RAT:MK01

Species (Taxon ID)	Rattus norvegicus (Rat). (10116)
Gene Name(s)	Mapk1 (synonyms: Erk2, Mapk, Prkm1)
Protein Name(s)	Mitogen-activated protein kinase 1 MAP kinase 1 MAPK 1 ERT1 Extracellular signal-regulated kinase 2 ERK-2 MAP kinase isoform p42 p42-MAPK Mitogen-activated protein kinase 2 MAP kinase 2 MAPK 2
External Links
UniProt	P63086
EMBL	M64300
PIR	A40033
RefSeq	NP_446294.1 XP_006248720.1 XP_006248721.1 XP_008767070.1
UniGene	Rn.34914
PDB	1ERK 1GOL 2ERK 2FYS 2GPH 2Z7L 3C9W 3ERK 3O71 3QYI 3QYW 3QYZ 3R63 3ZU7 3ZUV 4ERK 4GSB 4GT3 4GVA 4I5H 4N4S 4QYY
PDBsum	1ERK 1GOL 2ERK 2FYS 2GPH 2Z7L 3C9W 3ERK 3O71 3QYI 3QYW 3QYZ 3R63 3ZU7 3ZUV 4ERK 4GSB 4GT3 4GVA 4I5H 4N4S 4QYY
ProteinModelPortal	P63086
SMR	P63086
BioGrid	250505
DIP	DIP-29117N
IntAct	P63086
MINT	MINT-100037
BindingDB	P63086
ChEMBL	CHEMBL2111356
PhosphoSite	P63086
World-2DPAGE	0004:P63086
PaxDb	P63086
PRIDE	P63086
Ensembl	ENSRNOT00000002533
GeneID	116590
KEGG	rno:116590
CTD	5594
RGD	70500
eggNOG	COG0515
GeneTree	ENSGT00550000074298
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P63086
KO	K04371
OMA	VCSAYDR
OrthoDB	EOG7M3J0K
PhylomeDB	P63086
BRENDA	2.7.11.24
Reactome	REACT_194748 REACT_195028 REACT_195202 REACT_196231 REACT_196390 REACT_196391 REACT_196425 REACT_196755 REACT_198995 REACT_203770 REACT_215142 REACT_216489 REACT_222166 REACT_230341 REACT_239163 REACT_240952 REACT_251180 REACT_253470 REACT_254856 REACT_259173 REACT_260564 REACT_262403 REACT_262448 REACT_262886
EvolutionaryTrace	P63086
NextBio	304409
PRO	PR:P63086
Proteomes	UP000002494
Genevestigator	P63086
GO	GO:0030424 GO:0005901 GO:0005737 GO:0005856 GO:0005829 GO:0032839 GO:0005769 GO:0070062 GO:0005925 GO:0005794 GO:0005770 GO:0005815 GO:0005739 GO:0072686 GO:0005654 GO:0005634 GO:0043204 GO:0043234 GO:0031143 GO:0005524 GO:0016301 GO:0004707 GO:0031435 GO:0019901 GO:0004674 GO:0008353 GO:0008134 GO:0006915 GO:0050853 GO:0072584 GO:0007049 GO:0006974 GO:0097011 GO:0071310 GO:0019858 GO:0038127 GO:0070371 GO:0035556 GO:0060716 GO:0031663 GO:0033598 GO:0000165 GO:0000189 GO:0045596 GO:0009887 GO:0018105 GO:0018107 GO:0030335 GO:0008284 GO:0010800 GO:0045893 GO:0045727 GO:0006468 GO:0051493 GO:2000641 GO:0090170 GO:0031647 GO:0032872 GO:0070849 GO:0043627 GO:0043330 GO:0009636 GO:0019233 GO:0007165 GO:0050852
InterPro	IPR011009 IPR003527 IPR008349 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01770
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm	PMID:24567387^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:24567387^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:12944431^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:24567387^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0015966	diadenosine tetraphosphate biosynthetic process	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:19524539^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	C	exists_during:(GO:0000236)\|exists_during:(GO:0000089)	Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28482	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	P	has_input:(UniProtKB:Q91790) happens_during:(GO:0007143)	Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	PMID:11356865^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63085	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	C	exists_during:(GO:0051329)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P28482	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:7889942^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:7889942^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:11404397^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q05941	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002037)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:7478291^[7]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:12487375^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	PMID:26884868^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	PMID:21248290^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:15027896^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	PMID:11751611^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	PMID:9714150^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:12072413^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15781236^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	PMID:9714150^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	PMID:12049732^[16]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620966	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:9714150^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:15917991^[17]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:16943189^[18]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:1587390	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16955078^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:17651772^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:15583728^[21]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:10363932^[22]	ECO:0000353	physical interaction evidence used in manual assertion	RGD:620036	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:28515230^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:11714707^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:26950759^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15027896^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:9779826^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17150373^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:15027896^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:16955078^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:15027896^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15027896^[11]	ECO:0000305	curator inference used in manual assertion	GO:0004707	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	