PMID:12727317

Citation	Leimert, M and Blottner, D (2003) Neuronal nitric oxide synthase (bNOS) messenger RNA and protein expression in developing rat brainstem nuclei. Neurosci. Lett. 342:57-60
Abstract	Neuronal nitric oxide synthase (bNOS) messenger RNA expression and immunoreactivity were mapped in series of cryosections through the developing rat brainstem nuclei. Between embryonic day E16 and postnatal day P16, brainstem nuclei expressed both bNOS messenger RNA (mRNA) in situ hybridization signals and protein immunoreactivity. However, NOS mRNA signals were absent from the Edinger Westphal, facial or motory trigeminal nucleus. Strong patterns of mRNA signals and immunoreactivity occurred in neurons located in the substantia nigra pars compacta and the laterodorsal tegmental nuclei. Between E24 and P16, altered patterns of bNOS mRNA positive and immunoreactive neurons, e.g. superior and inferior colliculi, raphe nuclei, solitary tract or pontine nucleus were documented. Altered NOS expression patterns thus may reflect developmental processes within distinct neuronal populations such as cell phenotype discrimination or synaptogenesis within efferent or afferent brainstem pathways. The NOS/NO system therefore appears to be a modulator for intra-/intercellular adjustment processes in normal development.
Links	PubMed
Keywords	Animals; Animals, Newborn; Brain Stem/chemistry; Brain Stem/growth & development; Brain Stem/metabolism; Immunohistochemistry; In Situ Hybridization; Neurons/enzymology; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type I; RNA, Messenger/metabolism; Rats; Rats, Wistar
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
RAT:NOS1	involved_in	GO:0007420: brain development	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete

References

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