MOUSE:SYUA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Snca (synonyms: Syn)
Protein Name(s)	Alpha-synuclein Non-A beta component of AD amyloid Non-A4 component of amyloid precursor NACP
External Links
UniProt	O55042
EMBL	AF044672 AF033261 AF179273 AF179272 AF179268 AF179269 AF179270 AF179271 AF163865 AK014472 AK156316 BC046764 AF277451
CCDS	CCDS20201.1
RefSeq	NP_001035916.1 NP_033247.1
UniGene	Mm.17484
ProteinModelPortal	O55042
SMR	O55042
BioGrid	203365
IntAct	O55042
MINT	MINT-2736846
PhosphoSite	O55042
MaxQB	O55042
PaxDb	O55042
PRIDE	O55042
Ensembl	ENSMUST00000114268 ENSMUST00000163779
GeneID	20617
KEGG	mmu:20617
UCSC	uc009cdn.1 uc009cdp.1
CTD	6622
MGI	MGI:1277151
eggNOG	NOG44393
GeneTree	ENSGT00390000016161
HOGENOM	HOG000008691
HOVERGEN	HBG000481
InParanoid	O55042
KO	K04528
OMA	PENEAYE
OrthoDB	EOG7034KG
PhylomeDB	O55042
TreeFam	TF332776
Reactome	REACT_198563
NextBio	298995
PMAP-CutDB	O55042
PRO	PR:O55042
Proteomes	UP000000589
Bgee	O55042
CleanEx	MM_SNCA
Genevestigator	O55042
GO	GO:0015629 GO:0005938 GO:0005737 GO:0005856 GO:0005829 GO:0043205 GO:0005794 GO:0030426 GO:0016234 GO:0005739 GO:0005640 GO:0005634 GO:0048471 GO:0005886 GO:0031092 GO:0005840 GO:0005791 GO:0045202 GO:0008021 GO:0043195 GO:0050544 GO:0005509 GO:0005507 GO:0043027 GO:0008198 GO:0042393 GO:0042802 GO:0000287 GO:0016491 GO:0005543 GO:0008270 GO:0006919 GO:0008344 GO:0007568 GO:0048148 GO:0071280 GO:0044344 GO:0034599 GO:0042416 GO:0042417 GO:0006631 GO:0060291 GO:0061024 GO:0001774 GO:0042775 GO:0007006 GO:0045963 GO:0051585 GO:0045920 GO:0035067 GO:0031115 GO:0032769 GO:0043524 GO:0051622 GO:0010642 GO:0001933 GO:0051612 GO:0070495 GO:0032410 GO:0006638 GO:0006644 GO:0045807 GO:0060732 GO:0001956 GO:0033138 GO:0071902 GO:0001921 GO:0051281 GO:0050806 GO:0031648 GO:0031623 GO:0050812 GO:0014059 GO:0060079 GO:0014048 GO:0040012 GO:0048169 GO:0043030 GO:0048168 GO:0046928 GO:0010517 GO:2000377 GO:0042493 GO:0034341 GO:0070555 GO:0010040 GO:0032496 GO:0032026 GO:0050808 GO:0007268 GO:0001963 GO:0048488 GO:0048489
Gene3D	1.10.287.700
InterPro	IPR001058 IPR002460
PANTHER	PTHR13820
Pfam	PF01387
PRINTS	PR01212 PR01211