PMID:26950759^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:17310240^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[29]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:7768935^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:7768935^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004708	P		Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	F		Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P28482 ensembl:ENSP00000215832	F		Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0061308	cardiac neural crest cell development involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0042473	outer ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0033598	mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0030641	regulation of cellular pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0019858	cytosine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008349	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008349 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008349	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090170	regulation of Golgi inheritance	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051493	regulation of cytoskeleton organization	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19565474^[31] Reactome:R-NUL-997411	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19565474^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9779826^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:11687663^[32]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9779826^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:9779826^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-3245934	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Ogata, T et al. (2014) MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. Proc. Natl. Acad. Sci. U.S.A. 111 3811-6 PubMed GONUTS page
↑ Terret, ME et al. (2003) DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes. Development 130 5169-77 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yannay-Cohen, N et al. (2009) LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol. Cell 34 603-11 PubMed GONUTS page
↑ Karim, F et al. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. 21 3771-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Gille, H et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14 951-62 PubMed GONUTS page
↑ Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Suzuki, T et al. (1995) ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain. Neurosci. Res. 22 277-85 PubMed GONUTS page
↑ Ranganna, K et al. (2002) Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells. Mol. Cell. Biochem. 240 83-98 PubMed GONUTS page
↑ Zhao, J et al. (2015) MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway. Int J Clin Exp Pathol 8 15947-53 PubMed GONUTS page
↑ Vallejo, G et al. (2011) Ovarian steroid receptors and activated MAPK in the regional decidualization in rats. Biol. Reprod. 84 1063-71 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gorin, Y et al. (2004) Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem. J. 381 231-9 PubMed GONUTS page
↑ Nilsen, J & Brinton, RD (2002) Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143 205-12 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Flood, DG et al. (1998) Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. J. Comp. Neurol. 398 373-92 PubMed GONUTS page
↑ Schwartz, Z et al. (2002) 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143 2775-86 PubMed GONUTS page
↑ Kim, S & Pak, Y (2005) Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Biochem. Biophys. Res. Commun. 330 88-96 PubMed GONUTS page
↑ Lu, Z et al. (2002) The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9 945-56 PubMed GONUTS page
↑ Lo, IC et al. (2005) Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration. J. Biomed. Sci. 12 377-88 PubMed GONUTS page
↑ Fiedler, B et al. (2006) cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. J. Biol. Chem. 281 32831-40 PubMed GONUTS page
↑ ^19.0 ^19.1 Chen, S et al. (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J. Cereb. Blood Flow Metab. 27 939-49 PubMed GONUTS page
↑ Marin-Kuan, M et al. (2007) MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol. 224 174-81 PubMed GONUTS page
↑ Peng, CY et al. (2004) The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury. Thromb. Haemost. 92 1232-9 PubMed GONUTS page
↑ Liu, YZ et al. (1999) CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. Neuroreport 10 1239-43 PubMed GONUTS page
↑ Isensee, J et al. (2017) Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. J. Cell. Sci. 130 2134-2146 PubMed GONUTS page
↑ Takagi, N et al. (2002) Altered extracellular signal-regulated kinase signal transduction by the muscarinic acetylcholine and metabotropic glutamate receptors after cerebral ischemia. J. Biol. Chem. 277 6382-90 PubMed GONUTS page
↑ ^25.0 ^25.1 McReynolds, AC et al. (2016) Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding. Biochemistry 55 1909-17 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 Kim, SO et al. (1998) Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J. Cell. Biochem. 71 286-301 PubMed GONUTS page
↑ Watson, PM et al. (2007) Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol. Cell. Neurosci. 34 147-54 PubMed GONUTS page
↑ Santos, SD et al. (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9 324-30 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 ^29.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^30.0 ^30.1 Taylor, GA et al. (1995) Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J. Biol. Chem. 270 13341-7 PubMed GONUTS page
↑ ^31.00 ^31.01 ^31.02 ^31.03 ^31.04 ^31.05 ^31.06 ^31.07 ^31.08 ^31.09 ^31.10 ^31.11 ^31.12 ^31.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page
↑ Bi, R et al. (2001) Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Proc. Natl. Acad. Sci. U.S.A. 98 13391-5 PubMed GONUTS page

