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PMID:17610578
| Citation |
Liu, S, Fa, M, Ninan, I, Trinchese, F, Dauer, W and Arancio, O (2007) Alpha-synuclein involvement in hippocampal synaptic plasticity: role of NO, cGMP, cGK and CaMKII. Eur. J. Neurosci. 25:3583-96 |
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| Abstract |
Synaptic plasticity involves a series of coordinate changes occurring both pre- and postsynaptically, of which alpha-synuclein is an integral part. We have investigated on mouse primary hippocampal neurons in culture whether redistribution of alpha-synuclein during plasticity involves retrograde signaling activation through nitric oxide (NO), cGMP, cGMP-dependent protein kinase (cGK) and calmodulin-dependent protein kinase II. We have found that deletion of the alpha-synuclein gene blocks both the long-lasting enhancement of evoked and miniature transmitter release and the increase in the number of functional presynaptic boutons evoked through the NO donor, DEA/NO, and the cGMP analog, 8-Br-cGMP. In agreement with these findings both DEA/NO and 8-Br-cGMP were capable of producing a long-lasting increase in number of clusters for alpha-synuclein through activation of soluble guanylyl cyclase, cGK and calcium/calmodulin-dependent protein kinase IIalpha. Thus, our results suggest that NO, cGMP, GMP-dependent protein kinase and calmodulin-dependent protein kinase II play a key role in the redistribution of alpha-synuclein during plasticity. |
| Links |
PubMed Online version:10.1111/j.1460-9568.2007.05569.x |
| Keywords |
Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases/physiology; Cell Count; Cells, Cultured; Cyclic GMP/physiology; Cyclic GMP-Dependent Protein Kinases/physiology; Drug Interactions; Enzyme Inhibitors/pharmacology; Glutamic Acid/pharmacology; Hippocampus/cytology; Mice; Mice, Knockout; Neuronal Plasticity/drug effects; Neuronal Plasticity/physiology; Neurons/drug effects; Neurons/physiology; Nitric Oxide/physiology; Patch-Clamp Techniques/methods; Synapses/drug effects; Synapses/physiology; alpha-Synuclein/deficiency; alpha-Synuclein/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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