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001540	beta-amyloid binding	PMID:9453567^[1]	ECO:0000314			F		FIG. 6. Molecular mass determination of A/I-degrading activity from microglia-conditioned medium. Microglia cells were stimulated with LPS.	complete CACAO 5939
part_of	GO:0005886	plasma membrane	PMID:25246573^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	PMID:25246573^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:25246573^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:26203154^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	part_of:(UBERON:0001965) part_of:(CL:2000097) exists_during:(GO:0007569)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	PMID:17222866^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	PMID:25043722^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000232)	Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:21127069^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20457918^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:18980610^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:16959795^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:18980610^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16959795^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:25009269^[10]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:25009269^[10]	ECO:0006062	wide-field fluorescence microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:25009269^[10]	ECO:0006003	electron microscopy evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0048488	synaptic vesicle endocytosis	PMID:25009269^[10]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:28052246^[11]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:28052246^[11]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
part_of	GO:0030672	synaptic vesicle membrane	PMID:28052246^[11]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0000955)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905606	regulation of presynapse assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904715	negative regulation of chaperone-mediated autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903285	positive regulation of hydrogen peroxide catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903284	positive regulation of glutathione peroxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901214	regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
part_of	GO:0099512	supramolecular fiber	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071280	cellular response to copper ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070555	response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061024	membrane organization	PMID:14507911^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060732	positive regulation of inositol phosphate biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:17689254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154692	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:17610578^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429773	P	occurs_in:(EMAPA:32768) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055114	oxidation-reduction process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051622	negative regulation of norepinephrine uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051621	regulation of norepinephrine uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051262	protein tetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050812	regulation of acyl-CoA biosynthetic process	PMID:16636270^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050812	regulation of acyl-CoA biosynthetic process	PMID:16734431^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050808	synapse organization	PMID:20974939^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298397 MGI:MGI:1889011	P	occurs_in:(EMAPA:32770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050806	positive regulation of synaptic transmission	PMID:15579163^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P	regulates_o_has_participant:(EMAPA:32768) regulates_o_has_participant:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
enables	GO:0050544	arachidonic acid binding	PMID:16734431^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048489	synaptic vesicle transport	PMID:12388586^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:32845) occurs_in:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048169	regulation of long-term neuronal synaptic plasticity	PMID:15510220^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429773	P	regulates_o_occurs_in:(EMAPA:32845) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	PMID:17610578^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429773	P	regulates_o_occurs_in:(EMAPA:32768) regulates_o_has_participant:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048148	behavioral response to cocaine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:18333965^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298397	P	regulates_o_occurs_in:(EMAPA:19095)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:15510220^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429773	P	regulates_o_occurs_in:(EMAPA:32845) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:12388586^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	regulates_o_occurs_in:(EMAPA:32768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046928	regulation of neurotransmitter secretion	PMID:10707987^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P	regulates_o_occurs_in:(EMAPA:17549) regulates_o_occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045963	negative regulation of dopamine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045921	positive regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045920	negative regulation of exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045807	positive regulation of endocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:10964942^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:16269331^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:892995	P	regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043030	regulation of macrophage activation	PMID:17035541^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	regulates_o_occurs_in:(EMAPA:16894) regulates_o_occurs_in:(CL:0000129)	Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:10978144^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042775	mitochondrial ATP synthesis coupled electron transport	PMID:16260631^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	PMID:10707987^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042417	dopamine metabolic process	PMID:15465911^[28]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1889011	P	occurs_in:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042416	dopamine biosynthetic process	PMID:10707987^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P	occurs_in:(EMAPA:17549)	Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040012	regulation of locomotion	PMID:10707987^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035493	SNARE complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035067	negative regulation of histone acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	PMID:16298531^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034341	response to interferon-gamma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032769	negative regulation of monooxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032410	negative regulation of transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032026	response to magnesium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031648	protein destabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031623	receptor internalization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
colocalizes_with	GO:0031092	platelet alpha granule membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	PMID:24076025^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016079	synaptic vesicle exocytosis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014059	regulation of dopamine secretion	PMID:18333965^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298397	P	regulates_o_occurs_in:(EMAPA:19095)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014048	regulation of glutamate secretion	PMID:17689254^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154692	P	regulates_o_occurs_in:(EMAPA:32770) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010517	regulation of phospholipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010040	response to iron(II) ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:18333965^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298397	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:20974939^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1298397 MGI:MGI:1889011	P	occurs_in:(EMAPA:32845)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007006	mitochondrial membrane organization	PMID:16260631^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006644	phospholipid metabolic process	PMID:16734431^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006644	phospholipid metabolic process	PMID:16260631^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006644	phospholipid metabolic process	PMID:15938614^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006638	neutral lipid metabolic process	PMID:17250686^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006631	fatty acid metabolic process	PMID:17250686^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006631	fatty acid metabolic process	PMID:14507911^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17475220^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000232)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:17077307^[34]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17549)	Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17475220^[33]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000232)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001963	synaptic transmission, dopaminergic	PMID:12388586^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P	has_participant:(EMAPA:32768)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001963	synaptic transmission, dopaminergic	PMID:10707987^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1888382	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001956	positive regulation of neurotransmitter secretion	PMID:15510220^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32845) regulates_o_occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001921	positive regulation of receptor recycling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	PMID:17035541^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2389489	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P37840	F		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0043027	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043027	P		Seeded From UniProt	complete
involved_in	GO:1905606	regulation of presynapse assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1904715	negative regulation of chaperone-mediated autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1903285	positive regulation of hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1903284	positive regulation of glutathione peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0099512	supramolecular fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0060732	positive regulation of inositol phosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051622	negative regulation of norepinephrine uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051621	regulation of norepinephrine uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051612	negative regulation of serotonin uptake	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0045921	positive regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0045920	negative regulation of exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0045807	positive regulation of endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0035493	SNARE complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0035067	negative regulation of histone acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0034341	response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032769	negative regulation of monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032410	negative regulation of transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0032026	response to magnesium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0031115	negative regulation of microtubule polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0031092	platelet alpha granule membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0019894	kinesin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0016082	synaptic vesicle priming	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
involved_in	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0010517	regulation of phospholipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
involved_in	GO:0010040	response to iron(II) ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0008198	ferrous iron binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:0001921	positive regulation of receptor recycling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
enables	GO:0000149	SNARE binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37840 ensembl:ENSP00000338345	F		Seeded From UniProt	complete
involved_in	GO:1904307	response to desipramine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
involved_in	GO:1901214	regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
involved_in	GO:0048148	behavioral response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
involved_in	GO:0045963	negative regulation of dopamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
part_of	GO:0043679	axon terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0043195	terminal bouton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
involved_in	GO:0042220	response to cocaine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005840	ribosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005791	rough endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005640	nuclear outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P37377 ensembl:ENSRNOP00000030609	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002460	C		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002460	P		Seeded From UniProt	complete
involved_in	GO:0014059	regulation of dopamine secretion	PMID:21563316^[35]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Mentlein, R et al. (1998) Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells. J. Neurochem. 70 721-6 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Burré, J et al. (2014) α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc. Natl. Acad. Sci. U.S.A. 111 E4274-83 PubMed GONUTS page
↑ Tang, FL et al. (2015) VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. J. Neurosci. 35 10613-28 PubMed GONUTS page
↑ Volles, MJ & Lansbury, PT Jr (2007) Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. J. Mol. Biol. 366 1510-22 PubMed GONUTS page
↑ Renella, R et al. (2014) Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. Am. J. Hematol. 89 974-7 PubMed GONUTS page
↑ Qureshi, HY & Paudel, HK (2011) Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J. Biol. Chem. 286 5055-68 PubMed GONUTS page
↑ Tong, Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. U.S.A. 107 9879-84 PubMed GONUTS page
↑ ^8.0 ^8.1 Ben Gedalya, T et al. (2009) Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 10 218-34 PubMed GONUTS page
↑ ^9.0 ^9.1 Kontopoulos, E et al. (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet. 15 3012-23 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Vargas, KJ et al. (2014) Synucleins regulate the kinetics of synaptic vesicle endocytosis. J. Neurosci. 34 9364-76 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Vargas, KJ et al. (2017) Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep 18 161-173 PubMed GONUTS page
↑ ^12.0 ^12.1 Sharon, R et al. (2003) Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J. Biol. Chem. 278 49874-81 PubMed GONUTS page
↑ ^13.0 ^13.1 Gureviciene, I et al. (2007) Role of alpha-synuclein in synaptic glutamate release. Neurobiol. Dis. 28 83-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Liu, S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25 3583-96 PubMed GONUTS page
↑ Stanic, AK et al. (2006) Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc. Natl. Acad. Sci. U.S.A. 103 7018-23 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Golovko, MY et al. (2006) Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. Biochemistry 45 6956-66 PubMed GONUTS page
↑ ^17.0 ^17.1 Greten-Harrison, B et al. (2010) αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc. Natl. Acad. Sci. U.S.A. 107 19573-8 PubMed GONUTS page
↑ Martín, ED et al. (2004) Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. Eur. J. Neurosci. 20 3085-91 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Cabin, DE et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22 8797-807 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Liu, S et al. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J. 23 4506-16 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Senior, SL et al. (2008) Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur. J. Neurosci. 27 947-57 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Abeliovich, A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 239-52 PubMed GONUTS page
↑ Kahle, PJ et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J. Neurosci. 20 6365-73 PubMed GONUTS page
↑ Chandra, S et al. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123 383-96 PubMed GONUTS page
↑ ^25.0 ^25.1 Austin, SA et al. (2006) Alpha-synuclein expression modulates microglial activation phenotype. J. Neurosci. 26 10558-63 PubMed GONUTS page
↑ Rochet, JC et al. (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39 10619-26 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Ellis, CE et al. (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol. Cell. Biol. 25 10190-201 PubMed GONUTS page
↑ Chandra, S et al. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc. Natl. Acad. Sci. U.S.A. 101 14966-71 PubMed GONUTS page
↑ Klivenyi, P et al. (2006) Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol. Dis. 21 541-8 PubMed GONUTS page
↑ Roy, A & Pahan, K (2013) Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease. FEBS Lett. 587 3567-74 PubMed GONUTS page
↑ Golovko, MY et al. (2005) Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding. Biochemistry 44 8251-9 PubMed GONUTS page
↑ ^32.0 ^32.1 Barceló-Coblijn, G et al. (2007) Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice. J. Neurochem. 101 132-41 PubMed GONUTS page
↑ ^33.0 ^33.1 Nakai, M et al. (2007) Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem. Biophys. Res. Commun. 358 104-10 PubMed GONUTS page
↑ Duka, T et al. (2006) Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J. 20 2302-12 PubMed GONUTS page
↑ Esposito, G et al. (2012) Synaptic vesicle trafficking and Parkinson's disease. Dev Neurobiol 72 134-44 PubMed GONUTS page

[PMID:9453567-1] Mentlein, R et al. (1998) Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells. J. Neurochem. 70 721-6 PubMed GONUTS page

[PMID:25246573-2] 2.0 ^2.1 ^2.2 Burré, J et al. (2014) α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proc. Natl. Acad. Sci. U.S.A. 111 E4274-83 PubMed GONUTS page

[PMID:26203154-3] Tang, FL et al. (2015) VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. J. Neurosci. 35 10613-28 PubMed GONUTS page

[PMID:17222866-4] Volles, MJ & Lansbury, PT Jr (2007) Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. J. Mol. Biol. 366 1510-22 PubMed GONUTS page

[PMID:25043722-5] Renella, R et al. (2014) Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. Am. J. Hematol. 89 974-7 PubMed GONUTS page

[PMID:21127069-6] Qureshi, HY & Paudel, HK (2011) Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J. Biol. Chem. 286 5055-68 PubMed GONUTS page

[PMID:20457918-7] Tong, Y et al. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. U.S.A. 107 9879-84 PubMed GONUTS page

[PMID:18980610-8] 8.0 ^8.1 Ben Gedalya, T et al. (2009) Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic 10 218-34 PubMed GONUTS page

[PMID:16959795-9] 9.0 ^9.1 Kontopoulos, E et al. (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet. 15 3012-23 PubMed GONUTS page

[PMID:25009269-10] 10.0 ^10.1 ^10.2 ^10.3 Vargas, KJ et al. (2014) Synucleins regulate the kinetics of synaptic vesicle endocytosis. J. Neurosci. 34 9364-76 PubMed GONUTS page

[PMID:28052246-11] 11.0 ^11.1 ^11.2 Vargas, KJ et al. (2017) Synucleins Have Multiple Effects on Presynaptic Architecture. Cell Rep 18 161-173 PubMed GONUTS page

[PMID:14507911-12] 12.0 ^12.1 Sharon, R et al. (2003) Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. J. Biol. Chem. 278 49874-81 PubMed GONUTS page

[PMID:17689254-13] 13.0 ^13.1 Gureviciene, I et al. (2007) Role of alpha-synuclein in synaptic glutamate release. Neurobiol. Dis. 28 83-9 PubMed GONUTS page

[PMID:17610578-14] 14.0 ^14.1 Liu, S et al. (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25 3583-96 PubMed GONUTS page

[PMID:16636270-15] Stanic, AK et al. (2006) Immune dysregulation accelerates atherosclerosis and modulates plaque composition in systemic lupus erythematosus. Proc. Natl. Acad. Sci. U.S.A. 103 7018-23 PubMed GONUTS page

[PMID:16734431-16] 16.0 ^16.1 ^16.2 Golovko, MY et al. (2006) Acyl-CoA synthetase activity links wild-type but not mutant alpha-synuclein to brain arachidonate metabolism. Biochemistry 45 6956-66 PubMed GONUTS page

[PMID:20974939-17] 17.0 ^17.1 Greten-Harrison, B et al. (2010) αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc. Natl. Acad. Sci. U.S.A. 107 19573-8 PubMed GONUTS page

[PMID:15579163-18] Martín, ED et al. (2004) Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice. Eur. J. Neurosci. 20 3085-91 PubMed GONUTS page

[PMID:12388586-19] 19.0 ^19.1 ^19.2 Cabin, DE et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J. Neurosci. 22 8797-807 PubMed GONUTS page

[PMID:15510220-20] 20.0 ^20.1 ^20.2 Liu, S et al. (2004) alpha-Synuclein produces a long-lasting increase in neurotransmitter release. EMBO J. 23 4506-16 PubMed GONUTS page

[PMID:18333965-21] 21.0 ^21.1 ^21.2 Senior, SL et al. (2008) Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein. Eur. J. Neurosci. 27 947-57 PubMed GONUTS page

[PMID:10707987-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Abeliovich, A et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25 239-52 PubMed GONUTS page

[PMID:10964942-23] Kahle, PJ et al. (2000) Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J. Neurosci. 20 6365-73 PubMed GONUTS page

[PMID:16269331-24] Chandra, S et al. (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123 383-96 PubMed GONUTS page

[PMID:17035541-25] 25.0 ^25.1 Austin, SA et al. (2006) Alpha-synuclein expression modulates microglial activation phenotype. J. Neurosci. 26 10558-63 PubMed GONUTS page

[PMID:10978144-26] Rochet, JC et al. (2000) Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein. Biochemistry 39 10619-26 PubMed GONUTS page

[PMID:16260631-27] 27.0 ^27.1 ^27.2 Ellis, CE et al. (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol. Cell. Biol. 25 10190-201 PubMed GONUTS page

[PMID:15465911-28] Chandra, S et al. (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc. Natl. Acad. Sci. U.S.A. 101 14966-71 PubMed GONUTS page

[PMID:16298531-29] Klivenyi, P et al. (2006) Mice lacking alpha-synuclein are resistant to mitochondrial toxins. Neurobiol. Dis. 21 541-8 PubMed GONUTS page

[PMID:24076025-30] Roy, A & Pahan, K (2013) Ankyrin repeat and BTB/POZ domain containing protein-2 inhibits the aggregation of alpha-synuclein: implications for Parkinson's disease. FEBS Lett. 587 3567-74 PubMed GONUTS page

[PMID:15938614-31] Golovko, MY et al. (2005) Alpha-synuclein gene deletion decreases brain palmitate uptake and alters the palmitate metabolism in the absence of alpha-synuclein palmitate binding. Biochemistry 44 8251-9 PubMed GONUTS page

[PMID:17250686-32] 32.0 ^32.1 Barceló-Coblijn, G et al. (2007) Brain neutral lipids mass is increased in alpha-synuclein gene-ablated mice. J. Neurochem. 101 132-41 PubMed GONUTS page

[PMID:17475220-33] 33.0 ^33.1 Nakai, M et al. (2007) Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage. Biochem. Biophys. Res. Commun. 358 104-10 PubMed GONUTS page

[PMID:17077307-34] Duka, T et al. (2006) Alpha-synuclein induces hyperphosphorylation of Tau in the MPTP model of parkinsonism. FASEB J. 20 2302-12 PubMed GONUTS page

[PMID:21563316-35] Esposito, G et al. (2012) Synaptic vesicle trafficking and Parkinson's disease. Dev Neurobiol 72 134-44 PubMed GONUTS page

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