[PMID:24567387-1] 1.0 ^1.1 ^1.2 Ogata, T et al. (2014) MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. Proc. Natl. Acad. Sci. U.S.A. 111 3811-6 PubMed GONUTS page

[PMID:12944431-2] Terret, ME et al. (2003) DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes. Development 130 5169-77 PubMed GONUTS page

[PMID:19524539-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Yannay-Cohen, N et al. (2009) LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol. Cell 34 603-11 PubMed GONUTS page

[PMID:11356865-4] Karim, F et al. (2001) Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice. J. Neurosci. 21 3771-9 PubMed GONUTS page

[PMID:7889942-5] 5.0 ^5.1 Gille, H et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14 951-62 PubMed GONUTS page

[PMID:11404397-6] Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

[PMID:7478291-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Suzuki, T et al. (1995) ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain. Neurosci. Res. 22 277-85 PubMed GONUTS page

[PMID:12487375-8] Ranganna, K et al. (2002) Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells. Mol. Cell. Biochem. 240 83-98 PubMed GONUTS page

[PMID:26884868-9] Zhao, J et al. (2015) MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway. Int J Clin Exp Pathol 8 15947-53 PubMed GONUTS page

[PMID:21248290-10] Vallejo, G et al. (2011) Ovarian steroid receptors and activated MAPK in the regional decidualization in rats. Biol. Reprod. 84 1063-71 PubMed GONUTS page

[PMID:15027896-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gorin, Y et al. (2004) Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. Biochem. J. 381 231-9 PubMed GONUTS page

[PMID:11751611-12] Nilsen, J & Brinton, RD (2002) Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 143 205-12 PubMed GONUTS page

[PMID:9714150-13] 13.0 ^13.1 ^13.2 Flood, DG et al. (1998) Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. J. Comp. Neurol. 398 373-92 PubMed GONUTS page

[PMID:12072413-14] Schwartz, Z et al. (2002) 1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase. Endocrinology 143 2775-86 PubMed GONUTS page

[PMID:15781236-15] Kim, S & Pak, Y (2005) Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells. Biochem. Biophys. Res. Commun. 330 88-96 PubMed GONUTS page

[PMID:12049732-16] Lu, Z et al. (2002) The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9 945-56 PubMed GONUTS page

[PMID:15917991-17] Lo, IC et al. (2005) Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration. J. Biomed. Sci. 12 377-88 PubMed GONUTS page

[PMID:16943189-18] Fiedler, B et al. (2006) cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes. J. Biol. Chem. 281 32831-40 PubMed GONUTS page

[PMID:16955078-19] 19.0 ^19.1 Chen, S et al. (2007) Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury. J. Cereb. Blood Flow Metab. 27 939-49 PubMed GONUTS page

[PMID:17651772-20] Marin-Kuan, M et al. (2007) MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma. Toxicol. Appl. Pharmacol. 224 174-81 PubMed GONUTS page

[PMID:15583728-21] Peng, CY et al. (2004) The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury. Thromb. Haemost. 92 1232-9 PubMed GONUTS page

[PMID:10363932-22] Liu, YZ et al. (1999) CBP associates with the p42/p44 MAPK enzymes and is phosphorylated following NGF treatment. Neuroreport 10 1239-43 PubMed GONUTS page

[PMID:28515230-23] Isensee, J et al. (2017) Crosstalk from cAMP to ERK1/2 emerges during postnatal maturation of nociceptive neurons and is maintained during aging. J. Cell. Sci. 130 2134-2146 PubMed GONUTS page

[PMID:11714707-24] Takagi, N et al. (2002) Altered extracellular signal-regulated kinase signal transduction by the muscarinic acetylcholine and metabotropic glutamate receptors after cerebral ischemia. J. Biol. Chem. 277 6382-90 PubMed GONUTS page

[PMID:26950759-25] 25.0 ^25.1 McReynolds, AC et al. (2016) Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding. Biochemistry 55 1909-17 PubMed GONUTS page

[PMID:9779826-26] 26.0 ^26.1 ^26.2 ^26.3 Kim, SO et al. (1998) Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. J. Cell. Biochem. 71 286-301 PubMed GONUTS page

[PMID:17150373-27] Watson, PM et al. (2007) Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Mol. Cell. Neurosci. 34 147-54 PubMed GONUTS page

[PMID:17310240-28] Santos, SD et al. (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9 324-30 PubMed GONUTS page

[PMID:21873635-29] 29.0 ^29.1 ^29.2 ^29.3 ^29.4 ^29.5 ^29.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7768935-30] 30.0 ^30.1 Taylor, GA et al. (1995) Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J. Biol. Chem. 270 13341-7 PubMed GONUTS page

[PMID:19565474-31] 31.00 ^31.01 ^31.02 ^31.03 ^31.04 ^31.05 ^31.06 ^31.07 ^31.08 ^31.09 ^31.10 ^31.11 ^31.12 ^31.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[PMID:11687663-32] Bi, R et al. (2001) Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway. Proc. Natl. Acad. Sci. U.S.A. 98 13391-5 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

[25]

[26]

[27]

[28]

[29]

[30]

[31]

[32]

RAT:MK01

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools