RGD:3186 UniProtKB:P29473 UniProtKB:P29474 UniProtKB:P29475 UniProtKB:P35228	F		Seeded From UniProt	complete
enables	GO:0003958	NADPH-hemoprotein reductase activity	PMID:21873635^[56]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000453763 PomBase:SPBC29A10.01 RGD:68335 SGD:S000001084 TAIR:locus:2128951 UniProtKB:A0A1D8PLR7 UniProtKB:O08336 UniProtKB:O08394 UniProtKB:P16435 UniProtKB:Q9UBK8	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:16537391^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0006809	nitric oxide biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004030 InterPro:IPR012144 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0010181	FMN binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR008254 InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR017927 InterPro:IPR023173	F		Seeded From UniProt	complete
enables	GO:0020037	heme binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
enables	GO:0050661	NADP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012144	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001094 InterPro:IPR001433 InterPro:IPR001709 InterPro:IPR003097 InterPro:IPR004030 InterPro:IPR017927 InterPro:IPR023173 InterPro:IPR036119	P		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.13.39	F		Seeded From UniProt	complete
enables	GO:0004517	nitric-oxide synthase activity	PMID:12526033^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0238	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Riefler, GM & Firestein, BL (2001) Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J. Biol. Chem. 276 48262-8 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Burette, A et al. (2002) Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. J. Neurosci. 22 8961-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Mohamed, TM et al. (2009) Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J. Biol. Chem. 284 12091-8 PubMed GONUTS page
↑ Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Ueda, K et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 105 9355-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Konas, DW et al. (2006) Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry 45 12596-609 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Stuehr, DJ & Ikeda-Saito, M (1992) Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. J. Biol. Chem. 267 20547-50 PubMed GONUTS page
↑ ^8.0 ^8.1 Vidal, L et al. (2006) Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol. Brain Res. Bull. 70 406-13 PubMed GONUTS page
↑ Kobzik, L et al. (1994) Nitric oxide in skeletal muscle. Nature 372 546-8 PubMed GONUTS page
↑ Ward, ME et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J. Clin. Invest. 115 3128-39 PubMed GONUTS page
↑ Cui, W et al. (2013) The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br. J. Pharmacol. 168 1201-14 PubMed GONUTS page
↑ ^12.0 ^12.1 Gabach, LA et al. (2013) Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Psychopharmacology (Berl.) 229 41-50 PubMed GONUTS page
↑ Talman, WT & Nitschke Dragon, D (2007) Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain Res. 1139 126-32 PubMed GONUTS page
↑ Cattano, D et al. (2010) Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Minerva Anestesiol 76 420-4 PubMed GONUTS page
↑ Dick, AS et al. (2013) Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Free Radic. Biol. Med. 61 310-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Panda, K et al. (2004) A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. J. Biol. Chem. 279 18323-33 PubMed GONUTS page
↑ Yu, Q et al. (2000) Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J. Clin. Invest. 105 741-8 PubMed GONUTS page
↑ Liu, W et al. (2006) Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia. Neurosci. Lett. 410 174-7 PubMed GONUTS page
↑ Li, D et al. (2013) Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. Hypertension 61 202-7 PubMed GONUTS page
↑ Lajoix, AD et al. (2006) Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Diabetes 55 3279-88 PubMed GONUTS page
↑ Jendzjowsky, NG & DeLorey, DS (2013) Role of neuronal nitric oxide in the inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle of healthy rats. J. Appl. Physiol. 115 97-106 PubMed GONUTS page
↑ ^22.0 ^22.1 Wang, Y et al. (2005) Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Am. J. Physiol. Heart Circ. Physiol. 288 H205-13 PubMed GONUTS page
↑ Krecsmarik, M et al. (2006) Chronic ethanol exposure impairs neuronal nitric oxide synthase in the rat intestine. Alcohol. Clin. Exp. Res. 30 967-73 PubMed GONUTS page
↑ Naassila, M et al. (2003) Chronic ethanol exposure differentially regulates NOS1 mRNA levels depending on rat brain area. Neurosci. Lett. 338 221-4 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 Batista, CM et al. (2003) Nitrergic dendrites in the superficial layers of the rat superior colliculus: retinal afferents and alternatively spliced isoforms in normal and deafferented animals. J. Neurosci. Res. 71 455-61 PubMed GONUTS page
↑ d'Anglemont de Tassigny, X et al. (2007) Coupling of neuronal nitric oxide synthase to NMDA receptors via postsynaptic density-95 depends on estrogen and contributes to the central control of adult female reproduction. J. Neurosci. 27 6103-14 PubMed GONUTS page
↑ ^27.0 ^27.1 Shang, T et al. (2004) 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. J. Biol. Chem. 279 19099-112 PubMed GONUTS page
↑ Garrel, G et al. (2010) Sustained gonadotropin-releasing hormone stimulation mobilizes the cAMP/PKA pathway to induce nitric oxide synthase type 1 expression in rat pituitary cells in vitro and in vivo at proestrus. Biol. Reprod. 82 1170-9 PubMed GONUTS page
↑ Bachar, E et al. (2010) Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis. Diabetologia 53 2177-87 PubMed GONUTS page
↑ Sharma, NM et al. (2013) Angiotensin II-mediated posttranslational modification of nNOS in the PVN of rats with CHF: role for PIN. Am. J. Physiol. Heart Circ. Physiol. 305 H843-55 PubMed GONUTS page
↑ Gangula, PR et al. (2007) Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G725-33 PubMed GONUTS page
↑ ^32.0 ^32.1 ^32.2 ^32.3 ^32.4 ^32.5 Saini, R et al. (2006) Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies. J. Leukoc. Biol. 79 519-28 PubMed GONUTS page
↑ Keser, A et al. (2011) Hippocampal neuronal nitric oxide synthase (nNOS) is regulated by nicotine and stress in female but not in male rats. Brain Res. 1368 134-42 PubMed GONUTS page
↑ Tain, YL et al. (2007) Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. Am. J. Physiol. Renal Physiol. 292 F1404-10 PubMed GONUTS page
↑ Yao, SY et al. (2010) In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes. J. Neuroimmunol. 229 146-56 PubMed GONUTS page
↑ Zhang, Y et al. (2010) Perinatal food restriction impaired spatial learning and memory behavior and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring. Toxicol. Lett. 193 167-72 PubMed GONUTS page
↑ Lajoix, AD et al. (2001) A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Diabetes 50 1311-23 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 Steppan, J et al. (2006) Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc. Natl. Acad. Sci. U.S.A. 103 4759-64 PubMed GONUTS page
↑ Hyndman, KA et al. (2011) Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Am. J. Physiol. Renal Physiol. 301 F118-24 PubMed GONUTS page
↑ Ozbek, E et al. (2010) The effect of regular exercise on penile nitric oxide synthase expression in rats. Int. J. Androl. 33 623-8 PubMed GONUTS page
↑ Qi, CF et al. (2007) [Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 32 396-400 PubMed GONUTS page
↑ Wyneken, U et al. (2001) Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Neuroscience 102 65-74 PubMed GONUTS page
↑ Talapka, P et al. (2011) Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum. World J. Gastroenterol. 17 1026-9 PubMed GONUTS page
↑ Nava-Ruíz, C et al. (2010) Nitric oxide synthase immunolocalization and expression in the rat hippocampus after sub-acute lead acetate exposure in rats. Exp. Toxicol. Pathol. 62 311-6 PubMed GONUTS page
↑ Klawitter, V et al. (2007) Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide. Exp Brain Res 180 139-52 PubMed GONUTS page
↑ Cheng, BC et al. (2007) Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Neuropharmacology 52 297-305 PubMed GONUTS page
↑ Pelletier, AM et al. (2010) Neuronal nitric oxide inhibits intestinal smooth muscle growth. Am. J. Physiol. Gastrointest. Liver Physiol. 298 G896-907 PubMed GONUTS page
↑ Hemmens, B et al. (2000) Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. J. Biol. Chem. 275 35786-91 PubMed GONUTS page
↑ Gao, BH et al. (2007) Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways. Andrologia 39 146-50 PubMed GONUTS page
↑ Cunningham, MW Jr et al. (2013) Renal redox response to normal pregnancy in the rat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304 R443-9 PubMed GONUTS page
↑ Smith, CA et al. (2010) Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases. Am. J. Physiol. Renal Physiol. 299 F830-6 PubMed GONUTS page
↑ Leimert, M & Blottner, D (2003) Neuronal nitric oxide synthase (bNOS) messenger RNA and protein expression in developing rat brainstem nuclei. Neurosci. Lett. 342 57-60 PubMed GONUTS page
↑ ^53.0 ^53.1 Franco, MC et al. (2006) Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase. J. Biol. Chem. 281 4779-86 PubMed GONUTS page
↑ Tejero, J et al. (2010) A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. J. Biol. Chem. 285 25941-9 PubMed GONUTS page
↑ Huang, J et al. (2007) Chronic intermittent hypoxia modulates nNOS mRNA and protein expression in the rat hypothalamus. Respir Physiol Neurobiol 158 30-8 PubMed GONUTS page
↑ ^56.00 ^56.01 ^56.02 ^56.03 ^56.04 ^56.05 ^56.06 ^56.07 ^56.08 ^56.09 ^56.10 ^56.11 ^56.12 ^56.13 ^56.14 ^56.15 ^56.16 ^56.17 ^56.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11590170-1] 1.0 ^1.1 ^1.2 ^1.3 Riefler, GM & Firestein, BL (2001) Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J. Biol. Chem. 276 48262-8 PubMed GONUTS page

[PMID:12388603-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Burette, A et al. (2002) Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. J. Neurosci. 22 8961-70 PubMed GONUTS page

[PMID:19278978-3] 3.0 ^3.1 ^3.2 Mohamed, TM et al. (2009) Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. J. Biol. Chem. 284 12091-8 PubMed GONUTS page

[PMID:11591728-4] Schuh, K et al. (2001) The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. J. Cell Biol. 155 201-5 PubMed GONUTS page

[PMID:18591664-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Ueda, K et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc. Natl. Acad. Sci. U.S.A. 105 9355-60 PubMed GONUTS page

[PMID:17029414-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Konas, DW et al. (2006) Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Biochemistry 45 12596-609 PubMed GONUTS page

[PMID:1383204-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Stuehr, DJ & Ikeda-Saito, M (1992) Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. J. Biol. Chem. 267 20547-50 PubMed GONUTS page

[PMID:17027776-8] 8.0 ^8.1 Vidal, L et al. (2006) Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol. Brain Res. Bull. 70 406-13 PubMed GONUTS page

[PMID:7527495-9] Kobzik, L et al. (1994) Nitric oxide in skeletal muscle. Nature 372 546-8 PubMed GONUTS page

[PMID:16276418-10] Ward, ME et al. (2005) Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. J. Clin. Invest. 115 3128-39 PubMed GONUTS page

[PMID:23062100-11] Cui, W et al. (2013) The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br. J. Pharmacol. 168 1201-14 PubMed GONUTS page

[PMID:23579428-12] 12.0 ^12.1 Gabach, LA et al. (2013) Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Psychopharmacology (Berl.) 229 41-50 PubMed GONUTS page

[PMID:17291465-13] Talman, WT & Nitschke Dragon, D (2007) Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain Res. 1139 126-32 PubMed GONUTS page

[PMID:20473255-14] Cattano, D et al. (2010) Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Minerva Anestesiol 76 420-4 PubMed GONUTS page

[PMID:23619128-15] Dick, AS et al. (2013) Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Free Radic. Biol. Med. 61 310-9 PubMed GONUTS page

[PMID:14966111-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Panda, K et al. (2004) A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. J. Biol. Chem. 279 18323-33 PubMed GONUTS page

[PMID:10727442-17] Yu, Q et al. (2000) Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J. Clin. Invest. 105 741-8 PubMed GONUTS page

[PMID:17101217-18] Liu, W et al. (2006) Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia. Neurosci. Lett. 410 174-7 PubMed GONUTS page

[PMID:23172925-19] Li, D et al. (2013) Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. Hypertension 61 202-7 PubMed GONUTS page

[PMID:17130471-20] Lajoix, AD et al. (2006) Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Diabetes 55 3279-88 PubMed GONUTS page

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[PMID:17200156-34] Tain, YL et al. (2007) Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. Am. J. Physiol. Renal Physiol. 292 F1404-10 PubMed GONUTS page

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[PMID:20079408-36] Zhang, Y et al. (2010) Perinatal food restriction impaired spatial learning and memory behavior and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring. Toxicol. Lett. 193 167-72 PubMed GONUTS page

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[PMID:16950411-46] Cheng, BC et al. (2007) Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Neuropharmacology 52 297-305 PubMed GONUTS page

[PMID:20338922-47] Pelletier, AM et al. (2010) Neuronal nitric oxide inhibits intestinal smooth muscle growth. Am. J. Physiol. Gastrointest. Liver Physiol. 298 G896-907 PubMed GONUTS page

[PMID:10954720-48] Hemmens, B et al. (2000) Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. J. Biol. Chem. 275 35786-91 PubMed GONUTS page

[PMID:17683464-49] Gao, BH et al. (2007) Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways. Andrologia 39 146-50 PubMed GONUTS page

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[PMID:20529840-54] Tejero, J et al. (2010) A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. J. Biol. Chem. 285 25941-9 PubMed GONUTS page

[PMID:17442632-55] Huang, J et al. (2007) Chronic intermittent hypoxia modulates nNOS mRNA and protein expression in the rat hypothalamus. Respir Physiol Neurobiol 158 30-8 PubMed GONUTS page

[PMID:21873635-56] 56.00 ^56.01 ^56.02 ^56.03 ^56.04 ^56.05 ^56.06 ^56.07 ^56.08 ^56.09 ^56.10 ^56.11 ^56.12 ^56.13 ^56.14 ^56.15 ^56.16 ^56.17 ^56.18 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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RAT:NOS1

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